Have questions? We're here.
Visit castle ruins in the German countryside

Top Moselle River Trips & Tours in September 2025

Travel made your way
Talk with an expert
Build your ideal Moselle River trip. Call 1.406.541.2677
Start Planning My Trip
Discover Moselle River in September 2025 on one of these 10 tours hand-selected by the travel experts at Adventure Life. Explore the best of during September 2025 as you enjoy Biking, Wine Tasting, Hiking, Village Visits, and Land & Sea Exploration. Prices for trips in September 2025 range from $4,639 to $82,500 for a vacation of 7 to 15 days. Choose any of the below 10 itineraries in September 2025 and customize it when you contact one of Adventure Life's expert Moselle River trip planners.
Filter (10 Results)
  • Start Date
    OR, More specific start
  • Length
    to
  • Price
    to
  • Activity Levels
  • Experiences
  • Activities
  • Ships
  • Destinations
    • Moselle River
Cochem town on the Mosel River, Germany
from $10,725
EXPLORE

Classic Cruise – Germany & Luxembourg

7 Day Itinerary aboard La Nouvelle Etoile
Activity Level
Variable
Onboard La Nouvelle Etoile, sail through the beautiful canals of Germany and Luxembourg for seven days, stopping at quaint towns along the way. While driving through Trier, the oldest city in Germany, the Porta Nigra, and Pauli Bergweiler's wine cellars are just a few of the numerous historical landmarks to see.
  • Visit the 'Queen of German Castles'
  • Tour Germany’s oldest town
  • Finish the cruise in Luxembourg
  • Enjoy superb European wines
Cruise Details
0
Explore historic Bamberg
from $4,639
CLP
EXPLORE

Europe's Rivers & Castles - Cruise Only

Nuremberg - Luxembourg - 8 Day Itinerary aboard MS Amacerto
Starts / Ends
Nuremberg / Luxembourg
Activities
Hiking, Village Visits, Archaeological Site Visits
Activity Level
Variable
Set sail on an 8-day river cruise aboard the MS Amacerto, exploring Europe’s charm from the scenic Main River to the Upper Middle Rhine Valley's castles and Moselle's vineyards. Visit picturesque villages like Bernkastel, Cochem, and Rothenburg, admire the Wurzburg Residenz fresco, and savor German wines and smoked beer.
  • Explore Wurzburg’s Baroque splendor
  • Discover Bamberg’s architecture
  • Stroll Wertheim’s charming streets
  • Visit Rudesheim’s vineyard gondola
Cruise Details
0
Heidelberg
from $7,399
EXPLORE

Rhine & Moselle Delights

15 Day Itinerary aboard MS Amaprima
Activity Level
Variable
This 15-day Rhine & Moselle River cruise aboard MS Amaprima takes you from Zurich to Basel to Amsterdam, passing through Germany and France along the way. Hike and bike in the lush Rhine Valley, stroll the "Crossroads of Europe" in Strasbourg, and savor the best wines and beers that have made this region famous.
  • Cruise tranquil Lake Lucerne
  • Explore Strasbourg on foot
  • Visit Trier, Germany’s oldest city
  • Admire Amsterdam's beauty
Cruise Details
0
Cochem town on the Mosel River, Germany
from $5,799
No SS
EXPLORE

The Rhine & Moselle (Northbound)

Basel - Amsterdam - 11 Day Itinerary aboard Avalon Imagery II
Starts / Ends
Basel / Amsterdam
Activities
Biking, Wine Tasting, Land & Sea Exploration
Activity Level
Variable
Embark on an 11-day cruise aboard the Avalon Imagery II. Explore the Rhine and Moselle Rivers, starting in Basel. Discover charming cities in Germany, France, and Amsterdam, exploring Breisach, Strasbourg, and the Rhine Gorge while enjoying wine tastings in Bernkastel and a canal cruise in Amsterdam.
  • Explore Black Forest village
  • Visit Strasbourg's Gothic cathedral
  • Discover Heidelberg Castle ruins
  • Taste wine in Bernkastel
Cruise Details
0
Trier
from $5,539
CLP
EXPLORE

Rhine & Moselle Delights - Cruise Only

11 Day Itinerary aboard MS Amaprima
Starts / Ends
Basel / Amsterdam
Activity Level
Variable
Begin this exclusive 11-day cruise in Basel and conclude in charming Amsterdam. This voyage includes a large variety of activities so that you can choose how you want to explore the wondrous delights of the Rhine and Moselle River regions.
  • Explore “La Petite France”
  • Bike along the Rhine River
  • Discover Porta Nigra's secrets
  • Enjoy the fairytale town of Cochem
Cruise Details
0
Cochem
from $4,639
CLP
EXPLORE

Rhine & Moselle Splendors - Cruise Only

Luxembourg - Basel - 8 Day Itinerary aboard MS Amacerto
Starts / Ends
Luxembourg / Basel
Activity Level
Variable
Embark on an 8-day river cruise aboard the MS Amacerto. Discover Roman treasures, enchanting folklore, and cultural gems like Strasbourg and Schwetzingen Palace Gardens on this unforgettable journey.
  • Explore Cochem’s historic castle
  • Cruise Rhine Gorge’s beauty
  • Visit Heidelberg's treasure
  • Taste Rudesheim’s unique coffee
Cruise Details
0
Enjoy time in Dusseldorf
from $6,954
EXPLORE

Vineyards of the Rhine & Moselle

13 Day Itinerary aboard MS Amaprima
Starts / Ends
Amsterdam / Paris
Activity Level
Variable
On this 13-day cruise aboard MS Amaprima, embark in Amsterdam en route to cosmopolitan Paris. Along the way, admire vineyards and picturesque Rhine castles on your way to charming Rüdesheim. Continue to historic Koblenz and cruise through the world’s steepest vineyards along the Moselle River Valley to quaint Cochem and Bernkastel.
  • Explore the Rhine River
  • Admire vibrant Amsterdam
  • Visit a local tavern in Cologne
  • Tour the stunning city of Paris
Cruise Details
0
Frauenkirche church in Nuremberg
from $7,099
EXPLORE

Europe's Rivers & Castles

Prague - Paris - 14 Day Itinerary aboard MS Amaprima
Activity Level
Variable
Embark on a 14-day cruise with 3 nights in Prague and Paris aboard the MS Amaprima. Explore castle-lined shores, storybook villages, and historic treasures while savoring Germany’s famed wines, beers, and Rüdesheim coffee.
  • Explore attractive Prague
  • Admire Nuremberg's Gothic churches
  • Visit the medieval city of Wertheim
  • Sail through the Rhine River gorge
Cruise Details
0
Visit charming towns on the Moselle River
from $4,639
CLP
EXPLORE

Vineyards of the Rhine & Moselle - Cruise Only

8 Day Itinerary aboard MS Amaprima
Starts / Ends
Amsterdam / Luxembourg
Activities
Urban Exploration
Activity Level
Variable
MS Amaprima hosts this exciting 8-day cruise along the Rhine and Moselle. Explore splendid Cologne with its magnificent dome and admire the picturesque Rhine castles on your way to bustling Frankfurt and medieval Heidelberg. Continue to fascinating Koblenz and cruise the beautiful Moselle River Valley to charming Cochem and lovely Bernkastel.
  • Tour the romantic Amsterdam
  • Visit Cologne's cathedral
  • Visit Rudesheim's vineyards
  • Admire beautiful castles
Cruise Details
0
La Nouvelle Etoile Cruising
from $82,500
EXPLORE

Private Charter - Classic Cruise - Germany & Luxembourg Aboard La Nouvelle Etoile

7 Day Itinerary aboard La Nouvelle Etoile
Activities
Local Market Visits
Activity Level
Variable
Explore Germany & Luxembourg on this 7-day private cruise aboard La Nouvelle Etoile to the picturesque destinations along two delightful canals. Among the historic sites along the way are the 12th-century castle Burg Eltz, Trier (the oldest town in Germany), the Porta Nigra, and the private wine cellars of Pauli Bergweiler.
  • Tour Germany’s oldest town
  • Enjoy superb European wines
  • Visit the 'Queen of German Castles'
  • Finish the cruise in Luxembourg
Cruise Details
0
1-10 of 10 Results
  • 1

Top Moselle River Travel Destinations

Moselle River Trips by Departure Date

Moselle River Trips by Duration

Moselle River Trips by Activity

More Reasons

Why Travel With Adventure Life

All News

Recognized By