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Top Mississippi River Trips & Tours in September 2022

Travel made your way
New Orleans
Sean Pavone
Visit the famed Bourbon Street
St Louis
Sean Pavone
View the iconic arch when you visit St. Louis, gateway to the west
Vicksburg
Michael Warren
View a Civil War battlefields in Mississippi
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Discover Mississippi River in September 2022 on one of these 10 tours hand-selected by the travel experts at Adventure Life. Explore the best of St. Louis, La Crosse, Red Wing, Dubuque, and Hannibal during September 2022 as you enjoy village visits, archaeological site visits, and urban exploration. Prices for trips in September 2022 range from $1,999 to $103,999 for a vacation of 9 to 16 days. Choose any of the below 10 amazing itineraries in September 2022 and customize it to make it your own with the help of one of Adventure Life's expert Mississippi River trip planners.
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    • Mississippi River
Explore the rivers of America
$2,899
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EXPLORE

St. Louis to Minneapolis

9 Day Itinerary aboard American Duchess
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Relax in laid-back La Crosse
  • Admire local artwork in Red Wing
Starts/ Ends in:
St. Louis / Red Wing
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Explore the land and river that inspired legendary American author Samuel Clemens, better known by his pen name, Mark Twain. Cruise northward from St. Louis, Missouri along the mighty Mississippi River, toward the city of Minneapolis. Along the way, explore port towns such as Hannibal, Missouri, …
Cruise Details
0
New Orleans paddlewheel steamer in New Orleans, Lousiana
$2,699
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EXPLORE

New Orleans to Memphis

9 Day Itinerary aboard American Queen
  • Explore vibrant New Orleans
  • Experience the music of Memphis
  • Learn the history of Vicksburg
  • Explore Nottoway Plantation
Starts/ Ends in:
New Orleans / Memphis
Activities:
Archaeological Site Visits, River Cruises
Activity Level:
Relaxed
The Lower Mississippi River has stories to share – a legacy that flows from Memphis to the Gulf of Mexico. Embark on more than just a cruise, and return with more than memories: experience, understanding, an enlightened perspective. Explore the American South and discover all the great sights …
Cruise Details
0
View monuments from the Civil War in Mississippi
$5,499
EXPLORE

Minneapolis to New Orleans

16 Day Itinerary aboard American Duchess
  • Enjoy musical history in Memphis
  • Explore the arts in Minneapolis, MN
  • Discover St. Louis, Missouri
  • Admire the diversity of New Orleans
  • Learn about Civil War history
Starts/ Ends in:
Minneapolis / New Orleans
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Watch landscapes, cultures and even language transform as you cruise along the Mississippi river from Minneapolis to New Orleans aboard the American Duchess. Board this 16-day cruise to sail nearly the full length of the mighty Mississippi. Along the way, visit historic port cities and laid-back …
Cruise Details
0
Visit historic St. Louis
$2,499
Save 50%
EXPLORE

St. Louis to Minneapolis

9 Day Itinerary aboard American Countess
  • Explore the culture of St. Louis
  • See Mark Twains hometown, Hannibal
  • Relax in laid-back La Crosse
  • Admire local artwork in Red Wing
Starts/ Ends in:
St. Louis / Red Wing
Activities:
Archaeological Site Visits, River Cruises, Village Visits
Activity Level:
Relaxed
Explore the country and river that inspired Mark Twain, the pen name of the famed American novelist Samuel Clemens. From St. Louis, Missouri, cruise north along the magnificent Mississippi River towards Minneapolis. Explore port towns such as Hannibal, Missouri, the birthplace of Mark Twain, and …
Cruise Details
0
$2,499
Save 50%
EXPLORE

Louisville to St. Louis

9 Day Itinerary aboard American Countess
  • Taste famous Kentucky bourbon
  • Enjoy the music of Owensboro
  • Admire historic handicrafts
  • Explore vibrant St. Louis
Starts/ Ends in:
Louisville / St. Louis
Activities:
River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Board the American Countess riverboat and cruise through the heart of the American Midwest on this 9-day journey from Louisville, Kentucky to St. Louis, Missouri on the Ohio and Mississippi Rivers. Experience the laid-back, small-town hospitality of Kentucky ports such as Owensboro, where …
Cruise Details
0
Explore historic New Orleans
$5,099
EXPLORE

Minneapolis to New Orleans

16 Day Itinerary aboard American Queen
  • Enjoy musical history in Memphis
  • Admire the diversity of New Orleans
  • Discover St. Louis, Missouri
  • Explore the arts in Minneapolis, MN
  • Learn about Civil War history
Starts/ Ends in:
Minneapolis / New Orleans
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Watch landscapes, cultures and even language transform as you cruise along the Mississippi river from Minneapolis to New Orleans aboard the American Queen. Board this 16-day cruise to sail nearly the full length of the mighty Mississippi. Along the way, visit historic port cities and laid-back …
Cruise Details
0
View the iconic arch when you visit St. Louis, gateway to the west
$4,999
EXPLORE

Minneapolis to New Orleans

16 Day Itinerary aboard American Countess
  • Explore the arts in Minneapolis, MN
  • Discover St. Louis, Missouri
  • Enjoy musical history in Memphis
  • Learn about Civil War history
  • Admire the diversity of New Orleans
Starts/ Ends in:
Minneapolis / New Orleans
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
As you sail the Mississippi River from Minneapolis to New Orleans aboard the American Countess, observe how landscapes, cultures, and even language change. Sail nearly the whole length of the mighty Mississippi on this 16-day voyage. Visit ancient port cities and sleepy small towns along the way to …
Cruise Details
0
St. Louis' iconic arch at night
$2,699
Save 50%
EXPLORE

St. Louis to Minneapolis

9 Day Itinerary aboard American Queen
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Relax in laid-back La Crosse
  • Admire local artwork in Red Wing
Starts/ Ends in:
St. Louis / Red Wing
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Explore the land and river that inspired legendary American author Samuel Clemens, better known by his pen name, Mark Twain. Cruise northward from St. Louis, Missouri along the mighty Mississippi River, toward the city of Minneapolis. Along the way, explore port towns such as Hannibal, Missouri, …
Cruise Details
0
Visit historic St. Louis
$2,899
EXPLORE

Minneapolis to St. Louis

9 Day Itinerary aboard American Duchess
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Relax in laid-back La Crosse
  • Admire local artwork in Red Wing
Starts/ Ends in:
St. Louis / Red Wing
Activities:
Archaeological Site Visits, River Cruises, Village Visits
Activity Level:
Relaxed
Discover the region and river that inspired renowned American novelist Samuel Clemens, better known as Mark Twain. Sail north from Minneapolis on this 9-day voyage aboard American Countess along the gorgeous Mississippi River toward the city of St. Louis. Along the way, stop in port towns such as …
Cruise Details
0
$2,399
EXPLORE

American Culinary Experience

Louisville to St. Louis - 9 Day Itinerary aboard American Countess
  • Explore vibrant St. Louis
  • Admire historic handicrafts
  • Enjoy the music of Owensboro
  • Taste famous Kentucky bourbon
Starts/ Ends in:
Louisville / St. Louis
Activities:
River Cruises, Village Visits
Activity Level:
Relaxed
On this 9-day voyage from Louisville, Kentucky to St. Louis, Missouri through the Ohio and Mississippi rivers, board the American Countess riverboat and travel through the heart of the American Midwest. Experience the laid-back, small-town hospitality of Kentucky ports such as Owensboro, where …
Cruise Details
0
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