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Top Mannheim Trips & Tours in September 2026

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Discover Mannheim in September 2026 on one of these 22 tours hand-selected by the travel experts at Adventure Life. Explore the best of during September 2026 as you enjoy Wine Tasting, Hiking, Village Visits, Biking, and Archaeological Site Visits. Prices for trips in September 2026 range from $930 to $20,790 for a vacation of 5 to 15 days. Choose any of the below 22 itineraries in September 2026 and customize it when you contact one of Adventure Life's expert Mannheim trip planners.
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View of Strasbourg city
from $4,849
EXPLORE

Enchanting Rhine - Cruise Only

8 Day Itinerary aboard MS Amastella
  • See Strasbourg's Gothic Cathedral
  • Enjoy Heidelberg's natural beauty
  • Hike through Rüdesheim
  • Admire Amsterdam's canals
Activity Level
Variable
From Basel, Switzerland to Amsterdam, the Netherlands, this classic 8-day cruise of the Rhine & Moselle Rivers aboard the MS Amastella will take you through scenic wine country, where you can visit, hike, and tour the historic towns, museums, and canals of Breisach, Strasbourg, Manheim & Heidelberg, the castles of Rüdesheim, and Koblenz & Cologne.
Cruise Details
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River through Koblenz Germany
from $2,543
EXPLORE

The Valley of the romantic Rhine, the Moselle and the Main

Strasbourg Roundtrip - 7 Day Itinerary aboard MS Gérard Schmitter
  • Cruise Iffezheim & Gambsheim locks
  • Enjoy Strasbourg at night
  • Visit the unique Reichsburg Castle
  • Join an exclusive wine tasting
Activity Level
Variable
Explore the enchanting cities of Strasbourg, Frankfurt, Cochem, Koblenz, Rudesheim and Mannheim on this 7-day river cruise aboard the MS Gérard Schmitter. As you travel the Rhine, Moselle, and Main rivers, you'll have the chance to tour ancient towns, bike through verdant valleys, savor the local wines, and explore castles.
Cruise Details
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Historic old town Strasbourg
from $1,995
EXPLORE

The Valley of the Romantic Rhine, the Moselle and the Main

Strasbourg Roundtrip - 7 Day Itinerary aboard MS Monet
  • Frankfurt skyline tower views
  • Koblenz old town exploration
  • Rhine river scenic sailing
  • Heidelberg castle historic tour
Starts / Ends
Strasbourg / Strasbourg
Activity Level
Variable
Sail a Rhine and Moselle route from Strasbourg to Mannheim on a 7-day river cruise ship aboard MS Monet. Visit Frankfurt, Cochem, Koblenz, Rüdesheim, and Heidelberg. Tour castles, walk vineyards, explore old towns, and enjoy dining, entertainment, and scenic cruising.
Cruise Details
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Strasbourg at dusk
from $1,995
EXPLORE

The Valley of the Romantic Rhine, the Moselle and the Main

Strasbourg Roundtrip - 7 Day Itinerary aboard MS La Boheme
  • Enjoy Strasbourg at night
  • Visit Cochem, Pearl of the Moselle
  • See the unique Reichsburg Castle
  • Discover the famous Lorelei Rock
Starts / Ends
Strasbourg / Strasbourg
Activity Level
Variable
Discover three extraordinary rivers: the enchanting Rhine, the graceful Moselle, and the charming Main, on this incredible 7-day cruise aboard La Boheme exploring this romantic region. Delight yourself with the enchanting city of Frankfurt with its mix of ancient and modern sites that are sure to astonish you.
Cruise Details
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Traditional colorful houses in La Petite France, Strasbourg, Alsace, France.
from $7,740
Save 10%
EXPLORE

Rhine River: Castles, Culture and Culinary Delights

Basel - Cologne - 8 Day Itinerary aboard Connect
  • Tour Strasbourg’s Old Town
  • Wine tasting in Alsace
  • See Gutenberg’s Bible
  • Walk Black Forest trails
Starts / Ends
Basel / Cologne
Activity Level
Variable
Sail from Basel to Cologne aboard Connect on this 8-day European river cruise, journey through Switzerland, Germany, and France, discovering medieval towns, scenic vineyards, and cultural landmarks.
Cruise Details
0
Heidelberg
from $7,619
EXPLORE

Rhine & Moselle Delights

15 Day Itinerary aboard MS Amaprima
  • Cruise tranquil Lake Lucerne
  • Explore Strasbourg on foot
  • Visit Trier, Germany’s oldest city
  • Admire Amsterdam's beauty
Activities
Land & Sea Exploration
Activity Level
Variable
This 15-day Rhine & Moselle River cruise aboard MS Amaprima takes you from Zurich to Basel to Amsterdam, passing through Germany and France along the way. Hike and bike in the lush Rhine Valley, stroll the "Crossroads of Europe" in Strasbourg, and savor the best wines and beers that have made this region famous.
Cruise Details
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Trier
from $5,959
EXPLORE

Rhine & Moselle Delights - Cruise Only

11 Day Itinerary aboard MS Amaprima
  • Explore “La Petite France”
  • Bike along the Rhine River
  • Discover Porta Nigra's secrets
  • Enjoy the fairytale town of Cochem
Starts / Ends
Basel / Amsterdam
Activity Level
Variable
Begin this exclusive 11-day cruise in Basel and conclude in charming Amsterdam. This voyage includes a large variety of activities so that you can choose how you want to explore the wondrous delights of the Rhine and Moselle River regions.
Cruise Details
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Stop in beautiful Basel, Switzerland
from $5,749
EXPLORE

Castles along the Rhine

Basel - Amsterdam - 8 Day Itinerary aboard S.S. Antoinette
  • Discover Alsatian wine villages
  • Visit Marksburg Castle in Koblenz
  • Savor Rieslings at Castle Vollrads
  • Explore Cologne's historic center
Starts / Ends
Basel / Amsterdam
Activity Level
Variable
Embark on an 8-day Rhine River cruise from Basel to Amsterdam aboard the S.S. Antoinette. Discover the charm of medieval towns like Breisach and Braubach, explore the cobbled streets of Strasbourg, and visit the majestic Marksburg Castle. Delight in guided walking tours, bike rides along the Rhine, and panoramic views from cable cars.
Cruise Details
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Old city of Koblenz by night
from $1,388
Save 50%
EXPLORE

The Romantic Rhine Valley and the Rock of Lorelei

Strasbourg Roundtrip - 5 Day Itinerary aboard MS Monet
  • Take a tour of Old Strasbourg
  • Enjoy the romance of the Rhine
  • Sail through French & German towns
Starts / Ends
Strasbourg / Strasbourg
Activity Level
Variable
Experience the Rhine Valley on this 5-day round-trip river cruise from Strasbourg, France aboard the MS Monet. As you visit the towns of Koblenz, Mainz, Rudesheim, and Manheim, you'll visit iconic sites like Heidelberg, Stolzenfels Castle, and the quaint villages & savory wineries that characterize the Rhine Valley.
Cruise Details
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Ehrenfels Castle on Rhine River near Rudesheim
from $1,348
Save 50%
EXPLORE

The Romantic Rhine Valley and the Rock of Lorelei

Strasbourg Roundtrip - 5 Day Itinerary aboard MS La Boheme
  • Explore the old Strasbourg at night
  • Visit the famous Drosselgasse
  • Enjoy a tasting of local wines
Starts / Ends
Strasbourg / Strasbourg
Activity Level
Variable
Explore Northern Europe in a new and fascinating way by cruising along the romantic Rhine Valley on a 5-day voyage aboard the MS La Boheme. Making stops in Koblenz, Rudesheim and Speyer. Along the way, tour the canals of Strasbourg, the mechanical music cabinet museum in Rüdesheim, and the Drosselgasse's numerous cafés and bars.
Cruise Details
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Western Church with water canal view in Amsterdam
from $5,999
EXPLORE

Castles along the Rhine

Basel to Amsterdam - 8 Day Itinerary aboard S.S Elisabeth
  • Explore Breisach wine region
  • Visit Rüdesheim’s vineyards
  • Uncover Koblenz & Deutsches Eck
  • Tour Cologne’s Old Town
Starts / Ends
Basel / Amsterdam
Activities
Biking, Local Market Visits
Activity Level
Variable
During this 8-day Rhine River cruise aboard the S.S. Elisabeth, cruise from Basel to Amsterdam, visiting Breisach, Strasbourg, Speyer, Rüdesheim, Koblenz, and Cologne. Enjoy guided tours, wine tastings, scenic cruising, and cultural experiences across Switzerland, France, and Germany in 8 unforgettable days.
Cruise Details
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Ehrenfels Castle on Rhine River near Rudesheim
from $5,049
EXPLORE

Enchanting Rhine - Cruise Only

Basel - Amsterdam - 8 Day Itinerary aboard MS Amalucia
  • Explore Heidelberg's castle views
  • Savor Rudesheim's famed Riesling
  • Stroll Strasbourg's streets
  • Discover Breisach's scenic past
Starts / Ends
Basel / Amsterdam
Activities
Hiking
Activity Level
Variable
Embark on an 8-day river cruise aboard the MS Amalucia, exploring cities where rich history meets modern progress. Journey along the scenic Rhine, passing 40 castles, timeless traditions, and inspiring towns like Heidelberg, where Mark Twain wrote A Tramp Abroad.
Cruise Details
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International Lyceum of Pontonniers in Strasbourg
from $1,668
EXPLORE

The Romantic Rhine Valley and the Rock of Lorelei

Strasbourg Roundtrip - 5 Day Itinerary aboard MS Mona Lisa
  • Explore the old Strasbourg at night
  • Visit the famous Drosselgasse
  • Enjoy a tasting of local wines
Starts / Ends
Strasbourg / Strasbourg
Activity Level
Variable
Join the MS Mona Lisa on a spectacular 5-day voyage. Making stops in Koblenz, Rudesheim, and Mannheim. Along the way, tour the canals of Strasbourg, the mechanical music cabinet museum in Rudesheim and the Drosselgasse's numerous cafés and bars.
Cruise Details
0
Historic old town Strasbourg
from $2,043
EXPLORE

4 Rivers: The Moselle, Sarre, Romantic Rhine, and Neckar Valleys (Port-to-port cruise)

Luxembourg to Strasbourg - 7 Day Itinerary aboard MS Leonardo Da Vinci
  • Enjoy a Luxembourg city guided tour
  • Experience wine tasting in Remich
  • Explore Roman sites in Trier
  • Stroll in Koblenz's old town
Starts / Ends
Luxembourg / Strasbourg
Activities
Village Visits, Wine Tasting, Urban Exploration, Archaeological Site Visits
Activity Level
Variable
Embark on a 7-day river cruise aboard MS Leonardo Da Vinci from Luxembourg to Strasbourg along the Moselle, Rhine, and Neckar Rivers. Explore Trier’s Roman heritage, Cochem Castle, Koblenz, Rudesheim vineyards, and Heidelberg’s historic charm. Enjoy wine tastings, guided tours, and lively evenings on board.
Cruise Details
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Historic Zurich with River Limmat, Switzerland
from $6,809
EXPLORE

Enchanting Rhine

Zurich - Amsterdam - 12 Day Itinerary aboard MS Amastella
  • Wander Strasbourg’s charming street
  • Discover Basel’s historical gems
  • Stroll medieval walls in Lucerne
  • Explore Zurich’s vibrant history
Activity Level
Variable
Sail the Rhine on a 12-day cruise with stays in Zurich and Lucerne aboard the MS Amastella. Explore vibrant cities, storybook towns, and a UNESCO-listed landscape of castles, breweries, and timeless traditions.
Cruise Details
0
Old city of Koblenz by night
from $11,190
EXPLORE

Rhine Highlights

Amsterdam - Basel - 8 Day Itinerary aboard Scenic Pearl
  • Admire Cologne's cathedral
  • Cruise Europe’s beautiful rivers
  • Discover history of Heidelberg
  • Enjoy Amsterdam’s canals
Starts / Ends
Amsterdam / Basel
Activity Level
Variable
Experience an enriching 8-day cruise from Amsterdam to Basel on the Scenic Pearl, uncovering historic cities and scenic towns along the Rhine. Enjoy Amsterdam's canals, Koblenz's culture, Cochem's vineyards, Baden-Baden's thermal spa, and Strasbourg's unique architecture.
Cruise Details
0
Historic old town Strasbourg
from $11,190
EXPLORE

Rhine Highlights

Amsterdam - Basel - 8 Day Itinerary aboard Scenic Ruby
  • Discover history of Heidelberg
  • Admire Cologne's cathedral
  • Wander Amsterdam’s canals
  • Cruise Europe’s beautiful rivers
Starts / Ends
Amsterdam / Basel
Activity Level
Variable
Experience an enriching 8-day cruise from Amsterdam to Basel on the Scenic Ruby, uncovering historic cities and scenic towns along the Rhine. Enjoy Amsterdam's canals, Koblenz's culture, Cochem's vineyards, Baden-Baden's thermal spa, and Strasbourg's unique architecture.
Cruise Details
0
Ehrenfels Castle on Rhine River near Rudesheim
from $2,606
EXPLORE

5 Different Rivers: The Rhine, Neckar, Main, Moselle, and Saar (Port-to-port cruise)

Strasbourg to Luxembourg - 9 Day Itinerary aboard MS Leonardo Da Vinci
  • Enjoy Heidelberg Castle guided tour
  • Rudesheim vineyard wine tasting
  • Enjoy Rhine Valley scenic sailing
  • Explore Saarburg’s old town
Starts / Ends
Strasbourg / Remich
Activity Level
Variable
Set sail on a 9-day Rhine and Moselle river cruise from Strasbourg to Luxembourg aboard MS Leonardo Da Vinci. Discover Heidelberg Castle, Mainz Cathedral, and Trier’s Roman ruins. Explore Frankfurt, Rüdesheim’s vineyards, Cochem Castle, and Luxembourg’s historic city center. Enjoy wine tastings, guided tours, and unique cultural landmarks.
Cruise Details
0
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