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Top Main River Trips & Tours in May 2026

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Discover Main River in May 2026 on one of these 11 tours hand-selected by the travel experts at Adventure Life. Explore the best of during May 2026 as you enjoy Wine Tasting, Village Visits, Archaeological Site Visits, Hiking, and Biking. Prices for trips in May 2026 range from $1,995 to $26,740 for a vacation of 7 to 24 days. Choose any of the below 11 itineraries in May 2026 and customize it when you contact one of Adventure Life's expert Main River trip planners.
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River through Koblenz Germany
from $2,348
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The Valley of the romantic Rhine, the Moselle and the Main

Strasbourg Roundtrip - 7 Day Itinerary aboard MS Gérard Schmitter
  • Cruise Iffezheim & Gambsheim locks
  • Enjoy Strasbourg at night
  • Visit the unique Reichsburg Castle
  • Join an exclusive wine tasting
Activity Level
Variable
Explore the enchanting cities of Strasbourg, Frankfurt, Cochem, Koblenz, Rudesheim and Mannheim on this 7-day river cruise aboard the MS Gérard Schmitter. As you travel the Rhine, Moselle, and Main rivers, you'll have the chance to tour ancient towns, bike through verdant valleys, savor the local wines, and explore castles.
Cruise Details
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Strasbourg at dusk
from $1,995
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The Valley of the Romantic Rhine, the Moselle and the Main

Strasbourg Roundtrip - 7 Day Itinerary aboard MS La Boheme
  • Enjoy Strasbourg at night
  • Visit Cochem, Pearl of the Moselle
  • See the unique Reichsburg Castle
  • Discover the famous Lorelei Rock
Starts / Ends
Strasbourg / Strasbourg
Activity Level
Variable
Discover three extraordinary rivers: the enchanting Rhine, the graceful Moselle, and the charming Main, on this incredible 7-day cruise aboard La Boheme exploring this romantic region. Delight yourself with the enchanting city of Frankfurt with its mix of ancient and modern sites that are sure to astonish you.
Cruise Details
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Rathaus in Vienna
from $7,499
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Magnificent Europe - Cruise Only

15 Day Itinerary aboard MS Amastella
  • Marvel Passau cathedrals
  • Wander Durnstein streets
  • Discover Vienna architecture grand
  • Explore Bratislava history
Activity Level
Variable
Embark on a 15-day cruise from Budapest to Amsterdam aboard the MS Amastella, sailing the Danube, Main, and the Rhine through five captivating countries. Explore UNESCO treasures, savor Rieslings, enjoy European cuisine, and adventure through scenic landscapes.
Cruise Details
0
Ehrenfels Castle on Rhine River near Rudesheim
from $2,606
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5 Different Rivers: The Rhine, Neckar, Main, Moselle, and Saar (Port-to-port cruise)

Strasbourg to Luxembourg - 9 Day Itinerary aboard MS Leonardo Da Vinci
  • Enjoy Heidelberg Castle guided tour
  • Rudesheim vineyard wine tasting
  • Enjoy Rhine Valley scenic sailing
  • Explore Saarburg’s old town
Starts / Ends
Strasbourg / Remich
Activity Level
Variable
Set sail on a 9-day Rhine and Moselle river cruise from Strasbourg to Luxembourg aboard MS Leonardo Da Vinci. Discover Heidelberg Castle, Mainz Cathedral, and Trier’s Roman ruins. Explore Frankfurt, Rüdesheim’s vineyards, Cochem Castle, and Luxembourg’s historic city center. Enjoy wine tastings, guided tours, and unique cultural landmarks.
Cruise Details
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Enjoy a quiet moment on the banks of the Danube
from $14,690
2for1
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Splendours of Europe

Budapest - Amsterdam - 15 Day Itinerary aboard Emerald Dawn
  • Explore Budapest’s grand landmarks
  • Discover Bratislava’s Old Town
  • Tour Vienna’s imperial highlights
  • Visit Melk Abbey’s ancient library
Starts / Ends
Budapest / Amsterdam
Activities
Hiking
Activity Level
Variable
Embark on a 14-day river cruise on the Emerald Dawn, starting in Budapest and exploring cities like Vienna, Wurzburg, and Cologne along the Danube, Rhine, and Main rivers. Experience guided tours and unique cultural highlights, culminating in Amsterdam's vibrant atmosphere.
Cruise Details
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Explore Cologne
from $12,590
2for1
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Splendours of Europe

Amsterdam - Budapest - 15 Day Itinerary aboard Emerald Sun
  • Explore Amsterdam’s canals
  • Admire Rhine Gorge castles
  • Tour Rudesheim’s music museum
  • Wander Miltenberg’s medieval street
Starts / Ends
Amsterdam / Budapest
Activities
Local Market Visits
Activity Level
Variable
Experience a 15-day river cruise from Amsterdam to Budapest on the Emerald Sun, visiting cities like Cologne, Vienna, and Bratislava. Enjoy guided tours, local encounters, and stunning sights along the Rhine, Main, and Danube Rivers, ending in Budapest.
Cruise Details
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Place Kleber in Strasbourg
from $5,063
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German Grandeur

Eastbound - 9 Day Itinerary aboard Avalon Tranquility II
  • Explore magical Black Forest
  • Discover Mechanical Music Museum
  • Enjoy the visit in wine producer
  • Explore Bamberg
Starts / Ends
Basel / Nuremberg
Activity Level
Variable
Basel, Switzerland, is the starting point for your magnificent nine-day Germany river trip on Avalon Tranquility II. After that, go on a guided tour of Bamberg before continuing to Nuremberg, where your trip comes to a close.
Cruise Details
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Visit charming Passau
from $8,449
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Magnificent Europe

17 Day Itinerary aboard MS Amastella
  • Stroll Wertheim’s charming streets
  • Explore Nuremberg’s imperial past
  • Marvel at Cologne’s Gothic charm
  • Cruise Amsterdam’s scenic canals
Activities
Land & Sea Exploration
Activity Level
Variable
Embark on a 17-day cruise aboard the MS Amastella, exploring three iconic rivers across five countries. Discover UNESCO World Heritage treasures like Cologne’s Cathedral, Würzburg Palace, and Melk Abbey, while enjoying fine wines, diverse cuisines, and scenic hikes and bike rides in Passau and Vienna.
Cruise Details
0
Romantic evening light over Basel
from $5,696
Save $1500
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Reflections on the Rhine (Southbound)

Amsterdam to Basel - 10 Day Itinerary aboard Avalon Imagery II
  • Explore Amsterdam’s canals
  • Discover Nijmegen’s Roman ruins
  • Taste Rüdesheim wines
  • Visit Strasbourg’s La Petite France
Starts / Ends
Amsterdam / Basel
Activities
Biking, Wine Tasting, Village Visits, Urban Exploration, Archaeological Site Visits
Activity Level
Variable
Experience Europe’s Rhine River from Amsterdam to Basel for 10 days on Avalon Imagery II. Explore Amsterdam’s canals, Nijmegen’s Roman ruins, Cologne Cathedral, Rhine Gorge castles, Rüdesheim vineyards, Heidelberg Castle, Strasbourg’s La Petite France, and the Black Forest with guided tours, tastings, and scenic walks.
Cruise Details
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Budapest, the capital city of Hungary
from $12,999
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Ultimate European Journey

Amsterdam - Bucharest - 24 Day Itinerary aboard River Duchess
  • Visit to the Bamberg city on foot.
  • Tour the Nazi Party Rally Grounds.
  • Visit the beautiful Golubac castle
  • Visit to Dynasty Palace in Belgrade
Starts / Ends
Amsterdam / Bucharest
Activity Level
Variable
Embark on a 24-day cruise from Amsterdam to Bucharest aboard the River Duchess. Sail through eight nations, visit five capital cities, and explore UNESCO sites like Cologne Cathedral and the Rhine Valley.
Cruise Details
0
Explore the inspiring Amsterdam
from $5,999
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Grand European Tour: Budapest to Amsterdam

Budapest to Amsterdam - 15 Day Itinerary aboard Viking River Cruises
  • Discover Europe’s castles & culture
  • Visit St. Stephen’s Cathedral
  • See St. Peter’s Cathedral
  • Learn Wertheim's tradition
Starts / Ends
Budapest / Amsterdam
Activity Level
Variable
Join this 15-day Grand European Tour from Amsterdam to Budapest. Explore the beauty, nature, and architecture of Netherlands, Germany, Austria, and Hungary while sailing along the Danube, Main and Rhine Rivers.
Cruise Details
0
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