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Top Mannheim Trips & Tours in September 2025

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Discover Mannheim in September 2025 on one of these 11 tours hand-selected by the travel experts at Adventure Life. Explore the best of during September 2025 as you enjoy Wine Tasting, Hiking, Biking, Village Visits, and Archaeological Site Visits. Prices for trips in September 2025 range from $1,850 to $12,499 for a vacation of 5 to 15 days. Choose any of the below 11 itineraries in September 2025 and customize it when you contact one of Adventure Life's expert Mannheim trip planners.
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Historic old town Strasbourg
from $1,850
EXPLORE

The Romantic Rhine Valley and the Rock of Lorelei

Strasbourg Roundtrip - 5 Day Itinerary aboard MS Gérard Schmitter
Starts / Ends
Strasbourg / Strasbourg
Activity Level
Variable
Get to know the scenic Rhine River on this 5-day river cruise aboard the MS Gerard Schmitter. From Strasbourg, France to Rudesheim, Germany and back, you'll see the Rock of Lorelei, visit vineyards and traditional cafes cellar, and see museums & neighborhoods like those of Heidelberg, Mainz, Koblenz, and Speyer.
  • Explore the Stolzenfels Castle
  • Visit the Bassenheimer Hof cellar
  • Enjoy the views of Rüdesheim
Cruise Details
0
Stop in beautiful Basel, Switzerland
from $5,099
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Castles along the Rhine

Basel - Amsterdam - 8 Day Itinerary aboard S.S. Antoinette
Starts / Ends
Basel / Amsterdam
Activities
Archaeological Site Visits
Activity Level
Variable
Embark on an 8-day Rhine River cruise from Basel to Amsterdam aboard the S.S. Antoinette. Discover the charm of medieval towns like Breisach and Braubach, explore the cobbled streets of Strasbourg, and visit the majestic Marksburg Castle. Delight in guided walking tours, bike rides along the Rhine, and panoramic views from cable cars.
  • Discover Alsatian wine villages
  • Visit Marksburg Castle in Koblenz
  • Savor Rieslings at Castle Vollrads
  • Explore Cologne's historic center
Cruise Details
0
View of Strasbourg city
from $4,639
CLP
EXPLORE

Enchanting Rhine - Cruise Only

8 Day Itinerary aboard MS Amastella
Activity Level
Variable
From Basel, Switzerland to Amsterdam, the Netherlands, this classic 8-day cruise of the Rhine & Moselle Rivers aboard the MS Amastella will take you through scenic wine country, where you can visit, hike, and tour the historic towns, museums, and canals of Breisach, Strasbourg, Manheim & Heidelberg, the castles of Rüdesheim, and Koblenz & Cologne.
  • See Strasbourg's Gothic Cathedral
  • Enjoy Heidelberg's natural beauty
  • Hike through Rüdesheim
  • Admire Amsterdam's canals
Cruise Details
0
Heidelberg
from $7,399
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Rhine & Moselle Delights

15 Day Itinerary aboard MS Amaprima
Activities
Land & Sea Exploration
Activity Level
Variable
This 15-day Rhine & Moselle River cruise aboard MS Amaprima takes you from Zurich to Basel to Amsterdam, passing through Germany and France along the way. Hike and bike in the lush Rhine Valley, stroll the "Crossroads of Europe" in Strasbourg, and savor the best wines and beers that have made this region famous.
  • Cruise tranquil Lake Lucerne
  • Explore Strasbourg on foot
  • Visit Trier, Germany’s oldest city
  • Admire Amsterdam's beauty
Cruise Details
0
Trier
from $5,539
CLP
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Rhine & Moselle Delights - Cruise Only

11 Day Itinerary aboard MS Amaprima
Starts / Ends
Basel / Amsterdam
Activity Level
Variable
Begin this exclusive 11-day cruise in Basel and conclude in charming Amsterdam. This voyage includes a large variety of activities so that you can choose how you want to explore the wondrous delights of the Rhine and Moselle River regions.
  • Explore “La Petite France”
  • Bike along the Rhine River
  • Discover Porta Nigra's secrets
  • Enjoy the fairytale town of Cochem
Cruise Details
0
Ehrenfels Castle on Rhine River near Rudesheim
from $4,639
CLP
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Enchanting Rhine - Cruise Only

Basel - Amsterdam - 8 Day Itinerary aboard MS Amalucia
Starts / Ends
Basel / Amsterdam
Activities
Wine Tasting, Village Visits, Hiking, Biking, Local Market Visits
Activity Level
Variable
Embark on an 8-day river cruise aboard the MS Amalucia, exploring cities where rich history meets modern progress. Journey along the scenic Rhine, passing 40 castles, timeless traditions, and inspiring towns like Heidelberg, where Mark Twain wrote A Tramp Abroad.
  • Explore Heidelberg's castle views
  • Savor Rudesheim's famed Riesling
  • Stroll Strasbourg's streets
  • Discover Breisach's scenic past
Cruise Details
0
Old city of Koblenz by night
from $10,590
2for1
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Rhine Highlights

Amsterdam - Basel - 8 Day Itinerary aboard Scenic Pearl
Starts / Ends
Amsterdam / Basel
Activity Level
Variable
Experience an enriching 8-day cruise from Amsterdam to Basel on the Scenic Pearl, uncovering historic cities and scenic towns along the Rhine. Enjoy Amsterdam's canals, Koblenz's culture, Cochem's vineyards, Baden-Baden's thermal spa, and Strasbourg's unique architecture.
  • Admire Cologne's cathedral
  • Cruise Europe’s beautiful rivers
  • Discover history of Heidelberg
  • Enjoy Amsterdam’s canals
Cruise Details
0
Spring flowers in Mannheim
from $10,590
2for1
EXPLORE

Rhine Highlights

Amsterdam - Basel - 8 Day Itinerary aboard Scenic Jasper
Starts / Ends
Amsterdam / Basel
Activity Level
Variable
Experience an enriching 8-day cruise from Amsterdam to Basel on the Scenic Jasper, uncovering historic cities and scenic towns along the Rhine. Enjoy Amsterdam's canals, Koblenz's culture, Cochem's vineyards, Baden-Baden's thermal spa, and Strasbourg's unique architecture.
  • Explore Amsterdam’s canals
  • Discover the history of Heidelberg
  • Enjoy Europe’s Rhine river
  • Stroll through Cologne
Cruise Details
0
Historic Zurich with River Limmat, Switzerland
from $6,499
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Enchanting Rhine

Zurich - Amsterdam - 12 Day Itinerary aboard MS Amastella
Activity Level
Variable
Sail the Rhine on a 12-day cruise with stays in Zurich and Lucerne aboard the MS Amastella. Explore vibrant cities, storybook towns, and a UNESCO-listed landscape of castles, breweries, and timeless traditions.
  • Wander Strasbourg’s charming street
  • Discover Basel’s historical gems
  • Stroll medieval walls in Lucerne
  • Explore Zurich’s vibrant history
Cruise Details
0
View of Strasbourg city
from $4,639
x3 Savings
EXPLORE

Captivating Rhine - Cruise Only

8 Day Itinerary aboard MS Amalucia
Activities
Urban Exploration
Activity Level
Variable
Enjoy two days in Amsterdam, then embark on the MS Amalucia for an 8-day cruise from Amsterdam to Basel, Switzerland, exploring the fascinating towns of Cologne, Rudesheim, Strasbourg, and Breisach along the Rhine River.
  • Take an Amsterdam canal tour
  • Enjoy optional excursions
  • Hike up the Philosopher's Path
  • Explore Strasbourg
Cruise Details
0
Strasbourg
from $4,639
x3 Savings
EXPLORE

Captivating Rhine - Cruise Only

Amsterdam - Basel - 8 Day Itinerary aboard MS Amastella
Activity Level
Variable
Sail from Amsterdam to Basel on an 8-day Rhine River cruise aboard the MS Amastella, passing vineyard-clad hills and fairytale castles. Explore charming towns, savor local flavors, and experience the beauty of Alsace, the Black Forest, and beyond.
  • Savor wines in Rudesheim’s vineyard
  • Cruise Amsterdam's scenic canals
  • Explore Dusseldorf’s vibrant charm
  • Wander Strasbourg’s Petite France
Cruise Details
0
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