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Snake River Cruises

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Most Some of our Snake River cruises begin in Portland, embarking on the Columbia River. The Snake River begins on the Idaho and Wyoming border, and later downriver forms the border between Oregon and Idaho. It ends near the border of Washington and Oregon, where it joins the Columbia River and goes all the way to the Pacific Ocean.  Eventually, cruise upriver to the town of Richland, where your boat will continue east onto the Snake River. Here, most cruises make it all the way to Washington and Montana. 
 
Many travelers choose a snake river cruise to experience dramatic canyon landscapes, wildlife viewing, and historic towns. Our selection of snake river cruises also pairs well with itineraries along the Columbia River, offering the perfect blend of nature and culture. Consider a scenic Columbia River cruise Portland to Astoria to explore charming riverside towns and coastal beauty. For shorter day trips, our Columbia River boat tours are a great way to see waterfalls, lighthouses, and wine country. If you’re wondering about pricing, we provide transparent details on Columbia River cruises so you can plan with confidence with our helpful Trip Planners. Contact them now!

8 Best Snake River Cruises for 2026-2027

US River Cruises

More United States & Columbia Cruises

Visit historic St. Louis
from $6,499
EXPLORE

Heartland of America

Missouri to Minnesota - 8 Day Itinerary aboard Viking Mississippi
  • Walk Mark Twain’s Hannibal
  • Explore John Deere innovations
  • Explore historic Burlington charm
  • Explore ancient mound builders
Starts / Ends
St. Louis / St. Paul
Activities
Hiking
Activity Level
Variable
Discover America’s heartland on an 8-day Viking Mississippi cruise from Alton to Red Wing, exploring St. Louis, Hannibal, Burlington, the Quad Cities, Dubuque, and La Crosse. From Mark Twain’s hometown to the Mississippi River Museum, each stop offers a direct look into the nation’s past.
Cruise Details
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Explore beautiful Nashville
from $5,499
EXPLORE

Nashville, Memphis & the Cumberland

Memphis to Nashville - 8 Day Itinerary aboard Viking Mississippi
  • Discover Memphis blues roots
  • See Paducah murals
  • Walk historic Clarksville streets
  • Cruise Tennessee River scenery
Starts / Ends
Memphis / Nashville
Activity Level
Variable
Take an 8-day Viking Mississippi cruise through Memphis, Cape Girardeau, Paducah, Clarksville, and Nashville. Visit key cultural and historical sites, from music landmarks to Civil War history and regional museums.
Cruise Details
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Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $5,635
Savings
EXPLORE

Upper Mississippi River

St. Paul, MN - St. Louis, MO - 9 Day Itinerary aboard American Serenade
  • Tour historic Summit Avenue
  • Explore Dubuque River Museum
  • Experience John Deere Pavilion
  • Visit Mark Twain’s boyhood home
Starts / Ends
St. Paul / St. Louis
Activities
Biking
Activity Level
Variable
Set sail for 9 days aboard American Serenade from St. Paul to St. Louis. Walk through historic Summit Avenue, admire La Crosse from Grandad’s Bluff, explore Dubuque’s River Museum, and discover Mark Twain’s legacy in Hannibal. Experience curated onboard programs, live music, and the beauty of the Upper Mississippi’s diverse wildlife.
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St. Louis, Missouri skyline and the famous Gateway Arch
from $12,620
Savings
EXPLORE

Grand Heartland River Cruise

St. Paul, MN - New Orleans, LA - 16 Day Itinerary aboard American Melody
  • Explore La Crosse's river
  • Discover Dubuque's river heritage
  • Experience Memphis blues heritage
  • Explore Vicksburg Civil War Sites
Starts / Ends
St. Paul / New Orleans
Activities
Wine Tasting
Activity Level
Variable
Sail the Mississippi River from St. Paul to New Orleans on a 16-day cruise aboard American Melody. Visit La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, Natchez, and Baton Rouge while exploring river history, Native heritage, Civil War sites, music, architecture, museums, agriculture, and regional culture.
Cruise Details
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Visit historic and hilly Pittsburgh
from $5,815
Savings
EXPLORE

Ohio River Cruise

Pittsburgh to Louisville - 10 Day Itinerary aboard American Symphony
  • Learn Pittsburgh steel city history
  • See Wheeling Victorian architecture
  • Cruise scenic Ohio River
  • Visit Louisville Slugger Museum
Starts / Ends
Pittsburgh / Louisville
Activity Level
Variable
Set sail on a 10-day river cruise from Pittsburgh to Louisville aboard American Symphony, tracing the Ohio River through Wheeling, Marietta, Cincinnati and Madison. See steel-era history, ancient earthworks, and bourbon country.
Cruise Details
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Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $12,620
Savings
EXPLORE

Grand Heartland Cruise

St. Paul to New Orleans - 16 Day Itinerary aboard American Serenade
  • Cruise Mississippi River scenery
  • Discover Davenport museums
  • Visit Gateway Arch landmark
  • Tour Vicksburg battlefields
Starts / Ends
St. Paul / New Orleans
Activity Level
Variable
Cruise the Mississippi River on a 16-day voyage aboard American Serenade. Visit La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Tunica, Vicksburg, Natchez, and Baton Rouge while exploring museums, riverfronts, historic landmarks, Civil War sites, and music destinations. Enjoy scenic cruising through the Upper and Lower Mississippi.
Cruise Details
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View the iconic arch when you visit St. Louis, gateway to the west
from $9,920
Savings
EXPLORE

Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody
  • Explore historic Marietta, Ohio
  • Explore Maysville’s Railroad
  • Visit Louisville’s Churchill Downs
  • Tour Paducah’s wall murals
Starts / Ends
Pittsburgh / St. Louis
Activity Level
Variable
Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.
Cruise Details
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Explore Nashville
from $11,270
Savings
EXPLORE

Mississippi and Cumberland Rivers Cruise

New Orleans to Nashville - 16 Day Itinerary aboard American Symphony
  • Cruise Mississippi and Cumberland
  • Explore Vicksburg's battlefields
  • Trace jazz, blues & country roots
  • Wander at the Oak Alley Plantation
Starts / Ends
New Orleans / Nashville
Activities
Urban Exploration, Village Visits, Wildlife Viewing, Archaeological Site Visits, Cooking Classes, Local Market Visits
Activity Level
Variable
Embark on a 16-day cruise linking two rivers, the Mississippi and Cumberland, between New Orleans and Nashville aboard American Symphony. Visit Civil War battlefields, antebellum estates, and the birthplaces of jazz, blues, and country music.
Cruise Details
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Visit historic and hilly Pittsburgh
from $9,920
Savings
EXPLORE

Grand Ohio River Cruise

St. Louis to Pittsburgh - 16 Day Itinerary aboard American Melody
  • Explore St. Louis history
  • Discover Paducah river heritage
  • Explore Louisville traditions
  • Discover Cincinnati heritage
Starts / Ends
St. Louis / Pittsburgh
Activity Level
Variable
Explore a 16-day Mississippi and Ohio River cruise from St. Louis to Pittsburgh aboard American Melody. Visit Paducah, Henderson, Evansville, Louisville, Madison, Cincinnati, Maysville, and Marietta, with time for museums, historic districts, Underground Railroad sites, regional art, river heritage, and American history. Discover local history.
Cruise Details
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Enjoy the colorful architecture of New Orleans
from $5,275
Savings
EXPLORE

Lower Mississippi River Cruise

New Orleans - Memphis - 9 Day Itinerary aboard American Melody
  • Explore New Orleans lively culture
  • Discover Oak Alley with landscapes
  • Discover Baton Rouge
  • Visit Graceland Memphis
Starts / Ends
New Orleans / Memphis
Activity Level
Variable
Embark on a 9-day cruise from New Orleans to Memphis aboard American Melody, exploring Southern culture and history with local guides. Enjoy enriching excursions, gourmet meals, daily cocktails, and captivating shows at historic sites like Vicksburg and Natchez.
Cruise Details
0
View monuments from the Civil War in Mississippi
from $9,850
EXPLORE

Mississippi & Tennessee Rivers Cruise

Huntsville - New Orleans - 16 Day Itinerary aboard American Heritage
  • Explore Huntsville Space History
  • Discover Florence Music Heritage
  • Explore Vicksburg Civil War Sites
  • Discover New Orleans Culture
Starts / Ends
Florence / New Orleans
Activity Level
Variable
Explore a 16-day river cruise from Huntsville to New Orleans aboard American Heritage, following the Tennessee and Mississippi Rivers through Florence, Savannah, Paducah, Memphis, Vicksburg, Natchez, St. Francisville, Baton Rouge and Oak Alley, with historic sites, museums, music, Civil War history and Southern culture and historic cultural sites.
Cruise Details
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Visit Louisiana's capital city of Baton Rouge
from $8,670
Savings
EXPLORE

Mississippi & Tennessee Rivers Cruise

New Orleans to Huntsville - 16 Day Itinerary aboard American Heritage
  • Explore New Orleans History
  • Visit Oak Alley Estate
  • Explore Vicksburg Civil War
  • Explore Memphis Music Heritage
Starts / Ends
New Orleans / Florence
Activity Level
Variable
Explore New Orleans to Huntsville on a 16-day Mississippi River cruise aboard American Heritage. Visit historic estates, Civil War sites, music landmarks, museums, arts districts, and river towns while following the Mississippi and Tennessee rivers through Louisiana, Mississippi, Tennessee, Kentucky, and Alabama. Experience local traditions.
Cruise Details
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