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Cruises Operated by American Cruise Lines, Inc.

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Experience cruise tailored to adventurous and discerning travelers. With 45 unique itineraries available between 2026 and 2029, guests can explore top destinations like Baton Rouge, Memphis, Natchez, Vicksburg, and New Orleans, while enjoying curated activities such as Archaeological Site Visits, Wildlife Viewing, Urban Exploration, Village Visits, and Local Market Visits. Whether you prefer short getaways or extended explorations, trips range from 7 days to 23 days, with pricing from $3,630 to $27,915. is known for exceptional service, small-ship intimacy, and flexible policies designed to ensure a smooth travel experience. Ideal for solo travelers, couples, or small groups, cruises in 2026 and 2027 offer a perfect blend of comfort, discovery, and unforgettable memories.
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Tennessee
from $6,600
Savings
EXPLORE

Music Cities Cruise

Memphis, TN to Nashville, TN - 9 Day Itinerary aboard American Symphony
  • Discover Memphis live music scene
  • Witness scenic cliffs
  • See Nashville’s iconic Hall of Fame
  • Walk at Clarksville’s streets
Starts / Ends
Memphis / Nashville
Activity Level
Variable
Travel from Memphis to Nashville on a 9-day river cruise aboard American Symphony. Enjoy live onboard music, explore cities like Paducah and Clarksville, and visit landmarks such as Fort Donelson and the Grand Ole Opry. Experience music, history, and river scenery through curated excursions and onboard activities.
Cruise Details
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Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $12,620
Savings
EXPLORE

Grand Heartland Cruise

Minnesota - Louisiana - 16 Day Itinerary aboard American Serenade
  • Visit mansions and art galleries
  • See the Gateway Arch and St. Louis
  • Visit Natchez’s antebellum homes
  • Experience Memphis' musical legacy
Starts / Ends
St. Paul / New Orleans
Activity Level
Variable
Embark on a 16-day Mississippi River cruise from Minnesota to Louisiana aboard American Serenade, exploring St. Paul to New Orleans with stops in La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, and Natchez. Enjoy onboard activities, stunning scenery, and experiences like the Mark Twain Boyhood Home and more.
Cruise Details
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View monuments from the Civil War in Mississippi
from $4,610
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Heritage
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Starts / Ends
Memphis / New Orleans
Activity Level
Variable
Embark on a 9-day cruise aboard American Heritage from Memphis to New Orleans along the Lower Mississippi River. Visit Cleveland, Vicksburg, Natchez, Baton Rouge, and Oak Alley. Explore Civil War landmarks, historic homes, museums, plantations, and Louisiana wetlands while discovering the history, music, and culture of the American South.
Cruise Details
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Explore beautiful Portland
from $14,060
Savings
EXPLORE

National Parks & Legendary Rivers

Portland,OR - Jackson,WY - 16 Day Itinerary aboard American Song
  • Explore Astoria and The Dalles town
  • Visit Mount St. Helens volcano site
  • Jet boat through Hells Canyon gorge
  • Discover Glacier & Yellowstone Park
  • Explore Grand Teton lakes and peaks
Starts / Ends
Portland / Jackson Hole
Activities
Archaeological Site Visits, Wildlife Viewing, Local Market Visits, Urban Exploration, Land & Sea Exploration
Activity Level
Variable
Discover national parks and legendary rivers on a 16-day land and river cruise from Portland to Jackson. Cruise the Columbia and Snake Rivers, visit Astoria and The Dalles, see Mount St. Helens, and explore Hells Canyon. Continue to Glacier, Yellowstone, and Grand Teton National Parks with guided tours, meals, and select stays.
Cruise Details
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Columbia River Gorge
from $6,400
Savings
EXPLORE

Columbia & Snake Rivers Cruise

Portland - Clarkston - 9 Day Itinerary aboard American Song
  • Explore Astoria's Victorian charm
  • Step ashore in Kalama
  • Discover Richland's scenic trails
  • Cruise the legendary Snake River
Starts / Ends
Portland / Clarkston
Activity Level
Variable
Embark on a 9-day cruise aboard American Song, navigating the Columbia & Snake Rivers. Cruise past Mount Hood, reliving the golden age of riverboats. Explore Astoria's Victorian charm and visit Fort Clatsop. Journey through history in The Dalles, Richland, and Pendleton, culminating in the majestic landscapes of Hells Canyon.
Cruise Details
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Explore Pittsburgh
from $6,215
Savings
EXPLORE

Ohio River Cruise

Pittsburgh - Louisville - 9 Day Itinerary aboard American Melody
  • Learn Pittsburgh steel city history
  • See Wheeling Victorian architecture
  • Ohio River scenic cruise
  • Visit Louisville Slugger Museum
Starts / Ends
Pittsburgh / Louisville
Activity Level
Variable
Embark on a 9-day Ohio River cruise from Pittsburgh to Louisville aboard American Melody. Explore Wheeling, Marietta, Cincinnati, Madison, and more. Discover historic architecture, museums, riverfront views, and cultural attractions while enjoying onboard activities, local cuisine, and scenic river landscapes.
Cruise Details
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Explore historic Boston
from $6,710
Savings
EXPLORE

Cape Codder Cruise

Boston, MA Roundtrip - 9 Day Itinerary aboard American Glory
  • Walk Boston’s Freedom Trail
  • Tour Newport’s grand mansions
  • Enjoy Martha’s Vineyard Museum
  • See massive whale skeletons
Starts / Ends
Boston / Boston
Activity Level
Variable
Embark on an 9-day Cape Cod cruise aboard American Glory, round-trip from Boston. Visit Provincetown, Plymouth, Martha’s Vineyard, Newport, and New Bedford. Step into colonial history, maritime culture, and coastal scenery.
Cruise Details
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Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $5,635
Savings
EXPLORE

Upper Mississippi River

St. Paul, MN - St. Louis, MO - 9 Day Itinerary aboard American Serenade
  • Tour historic Summit Avenue
  • Explore Dubuque River Museum
  • Experience John Deere Pavilion
  • Visit Mark Twain’s boyhood home
Starts / Ends
St. Paul / St. Louis
Activities
Wine Tasting, Biking, Village Visits
Activity Level
Variable
Set sail for 9 days aboard American Serenade from St. Paul to St. Louis. Walk through historic Summit Avenue, admire La Crosse from Grandad’s Bluff, explore Dubuque’s River Museum, and discover Mark Twain’s legacy in Hannibal. Experience curated onboard programs, live music, and the beauty of the Upper Mississippi’s diverse wildlife.
Cruise Details
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Explore beautiful Alaska
from $16,975
Savings
EXPLORE

Grand Alaska National Parks

Fairbanks, AK​ to Juneau, AK - 19 Day Itinerary aboard American Constellation
  • Glacier Bay ice views
  • Visit Denali National Park
  • Experience Sitka historic park walk
  • See the Kenai Fjords and wildlife
Starts / Ends
Fairbanks / Juneau
Activities
Whale Watching, Hiking, Kayaking
Activity Level
Variable
Experience Alaska on a comprehensive 19-day land and cruise journey aboard American Constellation. Travel through Fairbanks, Denali, Anchorage, Seward, Juneau, Glacier Bay, Sitka, Petersburg, Wrangell, and Frederick Sound. Explore national parks, encounter wildlife, and join guided cultural tours across Alaska’s most iconic landscapes.
Cruise Details
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Get up close to amazing glaciers in Alaska
from $14,425
Savings
EXPLORE

Alaska National Parks

Fairbanks - Juneau - 16 Day Itinerary aboard American Constitution
  • Fairbanks cultural touring
  • View Denali wildlife
  • Ride a glass-domed train
  • Watch bald eagles in Haines
Starts / Ends
Fairbanks / Juneau
Activity Level
Variable
Embark a 16-day Alaska land and sea journey from Fairbanks to Juneau aboard American Constitution. Explore Denali, Kenai Fjords, Glacier Bay, Haines, Petersburg, Wrangell, and Endicott Arm. Ride a dome train, watch whales and glaciers, and enjoy expert-led excursions with rare access to protected waters.
Cruise Details
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View the iconic arch when you visit St. Louis, gateway to the west
from $9,920
Savings
EXPLORE

Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody
  • Explore historic Marietta, Ohio
  • Explore Maysville’s Railroad
  • Visit Louisville’s Churchill Downs
  • Tour Paducah’s wall murals
Starts / Ends
Pittsburgh / St. Louis
Activity Level
Variable
Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.
Cruise Details
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Grinnell Valley in Glacier National Park
from $14,395
Savings
EXPLORE

National Parks & Legendary Rivers

Portland, OR to Jackson, WY - 16 Day Itinerary aboard American Jazz
  • Cruise Columbia River Gorge
  • Visit Mount St. Helens
  • Enjoy Richland wine tastings
  • Discover Yellowstone’s geysers
Starts / Ends
Portland / Grand Teton National Park
Activity Level
Variable
Embark on a 16-day combined Columbia and Snake Rivers cruise aboard American Jazz and land tour through iconic national parks, Glacier, Yellowstone, and Grand Teton National Parks. Explore vibrant towns, hike scenic trails, visit historic landmarks, and enjoy wine tastings, nature tours, and enriching excursions.
Cruise Details
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1-12 of 45 Results

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TrustScore 4.8 | 1006 reviews
TrustScore 4.8 of 5
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Based on 1006 reviews on
review score
21 hours ago
Critical reminders for deadline dates.
Rosemary Huebner
review score
2 days ago
It was a great experience arranging our Svalbard wildlife cruise (Around Spitzbergen - in the reals of polar bear and ice, on MV Plancius) with Adventure Life. They are very reliable with information and trustworthy with payment handling. We organised this trip one year ahead and we were kept up to date all the way. Our dedicated travel advisor, Chloe made our travel experience extra convenient and super easy. Very happy with Adventure Life's service and support. Would recommend them 100% to everybody.❤️
Aindrila Chakrabarti
review score
4 days ago
Very responsive and helpful with determining appropriate trip for my budget and travel desires! Thank you 🙏🏻
Abby K
review score
5 days ago
This is my fourth trip with Adventure Life and, as in the past, the staff was very knowledgeable and helpful. they talk with you about your desires and provide excellent suggestions.
Robert Thompson
review score
1 week ago
We are a large group of several families, yet Claudia kept us informed and on deadline so that we could receive a discount. She was consistently pleasant and efficient. Would happily work with her again.
Valerie Brewer

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