Top South America Trips & Tours in September 2025

This Galapagos cruise aboard the Tip Top IV takes you beyond the highlights of the Western Islands with 8 days of exciting activity! Enjoy the company of friendly sea lions while snorkeling and make friends with the gentle giant tortoises in Isabela and Santa Cruz.

Torres del Paine National Park offers a combination of unique wildlife and spectacular scenery in one of the most isolated regions of South America. Travel through Punta Arenas, Chile, or El Calafate, Argentina to arrive at EcoCamp. After full days of exploring the park return and rest in comfort in the new Suite Domes!

Take in the sights, sounds, food, and culture as you explore Santiago, Buenos Aires, and Rio de Janeiro. This 10 day itinerary includes free days and optional activities so you can set the pace of your South American vacation!

Spend 5 days touring the western vineyards of Uruguay while exploring Colonia del Sacramento with its rich cultural heritage and the charming area of Carmelo. Visit multiple wineries and taste their own varieties of wine.

Adventure Life's guides and partners has identified the poorest families in the Cachiccata community. The elements can cause damage to homes over time, and many families do not have the extra means to make renovations to their homes. During this 4 day/3 night trip, participants, side-by-side with the family members, will work on cleaning, repairing, and restoring their homes. We stay in the community campground each night to immerse ourselves in the village life. The trip ends with traditional Inca ceremony and offering as a time to reflect over the previous days' experiences.

This week-long river cruise onboard La Perla is ideal for flora and fauna enthusiasts who want to experience the Amazon rainforest. This region of the world is a birding enthusiast's paradise. Also, witness pink river dolphins in a way you've never seen them before.

Board the 100 passenger Galapagos Legend for a unique 4-day cruise exploring the central and eastern islands of the Galapagos archipelago. Get ready to snorkel, hike and encounter wildlife such as sea lions, marine iguanas, and giant tortoises many which are unique to the Galapagos, not found anywhere else in this world

Take the opportunity to meet Argentina’s capital city, Buenos Aires! Often referred to as one of South America’s (and maybe the world’s) most exciting cities, Buenos Aires offers fabulous food, world famous wine, the Tango, amazing art, interesting neighborhoods. The city is interesting by day, and captivating by night.

Experience a 2 day/1 night whitewater rafting trip on the Urubamba River, the sacred river of the Incas. Raft through Class II-IV rapids on this trip that includes one overnight of camping and great food after your day's adrenaline-filled adventure on this great river.

This 2-day extension features an overnight in Copacabana. You will explore Lake Titicaca, at the crossroads of the Andes and the Andean plateau and the world's highest navigable lake. Immerse yourself in the legend that the son of Inti, the sun god, emerged as the first Inca from the waters of Lake Titicaca.

This six day Andean trek takes us around the majestic Mount Ausangate, a peak long considered sacred by the Andean people. Along the way we'll pass stunning glacial lakes and rural highland villages, and soak our muscles in natural thermal waters. After the trek, continue your journey with an add-on trip to Machu Picchu or elsewhere in South America.

Travel from Argentina to Brazil to see Iguazu Falls from two perspectives. View the falls from below in Argentina and then get a panoramic view over the falls from the Brazil side.

Explore Peru's vast jungle with a 3-night stay at Sandoval Lake Lodge. Set amidst a rich biologically diverse haven, Sandoval allows visitors to rise early for otter watching, view Brown Capuchin Monkeys, spot Black Caimans or catch a glimpse of Red-Bellied Macaws. Nature hikes and motor canoeing allow you to get up close to the incredible wildlife.

Enjoy a remote 5-day Bolivia trekking adventure on this expedition in the Cordillera Real, in the majestic Andes Mountains. This trek features remarkable views of glacier-clad peaks and high altitude lakes. You'll visit La Paz, Moon Valley, and the Tihuanaco ruins as well. Enjoy camping, horseback riding, and market visits too!

Embark on the Magellan Explorer on this 17-day cruise to the Falkland Islands and South Georgia. In the austral spring, summer, and fall, large numbers of penguins, whales, seals, and seabirds congregate in the Southern Ocean to feed and reproduce. Present in abundant numbers, these animals will provide endless inspiration for your photographs.

This 5-day itinerary on the Manatee is designed to highlight the incredible biodiversity, wildlife, and natural beauty found in the Amazon.

Savor the flavors of Peru on a 4-day gastronomy tour through Lima, a UNESCO World Heritage city. Indulge in Peruvian delicacies at renowned restaurants