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Top Louisville Trips & Tours

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Select one of the below 3 best Louisville trips for 2025 and 2026. Your local English-speaking guide will lead your small group or personalized private tour on an extraordinary adventure exploring . Our Louisville trips for 2025 feature Urban Exploration, Village Visits, Archaeological Site Visits, Wildlife Viewing, and Small Ship Sailing, and start from $5,275 for trips of 9 to 16 days. Contact Adventure Life's Louisville trip planning experts to start planning your next seamless trip.
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Explore Pittsburgh
from $5,275
Savings
EXPLORE

Ohio River Cruise

Pittsburgh - Louisville - 9 Day Itinerary aboard American Melody
  • Explore Pittsburgh’s rich history
  • Visit historic Marietta, OH
  • Tour Cincinnati’s top sites
  • Experience Louisville Derby legacy
Starts / Ends
Pittsburgh / Louisville
Activities
Small Ship Sailing, Wine Tasting
Activity Level
Variable
Embark on a 9-day cruise along the Ohio River aboard the American Melody from Pittsburgh to Louisville. Discover historic towns and cultural landmarks while enjoying guided tours, historic excursions, and breathtaking river views as you cruise through America’s heartland.
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Visit historic Memphis, Tennessee
from $6,360
Savings
EXPLORE

Mississippi River Gateway Cruise

New Orleans to Louisville - 12 Day Itinerary aboard American Heritage
  • Explore Oak Alley Plantation
  • See Paducah wall murals
  • Explore Sun Studio
  • Visit Elvis Presley’s estate
Starts / Ends
New Orleans / Louisville
Activities
Urban Exploration, Village Visits, Wildlife Viewing, Archaeological Site Visits
Activity Level
Variable
Embark on a 12-day Mississippi River cruise from New Orleans to Louisville aboard American Heritage. Explore iconic sites like Oak Alley, Vicksburg, and Memphis. Enjoy enriching excursions, Civil War history, live music, and Southern cuisine.
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View the iconic arch when you visit St. Louis, gateway to the west
from $9,240
Savings
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Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody
  • Explore historic Marietta, Ohio
  • Explore Maysville’s Railroad
  • Visit Louisville’s Churchill Downs
  • Tour Paducah’s wall murals
Starts / Ends
Pittsburgh / St. Louis
Activity Level
Variable
Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.
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