Even with its international flair and reputation as an iconic center for progressive art and design, Basel’s medieval town center invites exploration by foot with an abundance of museums and galleries. While antiquity may be Basel’s strong suit, two of its native sons – architects Herzog & de Meuron renowned design London’s Tate Modern Beijing’s Bird’s Nest – bring a modern flair to the city’s design along with other notable architects including Frank Gehry.

The seat of the European Parliament, Strasbourg is one of the world’s most photogenic towns. It boasts a breathtaking Gothic cathedral and a remarkable charm that oozes from virtually every cozy corner of Grande Île, or “Large Island,” the first city center to be named a UNESCO World Heritage Site.

Nestled on the Rhine River between Karlsruhe and Speyer, in the German state of Rhineland-Palatinate, the quaint town of Germersheim is best known for its iconic Weissenburg Gate, part of a 19th-century fortress built to protect the left bank of the Rhine against France. The town's verdant parks, cobbled lanes, lovely squares and historical buildings, such as the 18th-century City Hall and centuries-old St. Jakobus Church, are complemented by a wide variety of restaurants, cafés and bars.

The name Benz is synonymous with automotive innovation, and here is where this legacy began. Also born here was the “man-powered running machine” (or bicycle), the Lanz Bulldog tractor and first rocket-powered aircraft, firmly establishing the city as the place for innovation and industry. The university town is also alive with hubs of diverse food, drink and shopping, as well as a thriving art and musical culture.

If Rüdesheim’s scenic location on the UNESCO-designated Rhine Gorge doesn’t sweep you off your feet, then the town’s medieval Old Town with its half-timbered buildings and narrow lanes, especially the Drosselgasse overflowing with charming shops and taverns, surely will. The region’s renowned Rieslings, produced here for centuries from vineyards dating to Roman times, promise to delight, too.

Spend the remainder of the afternoon cruising the romantic Rhine toward Koblenz.

Located where the Rhine and Moselle rivers and three mountain ranges meet, Koblenz’ scenery is unmatched. Add to that the city’s 2,000-year-old history, hilltop fortress and squares lined by classic Germanic architecture and you have a place ready-made for photos. Ambling along the town’s narrow lanes and river promenade, you might encounter medieval churches, flower-filled parks, sidewalk cafes and perhaps a weinstube, or wine tavern, ideal for sipping Riesling and drinking in the atmosphere.

Germany’s most visited landmark – the UNESCO-listed Cologne Cathedral – dominates the skyline here, its magnificent Gothic twin-spires reaching toward the heavens. Peel your eyes away from the Kölner Dom, its local name, to see the space needle-like Rhine Tower, ancient Roman ruins, a modern museum, cozy beerhalls and the arches of the Hohenzollern Bridge, reconstructed after the war.

Everyone has an image of Amsterdam. For some, it’s small boats gliding on the canals and locals two-wheeling on bikes to work and, as frequently, to meet friends for drinks. For others, it’s gabled buildings leaning, seemingly precariously, over cobbled streets and cozy taverns illuminated by candles. Still, others imagine tulips in bloom and the paintings Vermeer, Van Gogh and Rembrandt. Each vision is even more beguiling when experienced in person.

Disembark the ship this morning after breakfast.