Have questions? We're here.
Maysville, Kentucky

Top Cape Girardeau Trips & Tours in 2022

Travel made your way
Talk with an expert
Build your ideal Mississippi River trip. Call 1.406.541.2677
Start Planning My Trip
Discover Cape Girardeau in 2022 on one of these amazing trips hand selected by the travel experts at Adventure Life. Select any of the below 11 top-rated trips where you will explore Cape Girardeau with an exceptional bilingual guide on a small group or customizable private tour. The most popular things to do in Cape Girardeau in 2022 are river cruises, cruises, cultural, village visits, and classic. Our Cape Girardeau trips in 2022 range in price from $1,999 to $10,199 for trips of 9 to 13 days. Contact one of Adventure Life's expert Cape Girardeau trip planners for help planning a seamless experience.
Filter (11 Results)
  • Start Date
    OR, More specific start
  • Length
    to
  • Price
    to
  • Activity Level
  • Experiences
  • Activities
  • Ship
  • Destinations
    • Cape Girardeau
Visit historic St. Louis
$2,699
EXPLORE

Memphis to St. Louis

9 Day Itinerary aboard American Queen
  • Listen to the music of Memphis
  • Explore wonders of New Madrid
  • Admire historic handicrafts
  • Explore the culture of St. Louis
Starts / Ends:
Memphis / St. Louis
Activities:
River Cruises, Village Visits
Activity Level:
Relaxed
Board the American Queen and join this delightful 9-day journey From the legacies that line the Mississippi River to the corners of creative genius along Ohio, your riverboat journey promises a wealth of eye-opening experiences and memories. Explore the seismic wonders of New Madrid and the iconic …
Cruise Details
0
$2,299
EXPLORE

Louisville to St. Louis

9 Day Itinerary aboard American Countess
  • Taste famous Kentucky bourbon
  • Enjoy the music of Owensboro
  • Admire historic handicrafts
  • Explore vibrant St. Louis
Starts / Ends:
Louisville / St. Louis
Activities:
River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Board the American Countess riverboat and cruise through the heart of the American Midwest on this 9-day journey from Louisville, Kentucky to St. Louis, Missouri on the Ohio and Mississippi Rivers. Experience the laid-back, small-town hospitality of Kentucky ports such as Owensboro, where …
Cruise Details
0
Explore beautiful Nashville
$1,999
EXPLORE

Nashville to Memphis

9 Day Itinerary aboard American Queen
  • Explore Nashville, Tennessee
  • Learn Civil War history
  • Visit the National Quilt Museum
  • Enjoy the music and food of Memphis
Starts / Ends:
Nashville / Memphis
Activities:
Archaeological Site Visits, River Cruises
Activity Level:
Relaxed
Immerse yourself in the history, music, and culture of this distinctive region on this enchanting 9-day journey on the Cumberland and Mississippi rivers. Set sail from Nashville, considered by many to be the capital of country music. Experience laid-back, small-town charm in Dover, Tennessee, and …
Cruise Details
0
Explore beautiful Nashville
$2,599
EXPLORE

St. Louis to Nashville

9 Day Itinerary aboard American Queen
  • Explore Nashville, Tennessee
  • Visit the National Quilt Museum
  • Experience small-town charm
  • Stop at the Popeye Character Trail
  • Enjoy the museums of St. Louis
Starts / Ends:
Nashville / Alton
Activities:
River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Immerse yourself in the history, music, and culture of this distinctive region on this enchanting 9-day journey on the Cumberland and Mississippi rivers. Set off from St. Louis, Missouri, the "Gateway to the West" and home to a colorful history and a vibrant arts scene.Learn about the …
Cruise Details
0
Explore beautiful Nashville
$2,699
Savings
EXPLORE

Memphis to Nashville

9 Day Itinerary aboard American Queen
  • Explore Nashville, Tennessee
  • Experience small-town charm
  • Visit the National Quilt Museum
  • Enjoy the music and food of Memphis
Starts / Ends:
Memphis / Clarksville
Activities:
River Cruises
Activity Level:
Relaxed
Discover the history, music, and culture of this distinct region on this 9-day adventure along the Cumberland and Mississippi rivers. As you begin your adventure in the Home of the Blues, the planet erupts in a profusion of greens. Observe the transformation's splendor while standing on the …
Cruise Details
0
Explore beautiful Nashville
$2,799
EXPLORE

Nashville to St. Louis

9 Day Itinerary aboard American Duchess
  • Explore Nashville, Tennessee
  • Visit the National Quilt Museum
  • Experience small-town charm
  • Stop at the Popeye Character Trail
  • Enjoy the museums of St. Louis
Starts / Ends:
Nashville / Alton
Activities:
River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Spend time learning about North America's rich heritage through its music and arton this enchanting 9-day journey on the Cumberland and Mississippi rivers. Set off from Nashville, considered by many to be the capital of country music. Experience laid-back, small-town charm in Dover, Tennessee, …
Cruise Details
0
Enjoy vibrant nightlife and live music
$2,299
EXPLORE

Memphis to St. Louis

(or reverse) - 9 Day Itinerary aboard American Duchess
  • Explore Memphis
  • Discover New Madrid
  • Experience Paducah's history
  • Visit Cape Girardeau
Starts / Ends:
Memphis / St. Louis
Activities:
River Cruises, Small Ship Cruises, Urban Exploration
Activity Level:
Relaxed
From Memphis to St. Louis, the Lower Mississippi River is loaded with stories to tell. From the legacies that line the Mississippi to the imaginative corners of Ohio, this 9-day riverboat tour promises a variety of enlightening encounters and unforgettable memories. Explore the seismic wonders of …
Cruise Details
0
$2,499
EXPLORE

American Culinary Experience

9 Day Itinerary aboard American Duchess
  • Explore vibrant St. Louis
  • Admire historic handicrafts
  • Enjoy the music of Owensboro
  • Taste famous Kentucky bourbon
Starts / Ends:
Louisville / St. Louis
Activities:
River Cruises, Village Visits
Activity Level:
Relaxed
Board the American Duchess riverboat and sail through the heart of the American Midwest on this 9-day adventure along the Ohio and Mississippi rivers from Louisville, Kentucky to St. Louis, Missouri. Discover the laid-back, small-town friendliness of Kentucky ports such as Owensboro, where …
Cruise Details
0
Visit historic Memphis, Tennessee
$3,899
EXPLORE

Memphis to Chattanooga

13 Day Itinerary aboard American Countess
  • Discover the music of Memphis
  • Learn local history in New Madrid
  • Admire handicrafts in Paducah
  • Tour adventure-rich Chattanooga
Starts / Ends:
Memphis / Chattanooga
Activities:
Urban Exploration, Village Visits
Activity Level:
Relaxed
On this 13-day voyage along the Mississippi and Tennessee rivers, reminisce and learn about American history. Learn why so many have fallen in love with the river's soothing character by exploring its hidden havens. Memphis is the origin of well-known American musical genres such as the blues …
Cruise Details
0
Explore beautiful Nashville
$2,499
EXPLORE

Nashville to St. Louis

9 Day Itinerary aboard American Countess
  • Explore Nashville, Tennessee
  • Visit the National Quilt Museum
  • Experience small-town charm
  • Stop at the Popeye Character Trail
  • Enjoy the museums of St. Louis
Starts / Ends:
Nashville / Alton
Activities:
River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Set sail on a 9-day river cruise along the Cumberland and Mississippi rivers to learn about the region's history, music, and culture. Set out from Nashville, which is widely regarded as the country music capital of the world. The small hamlet of Dover, Tennessee, is a fascinating place to visit …
Cruise Details
0
$2,299
EXPLORE

American Culinary Experience

Louisville to St. Louis - 9 Day Itinerary aboard American Countess
  • Explore vibrant St. Louis
  • Admire historic handicrafts
  • Enjoy the music of Owensboro
  • Taste famous Kentucky bourbon
Starts / Ends:
Louisville / St. Louis
Activities:
River Cruises, Village Visits
Activity Level:
Relaxed
On this 9-day voyage from Louisville, Kentucky to St. Louis, Missouri through the Ohio and Mississippi rivers, board the American Countess riverboat and travel through the heart of the American Midwest. Experience the laid-back, small-town hospitality of Kentucky ports such as Owensboro, where …
Cruise Details
0
1-11 of 11 Results

Top Cape Girardeau Travel Destinations

Cape Girardeau Trips by Departure Date

Top Experiences in Cape Girardeau

Cape Girardeau Trips by Activity

More Reasons

Why Travel With Adventure Life

All News

Recognized By