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Top Mekong River Trips & Tours in September 2026

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Discover Mekong River in September 2026 on one of these 45 tours hand-selected by the travel experts at Adventure Life. Explore the best of during September 2026 as you enjoy Village Visits, Local Market Visits, Archaeological Site Visits, Biking, and Wildlife Viewing. Prices for trips in September 2026 range from $0 to $25,395 for a vacation of 5 to 16 days. Choose any of the below 45 itineraries in September 2026 and customize it when you contact one of Adventure Life's expert Mekong River trip planners.
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    • Mekong River
Phnom Penh Royal Palace complex
from $1,355
EXPLORE

Mekong River - Upstream

Saigon to Phnom Penh - 4 Day Itinerary aboard The Jahan
  • Observed locals along the river
  • See Cai Be’s rice & candy making
  • Explore the Gieng Island
  • Visit Phnom Penh cultural sites
Starts / Ends
Ho Chi Minh City / Phnom Penh
Activity Level
Variable
On this 4-day journey from Saigon to Phnom Penh, cruise the lower Mekong River in majestic style aboard the Jahan. Discover the culture and history of the various towns along the mighty Mekong while exploring the river.
Cruise Details
0
Everyday life in Vietnam
from $3,449
EBD $4000
EXPLORE

Charms of the Mekong - Cruise Only

Ho Chi Minh - Siem Reap - 8 Day Itinerary aboard MS Amadara
  • Explore Cai Be’s vibrant workshops
  • Discover Sa Dec history
  • Visit Phnom Penh landmarks
  • Experience Oknhatey, silk weaving
Starts / Ends
Ho Chi Minh City / Siem Reap
Activity Level
Variable
Embark on an 8-day river cruise aboard the MS Amadara, starting in Ho Chi Minh City, a vibrant blend of history and modernity. Cruise the Mekong River, exploring villages, pagodas, and markets and experiencing local traditions, including a monk’s blessing and artisan crafts.
Cruise Details
0
The colorful Tonle Sap village
from $10,570
EXPLORE

Mekong Expedition - Ho Chi Minh to Siem Reap (Extension)

Low water - 8 Day Itinerary aboard Aqua Mekong
  • Discover My An Hung
  • Enjoy a traditional performance
  • Learn to cook Mekong dishes
  • Visit Cambodia's National Museum
  • Past by Buddhist temples
Activity Level
Variable
From Ho Chi Minh, Vietnam to Phnom Penh, Cambodia, luxurious Aqua Mekong takes you on this 8-day Mekong River cruise, visiting Buddhist temples, local villages & markets, and touring Chau Doc, Kampong Chhnang, Kampong Tralach, Koh Oknha Tey, and Sa Dec.
Cruise Details
0
Explore the floating village of Tonle Sap
from $10,570
EXPLORE

Mekong Expedition - Phnom Penh to Ho Chi Minh

8 Day Itinerary aboard Aqua Mekong
  • Walk across Kampong Prasat
  • Learn more about the local products
  • Visit the Tuol Sleng Museum
  • Discover Tan Chau
Starts / Ends
Phnom Penh / Ho Chi Minh City
Activities
Kayaking
Activity Level
Variable
Admire the diverse cultures and stunning natural beauty of Cambodia & Vietnam on this 8-day river cruise aboard Aqua Mekong. Hikes and bike rides complement cultural tours and market visits as you explore the cities & sites of Cai Be, Chau Doc, Ho Chi Minh City, Kampong Chhnang, Kampong Tralach, Koh Chen, and Phnom Penh.
Cruise Details
0
Royal Palace and Silver Pagoda
from $1,354
EXPLORE

Mekong River - Downstream

Phnom Penh to Saigon - 4 Day Itinerary aboard Jayavarman
  • Observed locals along the river
  • Aboard a luxury riverboat in Mekong
  • Visit Phnom Penh cultural sites
  • Visit the Gieng Island
Starts / Ends
Phnom Penh / Ho Chi Minh City
Activity Level
Variable
Cruise downstream on the Mekong River in majestic style aboard the Jayavarman on this 4-day journey from Phnom Penh to Saigon. Learn about the culture and heritage with visits to rural villages, historic pagodas, and colorful markets
Cruise Details
0
Vietnam's bird sanctuary
from $10,570
EXPLORE

Mekong Expedition - Ho Chi Minh to Siem Reap

High water - 8 Day Itinerary aboard Aqua Mekong
  • Experience vibrant markets
  • Enjoy touring Cambodia's capital
  • Visit Long Son Pagoda
  • Explore Prek Toal Core Bird Reserve
Starts / Ends
Ho Chi Minh City / Siem Reap
Activity Level
Variable
Board the Aqua Mekong for an unforgettable 8-day cruise up the Mekong River from Saigon, Vietnam, to Siem Reap, Cambodia, with stops in Phnom Penh and Tonle Sap Lake, among other highlights of the Indochina peninsula. Biking, hiking, cultural immersion, market visits, and cooking classes highlight the cruise.
Cruise Details
0
Traditional mat-making
from $1,355
EXPLORE

Mekong River - Downstream

Phnom Penh to Saigon - 4 Day Itinerary aboard The Jahan
  • Hear Khmer Rouge survivor story
  • Explore Gieng Island
  • Explore My An Hung Village
  • Discover water hyacinth weaving
  • Experience Tan Phong Island
Starts / Ends
Phnom Penh / Ho Chi Minh City
Activities
Biking
Activity Level
Variable
On this 4-day journey from Phnom Penh to Saigon, cruise downstream on the lower Mekong River in majestic style aboard the Jahan. See the stunning scenery and discover the culture and history of the various towns along the mighty Mekong.
Cruise Details
0
Woman on a boat in Vietnam
from $2,659
EXPLORE

From the Mekong Delta to Siem Reap

Ho Chi Minh City - Siem Reap - 9 Day Itinerary aboard RV Indochine II
  • Join a tour of Ho Ci Minh City
  • Observe Chau Doc´s vibrant market
  • Experience a trip in a “tuk tuk”
  • See Kampong Chhnang´s fish farms
Activity Level
Variable
Discover the culture and history of Vietnam & Cambodia on this 9-day cruise from Ho Chi Minh City to Siem Reap aboard the RV Indochine II, departing from Vietnam's Ho Chi Minh City towards Cambodia's Siem Reap, with stops in My Tho & Phnom Penh along the way.
Cruise Details
0
Enjoy the Mekong’s tranquil waters as colorful blooms and a rustic riverside home set a relaxed, local vibe.
from $3,349
EBD $4000
EXPLORE

Riches of the Mekong - Cruise Only

8 Day Itinerary aboard MS Amadara
  • Explore Angkor Ban village
  • Visit Oknhatey, Silk Island
  • Tour Phnom Penh highlights
  • Discover Oudong, royal capital
Starts / Ends
Siem Reap / Ho Chi Minh City
Activities
Wildlife Viewing
Activity Level
Variable
Embark on an 8-day river cruise from Siem Reap to Ho Chi Minh aboard the MS Amadara, exploring rural villages, bustling markets, and historic sites. Experience Cambodia and Vietnam’s rich culture through artisan crafts, temple visits, and unique rides by oxcart, tuk-tuk, and trishaw.
Cruise Details
0
The floating village of Tonle Sap, Cambodia
from $6,400
EXPLORE

Mekong Explorer - Ho Chi Minh to Siem Reap (Extension)

5 Day Itinerary aboard Aqua Mekong
  • Enjoy a visit to a local's home
  • Walk through verdant plantations
  • Meet & interact with Buddhist Monks
  • Bike through Long Khanh
Starts / Ends
Ho Chi Minh City / Phnom Penh
Activity Level
Variable
Board the Aqua Mekong in My Tho for a 5-day Mekong River cruise of Cambodia & Vietnam, including stops in Ho Chi Minh City, Phnom Penh, and Long Son Pagoda atop Sam Mountain. Travel back in time as you cruise upriver through the thriving Mekong Delta past floating villages, colonial vestiges, and gilded pagodas.
Cruise Details
0
Flower farms in Sa Dec, Vietnam
from $2,539
EXPLORE

From the Mekong Delta to Siem Reap

Ho Chi Minh City to Siem Reap - 9 Day Itinerary aboard RV Indochine
  • Visit Ho Chi Minh landmarks
  • Cruise across Tonle Sap Lake
  • Explore Sa Dec’s Huynh Thuy Le
  • Visit Chau Doc temples
Starts / Ends
Ho Chi Minh City / Siem Reap
Activities
Urban Exploration
Activity Level
Variable
Embark on a 9-day Mekong River cruise aboard RV Indochine through Vietnam and Cambodia. Begin in Ho Chi Minh City and travel to Siem Reap, exploring temples, pagodas, markets, floating villages, and cultural landmarks along the way. Enjoy guided city tours, traditional crafts, and authentic cuisine.
Cruise Details
0
The Vinh Trang Temple in My Tho, Vietnam
from $2,539
EXPLORE

From Siem Reap to the Mekong Delta

Siem Reap to Ho Chi Minh City - 9 Day Itinerary aboard RV Indochine
  • Visit Koh Chen village
  • Explore Chau Doc’s pagodas
  • Visit Cai Be workshops
  • Discover Ho Chi Minh landmarks
Starts / Ends
Siem Reap / Ho Chi Minh City
Activity Level
Variable
Set sail on a 9-day Mekong River cruise through Cambodia and Vietnam aboard RV Indochine. Explore Siem Reap, Phnom Penh, Chau Doc, Sa Dec, Cai Be, My Tho, and Ho Chi Minh City. Visit temples, markets, pagodas, and local villages while experiencing authentic cultural traditions. Enjoy guided tours, regional flavors, and cultural performances.
Cruise Details
0
Sunset over the Mekong River
from $2,782
EXPLORE

Mekong River - Downstream - High water

Siem Reap to Saigon - 8 Day Itinerary aboard Jayavarman
  • Explore Tonle Lake by boat
  • Visit Kampong Laeang villages
  • Discover Phnom Penh’s history
  • Cross into Vietnam
  • Explore Gieng Island
Starts / Ends
Siem Reap / Ho Chi Minh City
Activities
Cooking Classes, Village Visits, Archaeological Site Visits
Activity Level
Variable
Sail aboard the Jayavarman on an 8-day Mekong River cruise from Siem Reap to Saigon. Explore Cambodia’s Tonle Lake, Phnom Penh’s historic sites, and Vietnam’s colorful Mekong Delta villages while discovering local crafts, culture, and daily river life.
Cruise Details
0
Sunset over the Mekong River
from $2,782
EXPLORE

Mekong River - Downstream - High water

Siem Reap to Saigon - 8 Day Itinerary aboard Jayavarman
  • Aboard a luxury riverboat in Mekong
  • See the floating market in Cai Be
  • Observed locals along the river
  • Visit Tan Chau floating fish farm
  • Visit Phnom Penh cultural sites
Starts / Ends
Siem Reap / Ho Chi Minh City
Activity Level
Variable
Explore the Mekong on this 8-day high-water Mekong River cruise from Siem Reap to Saigon. Get an inside look at the southern cultures of Vietnam and Cambodia as you travel across the mighty Mekong Delta. Stop in charming port towns and immerse yourself in the city's culture and history.
Cruise Details
0
Statues and intricate relief carvings inside Angkor Wat
from $4,125
EXPLORE

From the Angkor Temples to the Mekong Delta

Siem Reap to Ho Chi Minh City - 11 Day Itinerary aboard RV Indochine II
  • Visit Angkor Wat temples
  • Explore Phnom Penh landmarks
  • Visit Cu Chi tunnels in Saigon
  • Discover Koh Chen crafts
Starts / Ends
Siem Reap / Ho Chi Minh City
Activities
Local Market Visits, Land & Sea Exploration
Activity Level
Variable
Embark on an 11-day Mekong River cruise through Vietnam and Cambodia aboard RV Indochine II. Start in Siem Reap with Angkor temples, then sail across Tonle Sap Lake and explore Phnom Penh, Chau Doc, Sa Dec, Cai Be, and Ho Chi Minh City. Visit floating villages, historic landmarks, and cultural sites.
Cruise Details
0
Aerial view of Angkor Wat
from $3,675
EXPLORE

From the Mekong Delta to the Angkor Temples

Ho Chin Min City to Angkor - 11 Day Itinerary aboard RV Indochine
  • Visit Ho Chi Minh landmarks
  • Cu Chi tunnels tour
  • Explore Angkor Wat temples
  • Tour Sa Dec historic house
Starts / Ends
Ho Chi Minh City / Siem Reap
Activity Level
Variable
Experience an 11-day Mekong River cruise from Vietnam to Cambodia aboard RV Indochine. Explore Ho Chi Minh City landmarks, My Tho canals, Phnom Penh palaces, and Siem Reap’s Angkor temples. Visit bustling markets, floating villages, craft villages, and historic sites. Discover culture, tradition, and history on a unique river adventure through Southeast Asia.
Cruise Details
0
Floating Market in Cai Be
from $1,354
EXPLORE

Mekong River - Upstream

Saigon to Phnom Penh - 4 Day Itinerary aboard Jayavarman
  • Observed locals along the river
  • See the floating market in Cai Be
  • Explore the Gieng Island
  • Visit Phnom Penh cultural sites
Starts / Ends
Ho Chi Minh City / Phnom Penh
Activity Level
Variable
On this 4-day journey from Saigon to Phnom Penh, cruise the lower Mekong River in majestic style aboard the Jayavarman. Discover the culture and history of the various towns along the mighty Mekong while exploring the river.
Cruise Details
0
Beautiful architecture in Tonle Sap
from $4,800
EXPLORE

Mekong Discovery - Phnom Penh to Siem Reap

High water - 4 Day Itinerary aboard Aqua Mekong
  • Experience an indigenous tradition
  • Discover Koh Chen´s pottery
  • Explore the Moat Khla village
  • Kayak near the Tonle Sap Lake
Activity Level
Variable
Experience the colorful culture of Vietnam and Cambodia as you embark on this 4-day Mekong River Discovery Cruise from Phnom Penh to Siem Reap, and experience a richly-rewarding adventure by heading upriver in Cambodia and exploring the Tonle Sap Lake.
Cruise Details
0
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