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Visit historic and hilly Pittsburgh

Grand Ohio River Cruise

St. Louis to Pittsburgh - Example 16 Day Cruise aboard American Melody
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Travel from St. Louis to Pittsburgh on a 16-day Mississippi and Ohio River cruise aboard American Melody. Explore St. Louis and the Gateway Arch, then visit Paducah’s National Quilt Museum and Civil War sites, Henderson’s Audubon heritage, Evansville’s wartime history, Louisville’s Kentucky Derby and bourbon traditions, Madison’s historic architecture, and Cincinnati’s Underground Railroad and art museums. Continue to Maysville and Marietta for frontier, railroad, river, and regional history before reaching Pittsburgh. Along the way, cruise the Mississippi and Ohio rivers, join onboard activities, and enjoy time on deck. In Pittsburgh, visit the Andy Warhol Museum and Heinz History Center. Discover historic architecture, river communities, and sites tied to industry, transportation, and the Underground Railroad.
View the iconic arch when you visit St. Louis, gateway to the westBridge and city lights in Ohio RiverSt. Louis' iconic arch at nightkentucky louisvilleVisit historic Cincinnati, OhioEnjoy scenic lake in Louisville, KentuckyCruise the rivers of KentuckyVisit historic and hilly Pittsburgh
Highlights
  • Explore St. Louis museums and landmarks tied to westward expansion
  • Discover Paducah murals, museums, and Civil War history along riverfront
  • Explore Louisville bourbon, Derby, baseball, and riverfront history
  • Discover Cincinnati art, architecture, and Underground Railroad history
Places Visited
Activity Level: Variable
Activity options vary depending on destination and operator. Activity level is determined by the range and intensity of activities you choose to participate in. Discuss with your Trip Planner which options are best for you.
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Full Itinerary

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Day 1: St. Louis, MO

Explore St. Louis and its riverfront, home to the Gateway Arch, a landmark associated with the city’s role in U.S. westward expansion.

Visit the National Great Rivers Museum to learn about the Mississippi River, its history, communities, and ecosystems. Explore the Missouri History Museum in Forest Park, which traces the region’s history and includes exhibits connected to the 1904 World’s Fair.

See the Cathedral Basilica and its mosaic interior, then visit the Gateway Arch and its underground museum to learn more about the history of St. Louis and the expansion of the United States westward.

Day 2: Embark | Cruising the Mississippi River

Cruise the Mississippi River toward the Ohio River, with time to join onboard activities such as trivia in the lounge or shuffleboard on the top deck. Relax on your private balcony and watch the countryside and river views along the way. Use cruising days to take part in activities or enjoy quiet time onboard.

Day 3: Paducah, KY

Just upstream from your ship's mooring, the Tennessee River flows into the mighty Ohio River, painting a stunning portrait. Nearby, the confluence with the Cumberland River and the iconic Mississippi adds to the riverine symphony, creating a dynamic crossroads at the heart of Paducah's maritime legacy.

As you stroll along the bustling riverfront landing, you'll encounter a visual feast: over 50 intricate murals that vividly depict Paducah's dynamic history. These murals chronicle the town's pivotal moments, from its strategic significance during the Civil War to its emergence as a bustling river port that shaped the destiny of a nation.

For an artistic delight, visit the National Quilt Museum, located a mere block from the riverfront. Here, you'll be awestruck by an extraordinary collection of quilts, each an amazement in its own right and a testament to the skill of its artisans.

Paducah Local Loop - Complimentary Excursion
Experience Paducah at your leisure with convenient Cruise Coach service throughout the city. Stops include:
The National Quilt Museum - Discover one of Paducah’s most celebrated cultural attractions. Admire striking works by renowned quilters who push the boundaries of fiber art through imaginative designs, techniques, and contemporary approaches. 
Lowertown Arts District & Neighborhood - Wander through this charming 25-block neighborhood, listed on the National Register of Historic Places and known for its beautifully preserved architecture. Look for the neighborhood directory at the iconic Texaco Station to help guide your exploration.  
Civil War Museum & Tilghman House - Step inside this remarkable 1852 Greek Revival home and hear the fascinating stories of Paducah’s role during the Civil War. Learn about the people and events that reveal the city’s strategic importance and significant influence during this pivotal period in America.
Paducah Railroad Museum - Travel back to the golden age of American railroading at this engaging, interactive museum. View railroad equipment, artifacts, memorabilia, and hands-on exhibits that capture the romance and excitement of the railroads and their lasting impact on Paducah and the region.
River Discovery Center - Explore Paducah’s deep connection to the rivers that have shaped its history and identity. Interactive, water-filled exhibits bring the region’s maritime heritage to life, including a working model of a lock and dam that demonstrates the fascinating engineering behind river navigation.
Activity Level: Low | ADA Accessible: Yes

Day 4: Day of Cruising

Today, be on the lookout for the diverse array of wildlife that thrives in this region's rich ecosystem. Spot white-tailed deer gracefully bounding through the meadows, while cunning red foxes dart among the trees. Don't forget to watch for the adorable cotton-tail rabbits that scamper across the riverbanks, adding a touch of charm to your scenic journey. With every passing moment, the Ohio River reveals its vibrant and captivating tapestry of life, ensuring an unforgettable cruise experience filled with energy and excitement.

Day 5: Henderson, KY | Evansville, IN

Henderson, a relaxed river town, is imbued with stories and a deep sense of community. This town also served as the creative sanctuary for naturalist and artist John James Audubon in the early 1800s, where he crafted many of his stunning "Birds of America" masterpieces.

Just down the river, discover Evansville, a city that harmoniously blends contemporary and historical architecture. As the site of Bally's Evansville, Indiana's inaugural casino, the city offers a unique vibrancy alongside tranquil cultural sites like Mesker Park Zoo and Botanic Garden, one of the state's oldest and largest zoos. Experience the local culture with visits to the city's diverse museums and enjoy leisurely shopping and strolls through the enchanting streets of this scenic waterfront town. Each corner of Evansville offers a delightful mix of past and present, inviting visitors to explore and enjoy its unique charm.

Audubon Museum and Nature Center - Complimentary Excursion
The Audubon Museum and Nature Center interprets the life of John James Audubon through his art and personal memorabilia framed within a timeline of world events. Join a park naturalist on a guided tour before enjoying some free time to explore the Museum’s three galleries and the Center’s wildlife observation room, theater, and Discovery & Learning Center on your own.
Activity Level: Low | ADA Accessible: No

The Evansville Wartime Museum Exploration – Complimentary Excursion
This unique museum celebrates the service of the Evansville region's armed forces, focusing on the manufacturing contributions made during World War II by the region's hometown heroes. Be treated to an exclusive exploration of the Main Hall and four galleries. The Home Front Gallery displays exhibits on the wartime munitions and personal military memorabilia, including uniforms, weapons, and honors. Also featured is the Evansville Canteen - having served the troops passing through on their way to war, an exhibit honoring the sacrifices made by nurses in the war, as well as period automobiles, and military equipment, such as a landing craft from the LST 325, an Evansville-built P-47 Thunderbolt fighter plane, and a 1943 M4A4 Sherman Tank, to name a few.
Activity Level: Low | ADA ACCESSIBLE: Yes

Day 6: Day of Cruising

As you cruise along the grand Ohio River, experience the serene beauty of America's heartland. Witness the gentle sweep of greenery along the banks, interspersed with quaint towns that can be seen from the top deck. Partake in a variety of onboard activities designed to enrich your journey, from historical presentations to lively discussions, each adding depth to the stunning vistas that unfold before you. Let the rhythm of the river carry you through landscapes steeped in history, offering a peaceful yet engaging backdrop to your exploration. Each mile traveled is a new chapter in the unfolding story of the Ohio River, inviting you to witness its quiet waves and enduring charm.

Day 7: Louisville, KY

Louisville, a vibrant waterfront town, climbs gracefully up the hillside, its spirit etched deep into the fabric of American history. This city first flourished as a crucial portage around the perilous Falls of the Ohio, now tamed behind the expansive sweep of the Ohio River’s Markland Dam.

Step into the world of horseracing at the legendary Churchill Downs, home to the Kentucky Derby—the oldest continuously held horse race in the nation. For a slice of Americana, visit the Louisville Slugger Museum & Factory, where the iconic baseball bats are crafted.

No visit to Louisville would be complete without experiencing its famed bourbon heritage. Tour a local distillery, where the rich aroma of aging spirits fills the air. Sip the refined flavors of Kentucky bourbons, each taste telling a story of craftsmanship and the history of Bluegrass country.

Kentucky Derby Experience - Complimentary Excursion
Get a behind-the-scenes look at the world-famous Churchill Downs Racetrack. Walk through a portion of the grandstands where thousands of people roar with excitement on Derby Day. Your guide leads you to the rail of the legendary dirt track where every Derby winner has raced, from Aristides to Secretariat and more. Have your camera ready for pictures of the historic track. Hear stories of the early days of the Kentucky Derby through its transformation into the event it is today. Enjoy a viewing of the epic film, The Greatest Race, a 360-degree, 18-minute media experience that makes your heart race and your emotions soar. Be treated to Mint Juleps and Derby Pie Bites as you listen to a special presentation by an actual Kentucky Derby Jockey who can answer any questions you may have about this iconic event.
Activity Level: Low | ADA Accessible: Yes

Day 8: Madison, IN

quaint town located on the banks of the Ohio River, Madison is one of the oldest and most charming cities in the state, known for its well-preserved 19th-century architecture. The historic district, listed on the National Register of Historic Places, features over 130 preserved buildings that showcase a mix of Greek Revival, Victorian, and Federal styles.

With several local sites linked to the abolitionist movement, Madison’s rich history includes a significant role in the Underground Railroad. The town also celebrates its heritage during the Madison Regatta, one of the oldest hydroplane races in the U.S.

Considered an outdoor museum of architecture, stroll through the vibrant downtown which abounds with boutique shops, art galleries, and restaurants. Take time to admire the town’s natural beauty, with scenic views of the river and surrounding hills serving as a picturesque backdrop.

Madison Local Loop – Complimentary Excursion
Take the opportunity to explore history, shopping, and the culture of USA Today's Best Small Town in the Midwest. Don't miss the opportunity to walk on Main Street to find unexpected historical buildings, galleries, and boutiques. With more than 133 blocks of outstanding architecture, Madison’s downtown business district is one of the country’s largest National Historic Landmark Districts. Madison’s founders brought with them their own history, which is displayed in the architecture of the homes and buildings that make up this historic gem. Travel America says, “Madison is an outdoor museum of architecture.”
Activity Level: Low | ADA Accessible: Yes

Day 9: Cincinnati, OH

The striking bridges spanning the Ohio River create a magnificent entrance to Cincinnati, affectionately known as the “Queen City.” Originally a key shipbuilding and shipping metropolis, it has transformed into a dynamic cultural hub. Here, you can explore top-notch sports teams, the delightful Cincinnati Zoo and Botanical Garden, numerous theaters, and a range of museums, including the renowned National Underground Railroad Freedom Center, a Smithsonian Affiliate Museum.

Take a leisurely walk through the city streets, taking in the diverse architectural styles. Notable spots include the expansive Krohn Conservatory and the majestic St. Mary’s Cathedral Basilica. For a dish just as unique as the city itself try Cincinnati Skyline Chili or enjoy a scoop of ice cream from Graeter’s, a cherished establishment since 1868.

National Underground Railroad Freedom Center - Complimentary Excursion
The National Underground Railroad Freedom Center celebrates the brave men and women who came together to create a secret network through which the enslaved could escape to freedom. Their examples of courage, cooperation, and perseverance are relevant to this day, as you continue to deal with contemporary issues of equality and diversity. 
Activity Level: Low | ADA Accessible: Yes

Cincinnati Art Museum - Complimentary Excursion
Explore the Cincinnati Art Museum, located in scenic Eden Park. Featured is a diverse, comprehensive art collection of more than 67,000 works spanning 6,000 years. In addition to displaying its own encyclopedic collection, the museum also hosts a variety national and international traveling exhibitions each year.
Activity Level: Low | ADA Accessible: Yes

Cincinnati City Experience - Complimentary Excursion
Explore both sides of the river on this fantastic, all-encompassing excursion. Begin in the heart of the city at Fountain Square. Along your journey, view the Contemporary Arts Center, Procter and Gamble’s International Headquarters, and the Taft Museum in beautiful Lytle Park. Learn about Cincinnati’s most well-known landmarks including: Union Terminal, Music Hall, Washington Park, Smale Riverfront Park, Bicentennial Commons, the new TQL Stadium, and the Paul Brown Stadium and Great American Ball Park – home of the Bengals and Reds.

Enjoy the old-world charm of Mount Adams with its “shot-gun” row homes and charming district of shops and restaurants. View picturesque Eden Park, home to the Cincinnati Art Museum, Playhouse in the Park, and Krohn Conservatory. 

Cross the Ohio River to Kentucky’s historic Riverside Drive with its antebellum homes. Explore the entertainment district at Newport on the Levee and the World Peace Bell – the largest free-swinging bell in the world. While in Kentucky, you can enjoy a breathtaking view of the Cincinnati skyline. 
Activity Level: Low | ADA Accessible: Yes

Day 10: Day of Cruising

Today is all about carefree enjoyment. Make the day your own and engage in fascinating presentations and fun-filled onboard activities. Enjoy gourmet meals and signature cocktails, and don’t miss freshly baked cookies at 3pm. Relax in the expansive lounges or feel the soft breeze on the sun deck, a prime spot for getting lost in a good book or engaging in conversations with new friends. It’s your day to simply relax and have a great time.

Day 11: Maysville, KY

From your vantage point on the ship's deck, take a moment to appreciate the scenic charm of Maysville, tucked into the hillside. This town marks a historic location, where early flatboat merchants, after trading down the Mississippi to the Gulf, journeyed back via the Natchez Trace Pathway to reconnect with the Ohio River.

Explore the town's pivotal role in the Underground Railroad, where daring escapes across the river were orchestrated. Uncover the story of Harriet Beecher Stowe’s visit, which profoundly influenced her writing of the classic story Uncle Tom’s Cabin. You'll also enjoy tales of notable locals such as the bold explorer Simon Kenton and the beloved singer and actress Rosemary Clooney.

Old Washington Exploration - Complimentary Excursion
Step back in time while you tour the historic town of Old Washington. Starting at the 1790s Visitor Center, your costumed guide leads you through this historic Kentucky village, taking you along flagstone sidewalks graced with authentic frontier log cabins and early 19th-century homes. 
Activity Level: High | ADA Accessible: Yes

Discover Maysville - Complimentary Excursion
Discover small town charm during a narrated exploration of historic Maysville. Begin at the Kentucky Gateway Museum Center, which brings the stories of explorers, artists, and movie stars to life through award-winning dioramas and a collection of artifacts. 

Visit The Russell Theater, opened in 1930 by Colonel J. Barbour Russell, a flamboyant, well-known Maysville businessman who made his early fortune in the grocery business. The structure is constructed entirely of steel, concrete, brick, and terra cotta in Spanish Colonial style with a Moorish influence. This Theater is atmospheric, and one of only two in Kentucky.

In 1953, Rosemary Clooney, a Maysville native, premiered her movie, The Stars Are Singing. Today, the lobby is dedicated to memorabilia of that night and other items of interest to Clooney fans. After nearly being torn down, The Russell Theater was saved by volunteers who donated countless hours restoring and preserving this heart of Maysville, which is listed in individually on the National Register of Historic Places.
Activity Level: Low | ADA Accessible: Yes

Day 12: Day of Cruising

After a full day in Maysville, use this day on the river to recharge for more exploration ahead. The crew has planned a variety of onboard activities for you to participate in. With onboard experts providing lectures and a wide-open sun deck, use today to do whatever it is you want.

Don’t miss cocktail hour to catch up with fellow travelers and get ready for a night of lively entertainment. Enjoy the ever-changing landscapes that unfold from the deck—scenes reminiscent of those witnessed by the earliest navigators of these waters. Each twist and turn of the river bring a fresh, breathtaking scene, offering a silent narrative of nature and history intertwined along these significant waterways.

Day 13: Marietta, OH

This quaint town sits at the meeting place of the Muskingum River and the Ohio River, home to five National Register Historic Districts featuring buildings that have stood since its founding in 1788. Stroll through the earliest settlement in the Northwest Territory, on the north side of the Ohio River. Listen to the stirring stories of significant events that unfolded here, as detailed in The Pioneers, the recent book by Pulitzer Prize-winning historian David McCullough.

The Castle Historic House Museum - Complimentary Excursion
Explore this beautifully preserved, 1855 Gothic-Revival house which is on the National Register of Historic Places. The Castle was once home to some of Marietta's most prominent citizens and the site of many prestigious functions. Hear fascinating stories about its history and learn about of one of the oldest regions in the Northwest Territory.
Activity Level: Medium | ADA ACCESSIBLE: Yes

Marietta Local Loop - Complimentary Excursion
Explore the captivating museums of Marietta at your leisure with the convenient shuttle, making stops at:
Campus Martius and Ohio River Museum - Explore America’s migration west, its earliest native inhabitants, and Marietta’s pioneers. Discover the golden age of the steamboat and learn more about the ecology of the Ohio River system. Outside the museum, visitors can take an escorted exploration of the WP SNYDER JR – the last intact, steam-powered “pool-type” stern-wheeled towboat in the United States.

Children’s Toy & Doll Museum - Get a glimpse into what entertained and educated children in the late 19th and early 20th centuries. Explore nine rooms, displaying antique and vintage doll collections, including Kewpie dolls, Barbie dolls and GI Joe model dolls, miniature houses, as well as larger models of fairy tale homes such as the Ole’ Woman in the Shoe model and a Hansel and Gretel Gingerbread Doll House. 
Activity Level: Low | ADA Accessible: Yes

Day 14: Day of Cruising

Delight in a relaxing day cruising through the heart of the Appalachian foothills, revealing lush landscapes and picturesque riverfront towns. Winding through charming valleys, dense forests, tranquil lakes, and rolling hills that paint a picture of nature’s unspoiled beauty. As you approach Pittsburgh, the city’s iconic bridges and stunning skyline become clear, nestled between the Allegheny and Monongahela rivers. The progression from rural tranquility to urban vibrancy is breathtaking, with the city’s steel heritage blending seamlessly with modern architecture, offering a perfect contrast of old and new.

Day 15: Pittsburgh, PA

Pittsburgh, once the beating heart of manufacturing, played a pivotal role in shaping the corridors of national and international commerce along the Ohio River. This industrious city flourished in the 18th and 19th centuries, its wealth evident in the grand architecture and the spirit of innovation that still permeates its streets. Upon your arrival, settle into your hotel, then step out to wander the city at your own pace.

Discover the legacies of American titans like Heinz and Carnegie, who planted their roots in this dynamic city. As you meander through the city, you'll feel the echoes of a rich past intermingling with the vibrant, forward-looking energy that defines Pittsburgh today.

The Andy Warhol Museum - Complimentary Excursion
Visit the largest museum in North America dedicated to a single artist. The Andy Warhol Museum holds an extensive permanent collection of art and archives from this Pittsburgh-born pop art icon. Explore the museum’s many galleries, which feature his paintings, photographs, unique prints, and sculptures, as well as Warhol films and videotaped works. A must-see for any art aficionado.
Please Note: This excursion is only available on cruises ending in Pittsburgh.

Senator John Heinz History Center - Complimentary Excursion
Named after Republican Politician Senator John Heinz, this interactive museum is full of six floors worth of Western Pennsylvania History, covering the past 250 years. Exhibits include the life of Senator John Heinz, the history of Pittsburgh, professional sports memorabilia, and much more.

Please Note: This excursion is only available on cruises ending in Pittsburgh.
Activity Level: Medium | ADA Accessible: Yes

Pittsburgh City Experience - Complimentary Excursion
Enjoy your locally guided experience exploring Pittsburgh, PA, ranked one of the most livable cities in America. Located at the confluence of three mighty rivers, this resilient city has reinvented itself through the years from a smoky industrial "Steel City" to a modern city of technology, culture, and world class hospitals and universities.

While on this excursion, travel through many of the city's unique neighborhoods and hear the colorful stories of what makes Pittsburgh, Pittsburgh. Enjoy an exploration of Pittsburgh's South Side and former Steel mill sites, as well as its Eastern neighborhoods, including Millionaire's Row, and the Downtown Golden Triangle. In the Northside, enjoy the iconic sites in Pittsburgh's playground, home to Heinz Field, PNC Park, and the National Aviary. And of course, no visit to the city would be complete without a stop atop Mount Washington to view the spectacular Pittsburgh Skyline.
Activity Level: Low | ADA Accessible: Yes

The Ultimate Experience at Acrisure Stadium
Explore the home of the Pittsburgh Steelers with an exciting behind-the-scenes look at Acrisure Stadium. Step beyond the stands and into the places where football history, tradition, and game-day excitement come together.

Your guided stadium experience includes access to the Field Level, where you can take in the atmosphere from a player’s perspective, as well as a visit to the Steelers Locker Room for an insider’s look at where the team prepares for game day. Continue through the impressive FedEx Great Hall, filled with the energy of Steelers football, and be sure to see the famous Heinz Ketchup Bottle displayed above Gate C, one of the stadium’s most recognizable features.

During this engaging excursion, enjoy plenty of opportunities to learn more about the Steelers, Acrisure Stadium, and the traditions that have made the team one of the NFL’s most iconic franchises. Following your stadium exploration, delight in free time to browse the official team store and shop for Steelers apparel, memorabilia, and souvenirs to commemorate your visit.
Activity Level: Moderate | ADA Accessible: Yes

Day 16: Pittsburgh, PA | Disembark

  • 1 Breakfast
Conclude your grand Ohio River voyage in this distinctive city, boasting frontier-town roots and the unassuming charm of the Midwest. As you journey home, take a moment to reminisce about the myriad of remarkable experiences you've encountered, or seize the opportunity to stay a little longer in this industrious city.

Ship/Hotel

American Melody

Sun deck

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Deals

Special Offers 23942
Promotional rates are available on select departures for a limited time. These offers cannot be combined with other discounts and are only valid on new bookings.  Please discuss with your trip planner about applicable dates and cabin types.
Applies to select departures

Per person starting at
$9,920 2-3 travelers
Single Balcony
Queen-size bed, full-size private bathroom with a full set of amenities, sliding glass doors open to private balcony, satellite TV and DVD player, complimentary WiFi Size: 250 sq. ft., including balcony
Standard Balcony
King-size bed, full-size private bathroom with a full set of amenities, sliding glass doors open to a private balcony, sitting area, writing desk, satellite TV and DVD player, complimentary WiFi Size: 275 sq. ft., including balcony
Deluxe Balcony
King-size bed, full-size private bathroom with a full set of amenities, sliding glass doors open to private balcony, sitting area, writing desk, satellite TV and DVD player, complimentary WiFi, Size: 316 sq. ft., including balcony
Premium Balcony
King-size bed that can convert to two twin beds, full-size private bathroom with a full set of amenities, sliding glass doors open to private balcony, sitting area, writing desk, satellite TV and DVD player, complimentary WiFi. Located on the top deck, these spacious staterooms feature commanding views of the passing river landscapes. Size: 350 sq. ft., including balcony
Veranda Suite
King-size bed that can convert to two twin beds, full-size private bathroom with a full set of amenities, large living area, sliding glass doors open to private balcony, satellite TV and DVD player, complimentary WiFi. Size: 405 sq. ft., including balcony
Grand Suite
Grand Suite
King-size bed, floor-to-ceiling glass windows offering 270-degree panoramic views, large balcony, private dining area, full-size private bathroom with a full set of amenities, satellite TV and DVD player, complimentary WiFi, individual climate control. Each Grand Suite features a separate bedroom and living area, ideal for gathering with family and friends after an invigorating day of exploration. Size: 650 sq. ft., including balcony
Included
  • 15 Breakfasts, 13 Lunches, 14 Dinners
  • 15 Nights Accommodations
  • Accommodations as listed
  • Ground transportation as listed
  • Activities as listed
  • Meals as listed
  • Access to a 24-7 Emergency line while traveling
  • Snacks
  • Onboard Entertainment 
  • Onboard gratuities
  • Port charges and fees
  • Complimentary cocktail parties
  • Dining service
  • WiFi provided by Starlink
  • Wine and beer service each afternoon and evening
  • Resident historians and experts who lead discussions and enlighten as you sail
  • Personalized experiences with a dedicated guest programs staff
Excluded
  • Travel Insurance
  • Personal Expenses
  • Flight costs (please request a quote)
  • Additional excursions during free time
  • Fuel and transportation surcharges (when applicable)
  • Premium and Signature shore excursions

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Our guide and driver were very good with their knowledge and were very helpful with our questions. It was a very pleasant visit that would have been impossible to do on our own. Hotels and restaurants were fantastic. The special places we got to go to, like the kitchens, were great. Enjoyed the entire trip!
Meyer Smolen

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