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The state of Louisiana is where the Mississippi River meets the Gulf of Mexico, and where a mix of cultural influences gave birth to the Creole language and Cajun culture. Set sail on a memorable Cruise from Louisiana, where every journey begins with the rich culture and vibrant energy of New Orleans. Departing from the New Orleans Port Cruise terminals, you’ll join a Mississippi River cruise or venture into the Gulf on immersive itineraries that showcase the Deep South’s charm. These voyages offer a perfect balance of riverfront history, jazz-filled streets, and world-class cuisine—an ideal gateway to explore America’s cultural heartland.
 
Our short or extended voyages stretch upriver to Memphis or even St. Paul and our New Orleans Port Cruise promises scenic days, engaging shore excursions, and relaxed luxury onboard. Enjoy wine tastings, historic plantation visits, and wildlife tours, or wander through the French Quarter before departure. Whether you're a first-time cruiser or a seasoned traveler, our handpicked cruises from Louisiana deliver unforgettable experiences. Book your perfect Louisiana tour and cruise with our Trip Planner now!
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    • Louisiana
Visit Louisiana's capital city of Baton Rouge
from $3,630
Savings
EXPLORE

Highlights of the Mississippi Cruise

New Orleans Roundtrip - 8 Day Itinerary aboard American Heritage
  • Experience Natchez’s beauty
  • Visit historic Civil War sites
  • Discover Oak Alley's historic charm
  • Visit charming ports and cities
Starts / Ends
New Orleans / New Orleans
Activity Level
Variable
The American Heritage hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.
Cruise Details
0
Wander through the historic French Quarter
from $3,999
EXPLORE

New Orleans & Southern Charms

Roundtrip New Orleans - 8 Day Itinerary aboard Viking Mississippi
  • Enjoy Cajun and Creole cuisine
  • Indulge in New Orleans' music
  • Learn the history of Vicksburg
  • See the historic homes of Natchez
Starts / Ends
New Orleans / New Orleans
Activities
Festival Visits
Activity Level
Variable
Explore the highlights of the Mississippi River on this 8-day cruise roundtrip from New Orleans aboard Viking Mississippi. Discover port cities such as St. Francisville, Darrow, Baton Rouge, Natchez, and Vicksburg to experience the diverse culture and rich history of the lower Mississippi region.
Cruise Details
0
Explore historic New Orleans
from $4,255
Savings
EXPLORE

Highlights of the Mississippi Cruise

New Orleans Roundtrip - 8 Day Itinerary aboard American Melody
  • Explore the antebellum of Natchez
  • Visit historic Civil War sites
  • Discover Oak Alley's historic charm
  • Visit charming ports and cities
Starts / Ends
New Orleans / New Orleans
Activity Level
Variable
The American Melody hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.
Cruise Details
0
Natchez
from $4,299
EXPLORE

Mississippi Delta Explorer

New Orleans - Memphis - 8 Day Itinerary aboard Viking Mississippi
  • Explore Darrow
  • Visit Natchez historic sites
  • Learn the history of Vicksburg
  • Culinary adventure of Mississippi
  • Know the history of rock 'n' roll
  • American South's Cultural Heritage
Starts / Ends
New Orleans / Memphis
Activity Level
Variable
On this 8-day Mississippi Delta Explorer from New Orleans to Memphis aboard the Viking Mississippi, visit historic towns like Darrow, Natchez, and Vicksburg. Enjoy Cajun and Creole cuisine, Memphis barbecue, and explore the South’s rich history, culture, and music.
Cruise Details
0
Visit historic Memphis, Tennessee
from $9,999
EXPLORE

The Big Easy to the Gateway City

New Orleans - St. Louis - 15 Day Itinerary aboard Viking Mississippi
  • Explore New Orleans French Quarter
  • Tour Darrow spectacular gardens
  • Enjoy Memphis rich history
  • Discover Natchez historic estates
Starts / Ends
New Orleans / Alton
Activities
Village Visits, Urban Exploration, Archaeological Site Visits
Activity Level
Variable
Discover early 19th-century life and Civil War history on a 15-day cruise aboard the Viking Mississippi. Visit grand plantations, memorials, and key sites of the Civil Rights Movement while enjoying regional traditions along the iconic river.
Cruise Details
0
Enjoy the colorful architecture of New Orleans
from $5,275
Savings
EXPLORE

Lower Mississippi River Cruise

New Orleans - Memphis - 9 Day Itinerary aboard American Melody
  • Explore New Orleans lively culture
  • Discover Oak Alley with landscapes
  • Discover Baton Rouge
  • Visit Graceland Memphis
Starts / Ends
New Orleans / Memphis
Activities
Cooking Classes, Wildlife Viewing
Activity Level
Variable
Embark on a 9-day cruise from New Orleans to Memphis aboard American Melody, exploring Southern culture and history with local guides. Enjoy enriching excursions, gourmet meals, daily cocktails, and captivating shows at historic sites like Vicksburg and Natchez.
Cruise Details
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Vicksburg Battlefield overlooking the Mississippi River
from $4,925
Savings
EXPLORE

Lower Mississippi River Cruise

New Orleans - Memphis - 9 Day Itinerary aboard American Heritage
  • Admire the diversity of New Orleans
  • Visit Oak Alley mansion and avenue
  • Discover Baton Rouge's landmarks
  • Enjoy the music of Memphis
Starts / Ends
New Orleans / Memphis
Activity Level
Variable
Cruise aboard American Heritage on a 9-day cruise from New Orleans to Memphis along the Mississippi River. Visit Oak Alley, Baton Rouge, Natchez, Vicksburg, and Cleveland. Explore historic plantations, Civil War sites, blues landmarks, museums, and riverfront towns while experiencing the culture and history of the American South.
Cruise Details
0
Explore beautiful Nashville
from $5,499
EXPLORE

Nashville, Memphis & the Cumberland

Memphis to Nashville - 8 Day Itinerary aboard Viking Mississippi
  • Discover Memphis blues roots
  • See Paducah murals
  • Walk historic Clarksville streets
  • Cruise Tennessee River scenery
Starts / Ends
Memphis / Nashville
Activities
Wine Tasting
Activity Level
Variable
Take an 8-day Viking Mississippi cruise through Memphis, Cape Girardeau, Paducah, Clarksville, and Nashville. Visit key cultural and historical sites, from music landmarks to Civil War history and regional museums.
Cruise Details
0
View monuments from the Civil War in Mississippi
from $4,610
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Heritage
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Starts / Ends
Memphis / New Orleans
Activity Level
Variable
Embark on a 9-day cruise aboard American Heritage from Memphis to New Orleans along the Lower Mississippi River. Visit Cleveland, Vicksburg, Natchez, Baton Rouge, and Oak Alley. Explore Civil War landmarks, historic homes, museums, plantations, and Louisiana wetlands while discovering the history, music, and culture of the American South.
Cruise Details
0
View the iconic arch when you visit St. Louis, gateway to the west
from $12,999
EXPLORE

America’s Great River

St. Paul to New Orleans - 15 Day Itinerary aboard Viking Mississippi
  • Explore St. Louis' arts scene
  • Enjoy American music styles
  • Learn Civil War history
  • Experience New Orleans' culture
  • Visit the Quad Cities
Starts / Ends
St. Paul / New Orleans
Activity Level
Variable
Cruise America's great river on this 15-day itinerary aboard Viking Mississippi. Journey from St. Paul, Minnesota to New Orleans, Louisiana and explore highlights of the mighty Mississippi River. Along the way, visit historic ports such as St. Louis, Memphis, Baton Rouge, and more.
Cruise Details
0
Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $12,620
Savings
EXPLORE

Grand Heartland Cruise

St. Paul to New Orleans - 16 Day Itinerary aboard American Serenade
  • Cruise Mississippi River scenery
  • Discover Davenport museums
  • Visit Gateway Arch landmark
  • Tour Vicksburg battlefields
Starts / Ends
St. Paul / New Orleans
Activities
Local Market Visits, Biking
Activity Level
Variable
Cruise the Mississippi River on a 16-day voyage aboard American Serenade. Visit La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Tunica, Vicksburg, Natchez, and Baton Rouge while exploring museums, riverfronts, historic landmarks, Civil War sites, and music destinations. Enjoy scenic cruising through the Upper and Lower Mississippi.
Cruise Details
0
Memphis, Tennesse, USA downtown cityscape at dusk over Beale Street
from $5,275
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Symphony
  • Explore Rosalie Mansion and Natchez
  • Visit Baton Rouge landmarks
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Starts / Ends
Memphis / New Orleans
Activity Level
Variable
Experience a 9-day cruise aboard American Symphony from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.
Cruise Details
0
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