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Top Main River Trips & Tours in September 2026

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Discover Main River in September 2026 on one of these 10 tours hand-selected by the travel experts at Adventure Life. Explore the best of during September 2026 as you enjoy Village Visits, Wine Tasting, Archaeological Site Visits, Hiking, and Biking. Prices for trips in September 2026 range from $1,995 to $26,590 for a vacation of 7 to 15 days. Choose any of the below 10 itineraries in September 2026 and customize it when you contact one of Adventure Life's expert Main River trip planners.
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Explore historic Bamberg
from $4,849
$2500
EXPLORE

Europe's Rivers & Castles - Cruise Only

Nuremberg - Luxembourg - 8 Day Itinerary aboard MS Amacerto
  • Explore Wurzburg’s Baroque splendor
  • Discover Bamberg’s architecture
  • Stroll Wertheim’s charming streets
  • Visit Rudesheim’s vineyard gondola
Starts / Ends
Nuremberg / Luxembourg
Activities
Hiking, Biking
Activity Level
Variable
Set sail on an 8-day river cruise aboard the MS Amacerto, exploring Europe’s charm from the scenic Main River to the Upper Middle Rhine Valley's castles and Moselle's vineyards. Visit picturesque villages like Bernkastel, Cochem, and Rothenburg, admire the Wurzburg Residenz fresco, and savor German wines and smoked beer.
Cruise Details
0
River through Koblenz Germany
from $2,348
EXPLORE

The Valley of the romantic Rhine, the Moselle and the Main

Strasbourg Roundtrip - 7 Day Itinerary aboard MS Gérard Schmitter
  • Cruise Iffezheim & Gambsheim locks
  • Enjoy Strasbourg at night
  • Visit the unique Reichsburg Castle
  • Join an exclusive wine tasting
Activity Level
Variable
Explore the enchanting cities of Strasbourg, Frankfurt, Cochem, Koblenz, Rudesheim and Mannheim on this 7-day river cruise aboard the MS Gérard Schmitter. As you travel the Rhine, Moselle, and Main rivers, you'll have the chance to tour ancient towns, bike through verdant valleys, savor the local wines, and explore castles.
Cruise Details
0
Strasbourg at dusk
from $1,995
EXPLORE

The Valley of the Romantic Rhine, the Moselle and the Main

Strasbourg Roundtrip - 7 Day Itinerary aboard MS La Boheme
  • Enjoy Strasbourg at night
  • Visit Cochem, Pearl of the Moselle
  • See the unique Reichsburg Castle
  • Discover the famous Lorelei Rock
Starts / Ends
Strasbourg / Strasbourg
Activity Level
Variable
Discover three extraordinary rivers: the enchanting Rhine, the graceful Moselle, and the charming Main, on this incredible 7-day cruise aboard La Boheme exploring this romantic region. Delight yourself with the enchanting city of Frankfurt with its mix of ancient and modern sites that are sure to astonish you.
Cruise Details
0
Traditional colorful houses in La Petite France, Strasbourg, Alsace, France.
from $6,450
EXPLORE

Rhine River: Castles, Culture and Culinary Delights

Basel - Cologne - 8 Day Itinerary aboard Connect
  • Tour Strasbourg’s Old Town
  • Wine tasting in Alsace
  • See Gutenberg’s Bible
  • Walk Black Forest trails
Starts / Ends
Basel / Cologne
Activities
Village Visits, Local Market Visits
Activity Level
Variable
Sail from Basel to Cologne aboard Connect on this 8-day European river cruise, journey through Switzerland, Germany, and France, discovering medieval towns, scenic vineyards, and cultural landmarks.
Cruise Details
0
Brilliant tulips growing near Amsterdam
from $13,190
2for1
EXPLORE

Splendours of Europe

Amsterdam - Budapest - 15 Day Itinerary aboard Emerald Sky
  • Discover Amsterdam’s canals
  • Explore Cologne’s Old Town
  • Admire castles along Rhine Gorge
  • Stroll Miltenberg’s medieval street
Starts / Ends
Amsterdam / Budapest
Activity Level
Variable
Join this 15-day Splendors of Europe cruise on the Emerald Sky from Amsterdam to Budapest. Cruise through the Netherlands, Germany, Austria, Slovakia, and Hungary. Experience stunning landscapes, medieval towns, and hikes to hilltop fortresses. Explore four capital cities, each providing a distinctive perspective on the region's rich history.
Cruise Details
0
Explore the inspiring Amsterdam
from $13,190
2for1
EXPLORE

Splendours of Europe

Amsterdam - Budapest - 15 Day Itinerary aboard Emerald Destiny
  • Explore Amsterdam’s canals
  • Admire Rhine Gorge’s castles
  • Wander Miltenberg’s cobbled lanes
  • Visit Wurzburg’s Baroque palace
Starts / Ends
Amsterdam / Budapest
Activity Level
Variable
Embark on the 15-day Splendours of Europe cruise aboard the Emerald Destiny, traveling from Amsterdam to Budapest. Discover the wonders of the Netherlands, Germany, Austria, Slovakia, and Hungary while indulging in a glass-top canal boat excursion in Amsterdam. Throughout the visit to four capital cities, immerse in rich history of the region.
Cruise Details
0
Ehrenfels Castle on Rhine River near Rudesheim
from $2,606
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5 Different Rivers: The Rhine, Neckar, Main, Moselle, and Saar (Port-to-port cruise)

Strasbourg to Luxembourg - 9 Day Itinerary aboard MS Leonardo Da Vinci
  • Enjoy Heidelberg Castle guided tour
  • Rudesheim vineyard wine tasting
  • Enjoy Rhine Valley scenic sailing
  • Explore Saarburg’s old town
Starts / Ends
Strasbourg / Remich
Activities
Wine Tasting, Urban Exploration, Archaeological Site Visits
Activity Level
Variable
Set sail on a 9-day Rhine and Moselle river cruise from Strasbourg to Luxembourg aboard MS Leonardo Da Vinci. Discover Heidelberg Castle, Mainz Cathedral, and Trier’s Roman ruins. Explore Frankfurt, Rüdesheim’s vineyards, Cochem Castle, and Luxembourg’s historic city center. Enjoy wine tastings, guided tours, and unique cultural landmarks.
Cruise Details
0
Enjoy a quiet moment on the banks of the Danube
from $13,190
2for1
EXPLORE

Splendours of Europe

Budapest - Amsterdam - 15 Day Itinerary aboard Emerald Dawn
  • Explore Budapest’s grand landmarks
  • Discover Bratislava’s Old Town
  • Tour Vienna’s imperial highlights
  • Visit Melk Abbey’s ancient library
Starts / Ends
Budapest / Amsterdam
Activity Level
Variable
Embark on a 14-day river cruise on the Emerald Dawn, starting in Budapest and exploring cities like Vienna, Wurzburg, and Cologne along the Danube, Rhine, and Main rivers. Experience guided tours and unique cultural highlights, culminating in Amsterdam's vibrant atmosphere.
Cruise Details
0
Explore the unique architecture of Bamberg
from $7,999
EXPLORE

European Jewels

Budapest - Amsterdam - 15 Day Itinerary aboard River Duchess
  • Experience Frankfurt’s
  • Explore Nuremberg
  • Enjoy Rudesheim
  • Discover Vienna
Starts / Ends
Budapest / Amsterdam
Activity Level
Variable
Sail the Danube on a 15-day river cruise from Budapest to Amsterdam aboard the River Duchess. Explore historic cities, stunning landscapes, and cultural treasures with expert-guided tours, wine tastings, and local experiences.
Cruise Details
0
Explore the inspiring Amsterdam
from $5,799
EXPLORE

Grand European Tour: Budapest to Amsterdam

Budapest to Amsterdam - 15 Day Itinerary aboard Viking River Cruises
  • Discover Europe’s castles & culture
  • Visit St. Stephen’s Cathedral
  • See St. Peter’s Cathedral
  • Learn Wertheim's tradition
Starts / Ends
Budapest / Amsterdam
Activity Level
Variable
Join this 15-day Grand European Tour from Amsterdam to Budapest. Explore the beauty, nature, and architecture of Netherlands, Germany, Austria, and Hungary while sailing along the Danube, Main and Rhine Rivers.
Cruise Details
0
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