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Minneapolis - St.Paul Mississippi River Cruises

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Minneapolis is a beautiful city that many of our northern Mississippi River cruises visit. Other major cities you will likely visit on your cruise include St. Louis, Memphis, Baton Rouge, and New Orleans. You will see many gorgeous small towns along the way and visit the highlights of many of the cities mentioned above and more. Learn about the Lewis and Clark expedition, the immigration that built this country, and the intricate lock system of the Mississippi River. Contact our travel specialists to start planning your ideal river cruise today!
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Best Minnesota Cruises |  Minneapolis - St. Paul River Cruises for 2025-2026

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Mississippi River Cruise Deals

Top Deals for Mississippi River Cruises to Minneapolis

Trip Name From Days Summary
Upper Mississippi River $5,635 9 Explore the Upper Mississippi River on this 9-day cruise from St. Louis to Minneapolis aboard the American Melody. Begin in St. Louis, Missouri, and travel through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
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Upper Mississippi River $4,610 9 Explore the Upper Mississippi River aboard the American Heritage on this 9-day cruise from St. Louis to Minneapolis. Begin in St. Louis, Missouri, and travel through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns and take in the diverse scenery.
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Upper Mississippi River $5,635 9 Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Symphony. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
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Complete Mississippi River $15,890 23 Discover the Mighty Mississippi on a 23-day cruise covering 10 states aboard American Melody. Immerse in history, culture, and cuisine from New Orleans to Minneapolis, exploring charming ports along the way.
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Grand Heartland Cruise $12,620 16 Embark on a 16-day Mississippi River cruise from Minnesota to Louisiana aboard American Serenade, exploring St. Paul to New Orleans with stops in La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, and Natchez. Enjoy onboard activities, stunning scenery, and experiences like the Mark Twain Boyhood Home and more.
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Great Lakes and Thunder Bay $9,699 16 Sail from Chicago round-trip on a 16-day Great Lakes and Thunder Bay cruise aboard Victory II and explore scenic ports across the Great Lakes. Cruise through Lake Michigan and Lake Superior on a journey full of natural and historic highlights.
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All Five Great Lakes $6,799 11 Sail the Great Lakes from Toronto to Milwaukee on an 11-day cruise aboard Victory I. Discover Niagara Falls, explore Cleveland’s art scene, experience Detroit’s revival, and visit charming Mackinac Island. Visit iconic landmarks, lively cities, and tranquil islands while uncovering the rich heritage of North America’s Great Lakes region.
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Upper Mississippi River $5,635 9 Set sail for 9 days aboard American Serenade from St. Paul to St. Louis. Walk through historic Summit Avenue, admire La Crosse from Grandad’s Bluff, explore Dubuque’s River Museum, and discover Mark Twain’s legacy in Hannibal. Experience curated onboard programs, live music, and the beauty of the Upper Mississippi’s diverse wildlife.
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