Have questions? We're here.
What a view.

South America Tours & Cruises - 2026

Travel made your way
Talk with an expert
Build your ideal South America trip. Call 1.406.541.2677
Start Planning My Trip
Filter (901 Results)
  • Start Date
    OR, More specific start
  • Length
    to
  • Price
    to
  • Activity Levels
  • Experiences
  • Activities
  • Ships
  • Destinations
    • South America
Paradise Tropical Island - Bocas del Toro archipelago - Island Colon
from $24,990
EXPLORE

Pristine Islands of the Bahamas & the Panama Canal

Nassau - Panama City - 11 Day Itinerary aboard Scenic Eclipse
  • Explore Nassau’s colonial streets
  • Visit Staniel Cay’s beaches
  • Discover San Salvador’s coral reefs
  • Meet Cabo de La Vela’s Wayuu people
Starts / Ends
Nassau / Panama City
Activities
Village Visits
Activity Level
Variable
Join an 11-day cruise from Nassau to Panama City on the Scenic Eclipse, exploring the Bahamas' clear waters and vibrant island cultures. Experience highlights like Pig Beach and the Panama Canal, blending leisure with cultural discovery.
Cruise Details
0
See the beautiful wildlife in Antarctica.
from $21,080
EXPLORE

Ultimate Antarctic Adventure

Roundtrip Ushuaia - 20 Day Itinerary aboard RMS St. Helena
  • Cross the Drake Passage
  • Visit Gentoo penguin colony
  • Cruise scenic Beagle Channel
  • Explore South Shetland Islands
Starts / Ends
Port of Ushuaia / Port of Ushuaia
Activities
Hiking, Camping, Kayaking, Wildlife Viewing, Whale Watching, Photography Seminars
Activity Level
Variable
This 20-day Ultimate Antarctic Adventure aboard RMS St. Helena begins in Ushuaia, sailing through the Beagle Channel and crossing the Drake Passage to reach the South Shetland Islands and Antarctic Peninsula. Explore via ship aboard Icebird yacht, adventure into remote bays and narrow channels inaccessible to larger vessels
Cruise Details
0
Giant lily pads on the Amazon River
from $3,856
EXPLORE

Amazon Journey via Ucayali River- Low Water Season

Iquitos to Nauta - 4 Day Itinerary aboard Zafiro
  • Visit the Mirrored Forest
  • See pink and grey dolphins play
  • Explore the black water streams
Starts / Ends
Nauta / Nauta
Activity Level
Variable
Explore the Amazon, Ucayali, and Pacaya Rivers on their way deep into the Pacaya Samiria Reserve, one of Peru´s largest national parks. Go piranha fishing, trek into the dense jungle in search of Amazon wildlife and birds, take a night safari and guided trips, visit local villages, and learn about wildlife preservation efforts in Peru’s Amazonia.
Cruise Details
0
Sunset over Cartagena, Colombia
from $2,005
EXPLORE

Cartagena Adventure

5 Day Itinerary
  • Visit Cartagena's historical sites
  • Prepare dishes with a local chef
  • Taste the best liquor in Colombia
  • Visit the Bazurto market
  • Swim in Tierra Bomba
  • Learn about Palenque de San Basilio
Starts / Ends
Cartagena / Cartagena
Activities
Wine Tasting, Cooking Classes
Activity Level
Easy Active
Experience Cartagena’s vibrant culture with rum and chocolate tasting, a market tour and cooking class, a historical visit to San Basilio de Palenque, and a relaxing day at Blue Apple Beach. This unique trip delves into the heart of Colombia’s rich heritage and stunning landscapes.
Tour Details
0
Cathedral
from $365
EXPLORE

Explore Cuenca

4 Day Itinerary
Activities
Urban Exploration
Activity Level
Relaxed
Fly south to the delightful city of Cuenca. Considered the most colonial city in all the Americas, red clay rooftops stretch throughout the city and baroque churches seem to stand on every corner. This time in Cuenca is yours to explore however you like. Chose from several short excursions to add to your stay in this charming town.
Tour Details
0
Enjoy a blissful snorkeling trip.
from $6,195
UP TO 15%
EXPLORE

Western Islands

7 Day Itinerary aboard Treasure of Galapagos
  • Hike Dragon Hill on Santa Cruz
  • Appreciate Isabela's wetlands
  • Observe diverse wildlife
  • Snorkel, swim & hike the Galapagos
Starts / Ends
Baltra / Baltra
Activity Level
Variable
This 7-day Western Islands cruise on the ship, Treasure of the Galapagos, explores Rabida, Santa Cruz, Fernadina, and more! Experience the fascinating western islands and understand how volcanic activity and isolation shaped the landscape. Encounter diverse wildlife, birdlife, and marinelife on your memorable vacation.
Cruise Details
0
Hiking in Ecuador
from $1,723
EXPLORE

Cotopaxi Trekking

7 Day Itinerary
  • Take in the volcanic mountain views
  • Hike through native Andean forest
  • Visit an Andean Cowboy community
  • Explore Inca sites
Activities
Hacienda Visits
Activity Level
Challenging
Experience Cotopaxi National Park in a unique way as you trek the ancient roads of the Inca. The full day hikes will take you past Inca sites and offer stunning views of Cotopaxi volcano. During your five days of hiking you'll split your evenings between campsites and classic Haciendas.
Tour Details
0
Iceberg Flow during Trip to the Antarctic Peninsula
from $38,140
EXPLORE

The Great Austral Loop

Ushuaia Roundtrip - 19 Day Itinerary aboard Le Lyrial
  • Observe New Island penguins
  • Visit South Georgia’s Gold Harbor
  • Observe whales, seals, and seabirds
  • Explore Salisbury Plain
Starts / Ends
Buenos Aires / Buenos Aires
Activity Level
Variable
Embark on a 19-day cruise from Buenos and Ushuaia to Antarctica aboard Le Lyrial. Explore the Falkland Islands, South Georgia, and the Antarctic Peninsula. Experience Zodiac landings, wildlife encounters, glaciers, and historic polar routes.
Cruise Details
0
A male frigatebird rests in the trees of the Galapagos
from $84,720
EXPLORE

Private Charter - Northeast Islands I

8 Day Itinerary aboard Archipel I
  • Visit the spectacular Sullivan Bay
  • Swim and snorkel with sea lions
  • Meet Galapagos giant turtles
  • Observe mating blue-footed boobies
Starts / Ends
Baltra / San Cristobal Airport
Activities
Snorkeling
Activity Level
Variable
This 8-day private Northeast Islands cruise onboard the Archipel I combines the sea lion colonies of Mosquera Islet and the exclusive Genovesa with the stunning volcanic islands of Bartolome and the Charles Darwin Research Station. Explore Española, the archipelago's southernmost point, and view blue-footed boobies on San Cristobal's Witch Hill.
Cruise Details
0
Panama's turquoise waters
from $4,450
EXPLORE

Panama to Antigua

15 Day Itinerary aboard Royal Clipper
  • Explore Balboa’s colonial charm
  • Transit Panama’s iconic canal
  • Discover San Blas culture
  • Enjoy Aruba’s clear waters
Starts / Ends
Balboa / St. John's
Activity Level
Variable
Set sail on a 15-day Royal Clipper cruise from Balboa, Panama, featuring a full Panama Canal transit and visits to the San Blas Islands, Cartagena, and the Caribbean gems of Aruba, Curacao, and Bonaire. Experience lush Grenada and volcanic St. Lucia, and finish your journey in Antigua, all while enjoying elegant sailing and stunning island views.
Cruise Details
0
The vivid colors of the San Blas Islands
from $4,330
EXPLORE

Barbados to Panama

Bridgetown - Balboa - 15 Day Itinerary aboard Star Clipper
  • Explore Bridgetown’s heritage
  • Discover St. George’s coastal views
  • Admire Kralendijk’s marine life
  • Wander Willemstad’s streets
Starts / Ends
Bridgetown / Balboa
Activities
Archaeological Site Visits, Small Ship Sailing, Local Market Visits
Activity Level
Variable
Set sail on a 15-day cruise with Star Clipper from Bridgetown, Barbados, exploring the Caribbean’s rich culture and history, ending in Balboa, Panama. Visit stunning destinations like Tobago Cays, Grenada, and the San Blas Islands, and experience the Panama Canal.
Cruise Details
0
Tree frog spotted in the Amazon
from $4,178
EXPLORE

Amazon Journey via Marañon River- Low Water Season

Nauta to Nauta - 5 Day Itinerary aboard Zafiro
  • Visit the birth place of the Amazon
  • Kayak and swim in the Amazon River
  • Meet and visit with locals
Starts / Ends
Iquitos / Nauta
Activities
Rainforest Exploration, Fishing
Activity Level
Variable
Embark on a 5-day cruise aboard Zafiro exploring the wonderful Amazon and its tributaries towards the Sapote River, a buffered zone of the Pacaya-Samiria National Reserve. Naturalist guides use their eagle eyes to help you spot extraordinary wildlife and act as interpreters so that you may learn from Amazonian communities.
Cruise Details
0
637-648 of 901 Results

Real experience. Honest advice.

Talk with an expert trip planner 1.800.344.6118

Plan My Trip
Sandra Fernandez employee profile
Sandra F.
Peruvian weavers
South America

Chat South America with a specialist

Our team is waiting and ready to talk with you about your next adventure. So go ahead and book an appointment with one of our specialized trip planners.

Let's Chat
1.800.344.6118

Where is your next adventure?

Contact Chat Call
More Reasons

Why Travel With Adventure Life

All News

Featured In

How it Works

Connect

No cost, no commitment. Talk with our experts about your dream trip.

Plan

Share your travel style—we match you with the right itinerary or create one just for you.

Book

Lock in knowing every detail is handled and you’re fully supported.

Travel

Enjoy a seamless journey—and unlock 5% off your next adventure.

South America Travel Guide

Favorite South America South America All Trips

Top South America Travel Destinations

South America Trips by Departure Date

Top Experiences in South America

South America Trips by Duration

South America Trips by Activity