Louisville is a muse to artisans of mixed media – from sidewalk chalk to street fare – to the cultural diversity that quickly captivates the heart of its visitors. Since it is situated on the Ohio River, our Louisville cruises are full of activities. This is one of the most popular destinations for our United States river cruises. The top things to do in Louisville include the Slugger Museum and Factory, where they make the best bats for Major League Baseball, the Kentucky Derby Museum, and Old Louisville, known for its restored Victorian mansions. Let our Trip Planners help you curate a Louisville cruise that fits your needs.