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Select one of the below 5 best Main River trips for 2026 and 2027. Your local English-speaking guide will lead your small group or personalized private tour on an extraordinary adventure exploring Frankfurt. Our Main River trips for 2026 feature Wine Tasting, Archaeological Site Visits, Village Visits, Urban Exploration, and Biking, and start from $1,883 for trips of 7 to 10 days. Contact Adventure Life's Main River trip planning experts to start planning your next seamless trip.
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Strasbourg at dusk
from $1,883
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The Valley of the Romantic Rhine, the Moselle and the Main

Strasbourg Roundtrip - 7 Day Itinerary aboard MS La Boheme
  • Enjoy Strasbourg at night
  • Visit Cochem, Pearl of the Moselle
  • See the unique Reichsburg Castle
  • Discover the famous Lorelei Rock
Starts / Ends
Strasbourg / Strasbourg
Activities
Hiking
Activity Level
Variable
Discover three extraordinary rivers: the enchanting Rhine, the graceful Moselle, and the charming Main, on this incredible 7-day cruise aboard La Boheme exploring this romantic region. Delight yourself with the enchanting city of Frankfurt with its mix of ancient and modern sites that are sure to astonish you.
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River through Koblenz Germany
from $2,014
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The Valley of the romantic Rhine, the Moselle and the Main

Strasbourg Roundtrip - 7 Day Itinerary aboard MS Gérard Schmitter
  • Cruise Iffezheim & Gambsheim locks
  • Enjoy Strasbourg at night
  • Visit the unique Reichsburg Castle
  • Join an exclusive wine tasting
Activity Level
Variable
Explore the enchanting cities of Strasbourg, Frankfurt, Cochem, Koblenz, Rudesheim and Mannheim on this 7-day river cruise aboard the MS Gérard Schmitter. As you travel the Rhine, Moselle, and Main rivers, you'll have the chance to tour ancient towns, bike through verdant valleys, savor the local wines, and explore castles.
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Traditional colorful houses in La Petite France, Strasbourg, Alsace, France.
from $6,450
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Rhine River: Castles, Culture and Culinary Delights

Basel - Cologne - 8 Day Itinerary aboard Connect
  • Tour Strasbourg’s Old Town
  • Wine tasting in Alsace
  • See Gutenberg’s Bible
  • Walk Black Forest trails
Starts / Ends
Basel / Cologne
Activities
Local Market Visits
Activity Level
Variable
Sail from Basel to Cologne aboard Connect on this 8-day European river cruise, journey through Switzerland, Germany, and France, discovering medieval towns, scenic vineyards, and cultural landmarks.
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Ehrenfels Castle on Rhine River near Rudesheim
from $2,431
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5 Different Rivers: The Rhine, Neckar, Main, Moselle, and Saar (Port-to-port cruise)

Strasbourg to Luxembourg - 9 Day Itinerary aboard MS Leonardo Da Vinci
  • Enjoy Heidelberg Castle guided tour
  • Rudesheim vineyard wine tasting
  • Enjoy Rhine Valley scenic sailing
  • Explore Saarburg’s old town
Starts / Ends
Strasbourg / Remich
Activity Level
Variable
Set sail on a 9-day Rhine and Moselle river cruise from Strasbourg to Luxembourg aboard MS Leonardo Da Vinci. Discover Heidelberg Castle, Mainz Cathedral, and Trier’s Roman ruins. Explore Frankfurt, Rüdesheim’s vineyards, Cochem Castle, and Luxembourg’s historic city center. Enjoy wine tastings, guided tours, and unique cultural landmarks.
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Romantic evening light over Basel
from $5,496
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Reflections on the Rhine (Southbound)

Amsterdam to Basel - 10 Day Itinerary aboard Avalon Imagery II
  • Explore Amsterdam’s canals
  • Discover Nijmegen’s Roman ruins
  • Taste Rüdesheim wines
  • Visit Strasbourg’s La Petite France
Starts / Ends
Amsterdam / Basel
Activities
Wine Tasting, Village Visits, Archaeological Site Visits, Urban Exploration, Biking
Activity Level
Variable
Experience Europe’s Rhine River from Amsterdam to Basel for 10 days on Avalon Imagery II. Explore Amsterdam’s canals, Nijmegen’s Roman ruins, Cologne Cathedral, Rhine Gorge castles, Rüdesheim vineyards, Heidelberg Castle, Strasbourg’s La Petite France, and the Black Forest with guided tours, tastings, and scenic walks.
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