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Top Mississippi River Trips & Tours in October 2022

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New Orleans
Sean Pavone
Visit the famed Bourbon Street
St Louis
Sean Pavone
View the iconic arch when you visit St. Louis, gateway to the west
Vicksburg
Michael Warren
View a Civil War battlefields in Mississippi
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Discover Mississippi River in October 2022 on one of these 9 tours hand-selected by the travel experts at Adventure Life. Explore the best of Memphis, St. Louis, New Orleans, Natchez, and Vicksburg during October 2022 as you enjoy village visits, archaeological site visits, and urban exploration. Prices for trips in October 2022 range from $1,999 to $28,499 for a vacation of 8 to 15 days. Choose any of the below 9 amazing itineraries in October 2022 and customize it to make it your own with the help of one of Adventure Life's expert Mississippi River trip planners.
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Visit historic St. Louis
$2,699
EXPLORE

Memphis to St. Louis

9 Day Itinerary aboard American Queen
  • Listen to the music of Memphis
  • Explore wonders of New Madrid
  • Admire historic handicrafts
  • Explore the culture of St. Louis
Starts/ Ends in:
Memphis / St. Louis
Activities:
River Cruises, Village Visits
Activity Level:
Relaxed
Board the American Queen and join this delightful 9-day journey From the legacies that line the Mississippi River to the corners of creative genius along Ohio, your riverboat journey promises a wealth of eye-opening experiences and memories. Explore the seismic wonders of New Madrid and the iconic …
Cruise Details
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View the iconic arch when you visit St. Louis, gateway to the west
$21,599
EXPLORE

America’s Great River

St. Paul to New Orleans - 15 Day Itinerary aboard Viking Mississippi
  • Explore St. Louis' arts scene
  • Enjoy American music styles
  • Learn Civil War history
  • Experience New Orleans' culture
  • Visit the Quad Cities
Starts/ Ends in:
St. Paul / New Orleans
Activities:
Archaeological Sites, River Cruise, Village Visit
Activity Level:
Relaxed
Discover the history, natural beauty, and distinctive regional cultures of America's great river, the mighty Mississippi, on this 15-day cruise aboard Viking Mississippi. Set sail from St. Paul, Minnesota, and venture south toward New Orleans, Louisiana. Along the way, visit small towns and …
Cruise Details
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Visit historic Memphis, Tennessee
$5,499
EXPLORE

Heart of the Delta

New Orleans to Memphis - 8 Day Itinerary aboard Viking Mississippi
  • Enjoy the music of Memphis
  • Get a taste of Cajun cuisine
  • Discover Civil War history
  • See the historic homes of Natchez
Starts/ Ends in:
New Orleans / Memphis
Activities:
Archaeological Sites, River Cruise, Urban Exploration, Village Visit
Activity Level:
Relaxed
Immerse yourself in the history and heritage of the Mississippi River on this 8-day voyage from New Orleans to Memphis. Soak up the rich French and Acadian cultures that infuse the Lower Mississippi, and be inspired by the stories of famed musicians and Civil Rights heroes. Savor delicious Cajun …
Cruise Details
0
$2,899
EXPLORE

New Orleans to Memphis

9 Day Itinerary aboard American Duchess
  • Discover St. Francisville
  • Experience the music of Memphis
  • Learn the history of Vicksburg
  • Explore vibrant New Orleans
Starts/ Ends in:
New Orleans / Memphis
Activities:
Archaeological Site Visits, River Cruises
Activity Level:
Relaxed
The Lower Mississippi River has stories to share – a legacy that flows from Memphis to the Gulf of Mexico. Embark on more than just a cruise, and return with more than memories: experience, understanding, an enlightened perspective. Explore the American South and discover all the great sights …
Cruise Details
0
$2,499
EXPLORE

New Orleans to Memphis

9 Day Itinerary aboard American Countess
  • Discover St. Francisville
  • Experience the music of Memphis
  • Learn the history of Vicksburg
  • Explore vibrant New Orleans
Starts/ Ends in:
New Orleans / Memphis
Activities:
Archaeological Site Visits, River Cruises
Activity Level:
Relaxed
The Lower Mississippi River has stories to share – a legacy that flows from Memphis to the Gulf of Mexico. Embark on more than just a cruise, and return with more than memories: experience, understanding, an enlightened perspective. Explore the American South and discover all the great sights …
Cruise Details
0
$2,499
EXPLORE

Memphis to Louisville

9 Day Itinerary aboard American Duchess
  • Taste authentic local bourbon
  • Enjoy small-town hospitality
  • Listen to the music of Memphis
  • Explore artsy Louisville
Starts/ Ends in:
Memphis / Louisville
Activities:
River Cruises, Village Visits
Activity Level:
Relaxed
Board the American Duchess and join this delightful 9-day journey from Memphis, Tennessee to Louisville, Kentucky. Cruise the Mississippi and Ohio rivers and explore the cultural highlights of this region, from the musical traditions of Memphis and Owensboro to the artistic communities of Henderson …
Cruise Details
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St. Louis' iconic arch at night
$2,699
EXPLORE

St. Louis to Minneapolis

9 Day Itinerary aboard American Queen
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Relax in laid-back La Crosse
  • Admire local artwork in Red Wing
Starts/ Ends in:
St. Louis / Red Wing
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Explore the land and river that inspired legendary American author Samuel Clemens, better known by his pen name, Mark Twain. Cruise northward from St. Louis, Missouri along the mighty Mississippi River, toward the city of Minneapolis. Along the way, explore port towns such as Hannibal, Missouri, …
Cruise Details
0
$2,699
EXPLORE

Minneapolis to St. Louis

9 Day Itinerary aboard American Queen
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Relax in laid-back La Crosse
  • Admire local artwork in Red Wing
Starts/ Ends in:
St. Louis / Red Wing
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Discover the region and river that inspired famed American novelist Samuel Clemens, better known as Mark Twain. On this 9-day cruise onboard American Queen, sail north from St. Louis, Missouri, along the magnificent Mississippi River toward the city of Minneapolis. Along the way, visit port towns …
Cruise Details
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Explore beautiful Nashville
$2,699
EXPLORE

St. Louis to Nashville

9 Day Itinerary aboard American Queen
  • Explore Nashville, Tennessee
  • Visit the National Quilt Museum
  • Experience small-town charm
  • Stop at the Popeye Character Trail
  • Enjoy the museums of St. Louis
Starts/ Ends in:
Nashville / Alton
Activities:
River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Immerse yourself in the history, music, and culture of this distinctive region on this enchanting 9-day journey on the Cumberland and Mississippi rivers. Set off from St. Louis, Missouri, the "Gateway to the West" and home to a colorful history and a vibrant arts scene.Learn about the …
Cruise Details
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