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Complete Mississippi River

New Orleans - St. Paul - Example 23 Day Cruise aboard American Melody
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Embark on a 23-day Mississippi River cruise, spanning 10 states on the American Melody. Explore the cultural tapestry of the Mighty Mississippi, touching on history, charm, and scenic landscapes. From lively New Orleans to Minneapolis, discover Baton Rouge's history, St. Francisville's cotton port, and Natchez's grand homes. Delve into Vicksburg's Civil War story, and Greenville's Mississippi Delta essence, and explore Tunica, Memphis, and St. Louis. Cruise through picturesque Dubuque, Winona, and Red Wing, each offering unique experiences. Conclude in St. Paul, where historic sites and Mounds Park wrap up your Mississippi River cruise aboard the American Melody.
The upper Mississippi regionOak Alley Plantation, Vacherie, LouisianaVisit historic Memphis, TennesseePhoto of colorful cafe bars at the iconic Beale Street music and entertainment district of downtown Memphis, Tennessee, USA, illuminated at nightMississippi River, St. Paul MinnesotaNew Orleans paddlewheel steamer in New Orleans, LousianaExplore the rivers of AmericaVisit historic Minneapolis
Highlights
  • Explore Natchez's Grand Homes Along the Mighty Mississippi's Scenic Banks
  • Visit Oak Alley, an antebellum sugar cane plantation
  • Delve into Baton Rouge's history, featuring landmarks and French influence
  • Unravel Vicksburg's Civil War saga at the National Military Park
Activity Level: Variable
Activity options vary depending on destination and operator. Activity level is determined by the range and intensity of activities you choose to participate in. Discuss with your Trip Planner which options are best for you.
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Full Itinerary

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Day 1: New Orleans, Louisiana

New Orleans is a city alive with music, culture, and history at every turn. Explore its vibrant streets, savor iconic cuisine, and soak up the energy of this unforgettable location. A walk through the French Quarter reveals iron balconies, Creole townhouses, and architectural details that reflect the city’s French and Spanish heritage.

The New Orleans jazz legacy thrives, from street musicians to the traditional performances at Preservation Hall, while local restaurants showcase the bold flavors of Creole cuisine. Along the nearby riverfront, the Mississippi’s role in steamboat commerce and trade comes into focus, making this vibrant port the perfect starting point for a journey on the river.

Day 2: Cruising the Mississippi River | Embark

Board your ship and wave goodbye to New Orleans as your Mississippi River cruise begins. Traveling north, the scenery shifts from the city’s iconic waterfront to the working river corridor. Levees line the banks, cargo vessels move through the channel, and bustling port facilities showcase the river’s vital role in American trade and transportation.

Day 3: Oak Alley, Louisiana

This stop along the Great River Road highlights the landscapes and stories of the lower Mississippi. Visit Oak Alley, a 19th-century Greek Revival mansion built during the region’s sugar boom and known for its avenue of live oaks. Explore the grounds, wander beneath the oaks, and see how the property evolved from a working farm into a preserved historic site. Step inside the interiors and learn about its role in the sugar industry.

You can also join a Cajun cooking experience, prepare jambalaya while hearing traditional folktales and learning how these recipes have been passed down through generations.

Another option is a narrated boat ride through nearby wetlands, where cypress and tupelo trees draped in Spanish moss frame the waterways. From a covered boat, look for wildlife such as alligators, nutria, turtles, and wading birds in this part of the Mississippi River Delta ecosystem.

Oak Alley Estate - Complimentary Excursion
From its canopy of 300-year-old oaks to its vast open spaces, Oak Alley's landscape tells the story of a southern plantation over time. Over 200 years ago, Oak Alley was just a land claim on a map and has since served many purposes, including as a sugar plantation, a rice farm, a chicken farm, a cattle ranch, and a country home. Agricultural tycoons, sugar planters, slaves, immigrant laborers, and real estate speculators have traversed its grounds over time.

Today, Oak Alley is a National Historic Landmark dedicated to preserving and interpreting the history of its inhabitants. With an emphasis on its time as a sugar plantation, visitors are invited to walk under its iconic alley, explore the exhibits, interact with staff, and leave with a richer, more powerful understanding of this plantation's complex history. For the full Southern experience, don't forget to take time for a complimentary mint julep. 
Activity Level: High | ADA Accessibility: Partial

Day 4: Baton Rouge, Louisiana

Welcome to Baton Rouge, the capital of Louisiana, whose name comes from a “red stick” that once marked a boundary used by the Native Americans. The city echoes with the stories of its most notable figures, particularly the bold Governor and Senator Huey P. Long. His political and architectural legacy is reflected in landmarks such as the Old State Capitol Museum, housed in a majestic Gothic-style castle from 1852, and the current 34-story State Capitol, a striking example of Depression-era Art Deco architecture built from Louisiana limestone and adorned with marble.

Discover Capitol Park Museum, where Louisiana’s vibrant culture comes to life, from the sounds of Louis Armstrong to the pageantry of Mardi Gras traditions. Walk in history’s footsteps on a guided exploration of key Civil War sites tied to the Battle of Baton Rouge. Visit Magnolia Cemetery and stand on the very ground where some of the conflict’s most intense moments unfolded.

Follow downtown along the Baton Rouge Riverfront, where modern art, river views, and old architecture blend seamlessly. Browse local shops and experience the dynamic energy of a city shaped by a rich and complex past.

The Battles of Baton Rouge - Complimentary Excursion
Led by an expert historian, explore locations that were critical to the Battle of Baton Rouge and hear about the history surrounding Vicksburg in the Civil War. Visit the historic Magnolia Cemetery and stand upon the very ground where the most intense fighting of the battle took place. Baton Rouge was the most fought over land in Louisiana’s history and this experience will cover not only the Civil War, but the American Revolution and the Florida Rebellion. Although the landscape of Baton Rouge isn’t the same as it was in the 1780s or 1810s, its history will be brought to life by your guide. Visit the Magnolia Mound Plantation, a Baton Rouge city park. Magnolia Mound, unlike other antebellum house museums along the Lower Mississippi, is not your grand mansion. Rather, it’s a simple structure built during Louisiana’s colonial history, and around the time of its Statehood into the Union. 
Activity Level: Moderate | ADA Accessible: Yes

Baton Rouge City Experience – Complimentary Excursion
Join us for a captivating exploration of Baton Rouge, where you'll admire and pass by the stunning architecture of the Governor's Hall, the historic Old Louisiana State Capitol, along with the picturesque Magnolia Mound and other notable landmarks.

You will make a stop at the New State Capitol & Arsenal, the tallest capitol building in the United States. Explore its grand hallways, art collections, and panoramic views from the observation deck. Adjacent to the capital, the historic Arsenal provides insight into the military history of the region.
Activity Level: Low | ADA Accessible: Yes

Capitol Park Museum Exploration - Complimentary Excursion
Begin this excursion with a brief city exploration before arriving at the Capitol Park Museum. Learn about the many diverse aspects of Louisiana from Louis Armstrong to Mardi Gras. We will then continue by motorcoach for a narrated exploration as we view the impressive Governor's Hall and the New State Capitol, as well as the Old Louisiana State Capitol, also known as the State House.
Activity Level: Low | ADA Accessible: Yes

Day 5: St. Francisville

Perched high above the river, St. Francisville invites you to step into a world of small-town charm infused with Southern Gothic intrigue. Set on bluffs protected from flooding, this scenic destination connects the lower Mississippi’s estates with the Delta’s natural landscapes.

Visit The Myrtles, an 18th-century estate where history and mystery intertwine. Stroll through the beautifully preserved grounds of Rosedown, known for its expansive gardens and refined architecture.

Explore the Audubon State Historic Site to discover the region’s artistic and natural legacy, then venture to the Port Hudson Historic Site, where pivotal Civil War events unfolded. Wander the district, where Royal Street, century-old churches, and preserved community buildings showcase the town’s character.  

The Myrtles - Complimentary Excursion
At first glimpse Myrtles, built in 1796, envelopes one with a complete sense of peace and tranquility. However, it is reputed to be one of the most haunted homes in America. Surrounded by centuries-old live oak trees, the mansion features a 125-foot verandah, exquisite ornamental ironwork, hand-painted stained glass, open-pierced frieze work crown molding, Aubusson tapestry, Baccarat crystal chandelier, Carrara marble mantels, gold-leafed French furnishings, and ghosts.
Activity Level: Moderate | ADA Accessibility: Yes

St. Francisville Local Loop – Complimentary Excursion
Board this convenient motorcoach, making stops at: 
Town Hall - Access to local boutiques, bookstore, and coffee shop for an experience that supports local artists and purveyors.
Audubon Market, Elliot’s Pharmacy, and Patrick’s Jewelry - Forgot something at home? No worries, everything you need can be found at either the Audubon Market or Elliot’s Pharmacy. While you're here, don’t forget to pick up something for your loved ones at Patrick’s Fine Jewelry and Gifts.
Sage Hill / Post Office - Local store for gifts / Post Office.
West Feliciana Museum, Away Down South Gift Shop - Located in the town’s former hardware store, learn about the fascinating history of St. Francisville, or stop in for a refreshing treat at Away Down South Gift Shop.
Grace Church and Cemetery - Built in 1860, you can stroll the grounds or explore the historic cemetery of one of the state’s oldest surviving Protestant churches. Activity Level: Partial | ADA Accessible: Yes

Cochon De Lait Experience - Complimentary Excursion
Experience a traditional Louisiana Cochon De Lait serenaded by local musicians. Cochon de lait is the centuries-old Cajun heritage, centered on cooking a whole pig over an open hardwood fire, infused with Native, French, African, and Caribbean influences and celebrated across Cajun country. Delight in the flavors of slow-roasted cochon, Louisiana boudin, traditional potato salads, seasonal vegetables, as well as bread, crackers, and sauces to accompany dishes. As tradition, there will be an opportunity for dancing after the feast.  
Activity Level: Low | ADA Accessible: Yes

Day 6: Natchez, Mississippi

In the heart of Natchez, where the Mississippi River bends, grand homes stand as a testament to the city’s wealth as a major river port. After the French built a fort here in 1716 near communities of the Natchez people, the settlement grew into one of the most prosperous towns along the river. Largely preserved despite early Union occupation during the Civil War, Natchez remains home to one of Mississippi’s most intact collections of iconic residences.

Discover the stunning Rosalie Mansion, known as “Our Lady on the Bluff.” Led by a guide, explore this beautiful home overlooking the river, with elegant interiors and period furnishings that offer a glimpse into Natchez’s past. Then relax and experience the town the old-fashioned way, by horse-drawn carriage, while listening to tales of the city’s rise as one of America’s wealthiest before the Civil War.

Natchez Local Loop- Complimentary Excursion
Board this convenient shuttle, making stops at:
Fort Rosalie & Trading Post - Fort Rosalie was built by the French in 1716 within the territory of the Natchez Native Indians and it was part of the French colonial empire, becoming the first settlement in present-day Natchez, Mississippi. Walk the hallowed grounds of the long-gone fort and enjoy perusing the gift items of the modern trading post. 
Historic Natchez in Photos - Visit the Stratton Chapel Gallery in downtown Natchez behind First Presbyterian Church. View an outstanding collection of photographs taken from as early as 1860, including family portraits, steamboats, and street scenes.
Main Street & Franklin Street - Explore the few one-of-a-kind antique shops or just walk among the many beautifully restored historic buildings of this lovely town.
Historic Natchez Bluffs & Gazebo - Sitting 200 feet above the banks of the Mississippi River, the Gazebo offers the best vantage point from which to take in the river’s natural splendor.
Rosalie House - Visit Rosalie, an antebellum mansion in downtown Natchez. Excursions begin at the top of every hour. Make sure to wear your lanyard for complimentary entry.
Activity Level: Low | ADA ACCESSIBLE: Yes

Natchez Landmark Exploration - Complimentary Excursion
Experience a multitude of National treasures, historic sites, and local points of interest from the comfort of your motorcoach. Natchez boasts more National Landmarks than any other town in Mississippi. Begin your exploration at the mighty Natchez Bluffs overlooking the Mississippi River. Your local guide will entertain you with local lore and legends, in addition to historical facts. View historic architectural gems, African American sites, local favorites, and a few quirky places. Complete your experience with a complimentary guided exploration of Historic Rosalie Mansion, so exquisite, that she’s known as "Our Lady on The Bluff."
Activity Level: Low | ADA Accessibility: No

Day 7: Vicksburg, Mississippi

Overlooking the river, Vicksburg is best known for its pivotal role in the Civil War and its commanding views of the waterway that shaped its past. Visit Vicksburg National Military Park, where preserved battlefields, monuments, and the restored ironclad USS Cairo tell the story of the decisive campaign that helped turn the tide of the war. 

On a guided excursion, explore Vicksburg’s oldest neighborhood, where you can admire the Duff Green Mansion, once a hospital during the 47-day siege, and Tully’s Cave, which reveals how residents survived the bombardment.
Finally, walk through downtown to discover historic architecture, riverfront murals, museums, and local shops that reflect the city’s connection to the Mississippi River.

Vicksburg National Military Park- Complimentary Excursion
A knowledgeable guide will lead you through the National Military Park which commemorates the campaign, siege, and defense of Vicksburg in 1863. Stop at the impressive Illinois Monument, modeled after the Roman Pantheon. The exploration concludes at the Visitors Center where life-sized exhibits and artifacts from the Siege of Vicksburg are on display.
Activity Level: Low | ADA ACCESSIBLE: Partial

Vicksburg Local Loop - Complimentary Excursion
 Board this convenient shuttle making stops at:

Tully’s Cave – Explore this modern-day replica of the underground shelters used by Vicksburg residents during the Civil War's 47-day siege in 1863.
Local Merchant District – Stroll through downtown Vicksburg and browse a few local shops.
Old Courthouse Museum – Built in 1858, this museum is a national historic landmark showcasing Vicksburg’s cultural heritage over the past 71 years. The museum’s collection includes the original Teddy Bear given to a local child by Theodore Roosevelt, a sash worn by both George Washington and Jefferson Davis during their presidential inaugurations, a vast collection of Civil War artifacts, Native American and pioneer implements, and much more.
Biedenharn Coca–Cola Museum – This unique museum celebrates the history of one of the nation's most beloved beverages. Built in 1890, the building is the location where Coca-Cola was bottled for the first time in 1894 and features the type of equipment that Joseph Biedenharn used at the time. View Coca-Cola memorabilia, peruse the gift shop, and treat yourself to an ice-cold Coke float.  
Vicksburg Civil War Museum – Visit the Vicksburg Civil Museum and see an impressive collection of weapons, ammunition, uniforms, and other Civil War materials. 
Lower Mississippi River Museum – Experience life on the Mississippi River. Through both interactive and static displays, discover how different communities, farming families, and the US Army Corps of Engineers have all utilized the river in the past and learn about the future for the Mississippi River Valley. Examine the science behind water movement and view some of the river's fish up close in the museum’s 1,515-gallon aquarium.
Catfish Row Museum – Learn diverse aspects about Vicksburg – from its music, history, and storytelling to its vibrant food heritage.
Old Depot Museum – The museum exhibits examine earlier modes of transportation, the Siege of Vicksburg, and many other elements of the city’s history. Inside the museum, you will find railroad memorabilia, a collection of model Civil War gunboats, original war-themed paintings by Herb Mott, a detailed diorama of the Siege of Vicksburg, and models of architecture styles employed throughout Vicksburg’s past.  
Activity Level: Low | ADA Accessible: Yes

Day 8: Greenville, Mississippi

Dubbed the heart and soul of the Mississippi Delta, Greenville invites you into a landscape and culture shaped by fertile farmland, river life, and the enduring legacy of the blues. Set along the shores of Lake Ferguson and surrounded by levee-protected fields, this storied town reflects the agricultural backbone of the region, where cotton once ruled and a distinct cultural identity took root.

Experience the origins of blues at the B.B. King Museum and Delta Interpretive Center, where the life of B.B. King is shared alongside the broader tale of Mississippi’s musical heritage. Through immersive exhibits and vivid storytelling, uncover how this iconic music emerged.

B.B. King Museum & Delta Interpretive Center - Complimentary Excursion
The B.B. King Museum and Delta Interpretive Center is located in the heart of the Mississippi Delta between Greenwood and Greenville. Opened in mid-September 2008 and built to honor the life and music of one of the most accomplished musicians of that time, the museum serves as a vital resource to the State of Mississippi and the City of Indianola. The museum’s exhibits and educational programs were designed to preserve the rich cultural and musical heritage of the Mississippi Delta.
Activity Level: Low | ADA Accessibility: Yes

Greenville Museum Shuttle - Complimentary Excursion
Explore three museums in the city of Greenville at your leisure. The Greenville History Museum is housed in the restored Miller Building and provides a glimpse into local history from the late 1800s to the 1970s. The 1927 Flood Museum commemorates one of the country’s worst natural disasters in history, the break in the levee, which is reported to have put flood waters over the rooftops of houses 75 miles away. At the Jewish Temple Museum, learn how this religion began to flourish within the region.
Activity Level: Low | ADA Accessibility: Yes

Day 9: Tunica, Mississippi

Discover Tunica, a charming Delta river town where the Mississippi and its levees shape the landscape and daily life. Stop by the riverfront for sweeping views of the water and surrounding farmland, and experience firsthand how this mighty river has influenced the culture, past, and rhythm of the Delta.

Among Tunica’s must-see attractions is the Gateway to the Blues Museum, where exhibits display the rich musical traditions of the Mississippi Delta and the artists who defined the blues. Nearby, Tunica river park offers another perspective on the region, with museum displays highlighting the geology, wildlife, and cultural history of the lower Mississippi. Set along a scenic riverwalk, the museum overlooks the water, where visitors can see views from the ship’s dock.

Gateway to the Blues Museum - Complimentary Excursion
Before you trek through blues country, get in a blues state-of-mind at the Gateway to the Blues Museum, set in a rustic train depot, circa 1895. Here, the story of the blues comes to life in all its tormented and anguished glory. Experience interactive exhibits, view amazing artwork, and more, including a recording studio where you’ll learn the basics of blues music with a chance to record your very own blues song.

Tunica RiverWalk and Museum - Complimentary Excursion
The Tunica River Museum features stunning boat shaped architecture and is just a short walk from the ship. Enjoy a variety of authentic artifacts and exhibits which showcase the history, nature, and culture of the region. Engaging displays illustrate the geologic, natural, and cultural history of the Lower Mississippi River and its current place in American history. On the museum grounds, explore the scenic Tunica RiverPark to enjoy the awe-inspiring beauty of the Mississippi River right where we dock. The grounds are rich with native wildlife and flora, and the stunning RiverPark Overlook provide breathtaking views of the river and a walking path.

Day 10: Memphis, Tennessee

Welcome to Tennessee and the vibrant city of Memphis, a cultural landmark along the Mississippi where musical legacy and civil rights are deeply connected to the river. Walk along Beale Street, home to legendary blues clubs and live venues that carry forward the sounds that shaped the city. 

Step inside Sun Studio, the birthplace of rock ‘n’ roll, and see where music legends recorded their groundbreaking hits. Then visit the National Civil Rights Museum at the Lorraine Motel for a powerful, immersive look into the American Civil Rights Movement.

Celebrate the life of the King of Rock ‘n’ Roll at Graceland, viewing the iconic home, exploring personal artifacts, and tracing the life and influence of Elvis Presley. Take a guided motor coach exploration through downtown Memphis landmarks before returning to the revitalized riverfront.

Memphis City Exploration- Complimentary Excursion
Relax and let your motorcoach guide show you the highlights of this fascinating city on the bluff. Memphis is located on the Mississippi River at the northern end of the Mississippi Delta where the Blues were born. Its history is linked to cotton and music. Along your exploration, stop at the Lorraine Motel, the location where Dr. Martin Luther King, Jr. was assassinated.

The next photo opportunity will be at the famous Sun Studio, the birthplace of rock ‘n’ roll. You will also have the option to walk through the Peabody Hotel and see the famous ducks in the fountain. Enjoy some time at the Memphis Pyramid, housing an impressive Bass Pro Shop, a Lodge, Restaurants and more. During the excursion, you will be driven through the streets of downtown Memphis. You will see Victorian Village, Orpheum Theater, Rock N Soul Museum, St. Jude's Children's Hospital, Cotton Row, Beale Street, Lauderdale Courts, the early home of Elvis Presley, Sun Studio, and the Auto Zone Park. Travel by the National Civil Rights Museum and stop to see The Lorraine Motel.  
Activity Level: Moderate  | ADA ACCESSIBLE: Yes

Beale Street Bound - Memphis Shuttle - Complimentary Excursion
One of the most iconic streets in America, Beale Street is three blocks of nightclubs, restaurants, and shops in the heart of downtown Memphis. Hop aboard a convenient shuttle which runs continually after dark, so you can enjoy this legendary street as it comes to life.  
Activity Level: Low | ADA Accessible: Yes

Memphis Local Loop - Complimentary Excursion
Explore the captivating city of Memphis at your leisure with our convenient shuttle, making stops at:

Beale Street – One of the most iconic streets in America, Beale Street is three blocks of nightclubs, restaurants, and shops in the heart of downtown Memphis.
Edge Motor Museum - Discover the stories behind some of the world’s most iconic cars, including how these cars reflect the eras in which they were designed, built, sold, and driven. 
Memphis Pyramid - Much more than just a retail space, this 535,000-sq. ft. pyramid offers many unique experiences, including the world’s tallest freestanding elevator, an underwater-themed bowling alley, an aquarium, and a variety of one-of-a kind dining destinations.
Activity Level: Low | ADA Accessible: Yes

Day 11: Day of River Cruising

Cruising from Memphis to Cape Girardeau offers a memorable journey along the river’s scenic shores. As the ship travels north, the river gradually narrows, flat farmland stretches along the banks, and the channel curves through tree-lined shores, creating an ever-changing landscape.

Onboard, enjoy expansive river views from the sun deck, lounge, or your private balcony, and take in lively performances or connect with fellow guests, making every moment both relaxing and enriching.

Day 12: Cape Girardeau, Missouri

Cape Girardeau is a quaint Midwestern river community with a walkable downtown. Its waterway is known for large floodwall murals that illustrate the area’s history and connection to river trade. From the shoreline, visitors can also see the Bill Emerson Memorial Bridge spanning the river—a modern landmark that frames views of the upper Mississippi and marks the ship’s entry into this region.

Several attractions lie just steps from the dock, making them ideal for local exploration. Wander through the Cape Girardeau Heritage Museum, housed in a former fire station, where exhibits showcase the city’s growth. Step inside the Red House Interpretive Center, where the story of early founder Louis Lorimier and the notable visit of Lewis and Clark come to life.

Discover Old St. Vincent’s Church and Glenn House to gain insight into daily life in earlier periods, from early settlers to riverfront communities. Stroll through the downtown district to experience the city’s architecture, shops, and local charm.

Cape Girardeau Local Loop - Complimentary Excursion
Board the Cruise Coach and enjoy stops at: 

Old St. Vincent's Church - Standing tall as a great majestic monument to the rich religious tradition and spiritual health of Missouri's Cape Girardeau, this church is a treasure to this area for its beautiful English Gothic Revival architecture and intricate design. 
Red House Interpretive Center - The Center honors the enduring legacy of French-Canadian pioneer Louis Lorimier, founder of the community, and commemorates the historic visit of explorers Meriwether Lewis and William Clark in November 1803. Learn about what life was like during the early 1800's in this area when Cape Girardeau was a mere settlement and trading post.
Glenn House - An example of the Victorian  period lifestyle, the home is an historic treasure; a place that allows visitors an opportunity to visit a world inhabited by earlier generations whose way of life were very different from our own. 
Crisp Museum - Showcasing historical art forms and archaeological artifacts, this space also serves as a platform for talented—often local—artists to present their work to the public in the medium of their choice.
Cape Girardeau Heritage Museum - Housed in the Cape Police and Fire Station of 1908, this museum is dedicated to local history, featuring a variety of engaging exhibits.
Cape's Historic Downtown Shopping District - Explore this area featuring several local businesses,  such as Annie Laurie's, The Indie House, The Corner Store, Mississippi Mutts, and the Visit Cape giftshop.

Mural Walk - Complimentary Excursion
The Mississippi River Tales Mural is the largest and most dramatic of Cape Girardeau's murals and is located on a portion of the floodwall. Covering nearly 18,000 square feet, this 1,100-foot-long mural features 24 historically-themed panels that vividly portray Cape Girardeau's rich history and heritage. Along the way, descriptive markers provide an explanation of each panel.
Activity Level: High | ADA ACCESSIBLE: No

Day 13: Day of River Cruising

Relax as your journey continues along the Mississippi River. Here, locks and dams begin to appear, offering a close look at the system that manages water levels and allows vessels to navigate this section of the river.

The shoreline begins to change as wooded hillsides and quieter riverbanks replace the industrial scenery seen farther south. Take in views from the sun deck, the lounge, or your private balcony while enjoying onboard programming that explores the history and navigation of the river. 

Day 14: St. Louis, Missouri

Approaching the banks of St. Louis, Missouri, the skyline and the Gateway Arch rise along the river, marking one of the major Midwestern cities where the Mississippi and Missouri Rivers meet. Located within Gateway Arch National Park, the Arch stands as a symbol of the nation’s westward expansion and remains one of the most recognized St. Louis attractions.

Enjoy a guided, narrated journey through downtown St. Louis, taking in the riverfront, City Garden, Soulard, Lafayette Square, and Forest Park. Experience the iconic Gateway Arch, explore the pre-boarding exhibits, and ascend 630 feet for breathtaking panoramic views. Then, visit the renowned Anheuser-Busch (Budweiser) facility to see the legendary Clydesdales’ stables, the Brewhouse, and the Beechwood Aging Cellars, where signature beers are crafted to perfection.

Discover St. Louis - Complimentary Excursion
This narrated exploration provides you with a wonderful overview of the city, including downtown St. Louis and the riverfront, City garden Sculpture Park, the historic neighborhoods of Soulard and Lafayette Square, Forest Park, and The Cathedral Basilica of St. Louis, a stunning church which rivals the cathedrals in Rome, Italy.
Activity Level: Low | ADA ACCESSIBLE: Yes

Day 15: Day of Cruising

As you travel the Mississippi River toward Hannibal, taller, more dramatic bluffs and wooded shorelines rise along the banks. From the sun deck, you may also notice small towns and agricultural stretches that reflect the working landscape of this region. 

This portion of the journey offers a slower pace of scenic cruising, giving guests time to relax in one of our lounges, enjoy the coast from a private balcony, or take part in onboard enrichment activities that highlight the culture and history of the river. Don’t miss cocktail hour, a chance to share stories with fellow travelers, before sitting down to a dinner inspired by local flavors.

Day 16: Hannibal, Missouri

Step into the world of Mark Twain in this idyllic river town, where the author’s stories of Tom Sawyer and Huckleberry Finn come to life. Visit the Mark Twain Boyhood Home & Museum to experience life in the 1840s and the events that shaped his legendary writing. 

Stroll the preserved 19th-century streets and join a guided walk with a local interpreter, who brings the town’s story to life through Mark Twain’s own words. Visit Rockcliffe Mansion for stunning views of the river, and explore Mark Twain Cave, one of the region’s most famous natural attractions, for an unforgettable underground adventure. 

Mark Twain Boyhood Home & Museum - Complimentary Excursion
As you arrive in Hannibal, the boyhood home of famous author Mark Twain, relive the author’s experiences that heavily influenced his writings. Visit the actual home that Mark Twain grew up in, which is surrounded by the legendary whitewashed fence of Tom Sawyer. The vivid stories told by Mark Twain come to life at this interactive museum. Visit the Becky Thatcher House, the Huck Finn Home, and the Tom and Huck Statue at the foot of Cardiff Hill. Stop at the Interpretive Center, home to 15 original Norman Rockwell paintings.
Activity Level: Low | ADA Accessibility: Yes
*This excursion is available on the Local Loop

Hannibal Local Loop - Complimentary Excursion
Explore downtown Hannibal at your leisure on this convenient shuttle:  
Downtown - Explore downtown Hannibal on your own. Take time for shopping and strolling through town. 
Mark Twain Boyhood Home & Museum - Enjoy a self-guided exploration of the Mark Twain Boyhood Home & Museum properties. The complex includes five historic homes which include Twain's Boyhood Home, the Becky Thatcher House, Huckleberry Finn House, J. M. Clemens Justice of the Peace office, and the recently restored Grant's Drugstore. Explore the Interpretive Center and the Museum Gallery which includes artifacts of the Clemens family and first editions. The Mark Twain Museum Complex also includes three gift shops, the historic Tom and Huck Statue, as well as seasonal free performances by Tom and Becky and Mark Twain himself. 
LaBinnah Bistro and Laura Hawkins House – At this stop you will have access to the Laura Hawkins House. Laura Hawkins was a real-life inspiration for Becky Thatcher in the Mark Twain books. Across the street at the LaBinnah Bistro, you will be treated to a sweet and savory sampler along with a wine tasting experience to enjoy at your leisure. There will be guides on site to answer questions and share historical information. 
Activity Level: Low | ADA Accessibility: Yes

Day 17: Day of River Cruising

Settle into one of our spacious lounges aboard the riverboat as we continue cruising from Hannibal to Muscatine. On this stretch of scenic river cruising, the channel becomes narrower and we pass through additional locks while hillsides and dense forests rise along the shoreline. From the sun deck or your private balcony, relax and take in the view as we cruise through quieter stretches of the Mississippi River, with occasional sightings of regional wildlife. 

 

Day 18: Muscatine, Iowa

Along the upper Mississippi River in Iowa, Muscatine is a quiet river town with a relaxed pace and easy riverfront access, a noticeable change from the busier lower river cities. Walk along the riverfront where hillside views and tree-lined shores create a serene backdrop for exploration.

Step inside the National Pearl Button Museum to explore Muscatine’s distinctive legacy as the “Pearl Button Capital of the World.” Uncover the fascinating process of crafting buttons from freshwater mussels and see how this once-booming industry shaped the city’s economy and riverfront identity.

Then, venture to Pine Creek Grist Mill, a beautifully restored 19th-century landmark nestled within Wildcat Den State Park. As one of the oldest and most well-preserved gristmills between the Mississippi River and the Rockies, it offers a vivid glimpse into the region’s early milling heritage and rural craftsmanship.

Muscatine Local Loop - Complimentary Experience
Explore the area at your leisure with our convenient motorcoach making stops at: 

Muscatine Environmental Learning Center - Featuring two 1,200-gallon freshwater aquariums, live animals, over 100 mounted specimens, and engaging natural history exhibits, the Learning Center offers an immersive experience for all ages. Located within Discovery Park, visitors can enjoy 1.5 miles of paved walking trails that meander through ponds, woodlands, and prairie landscapes. The park also includes a barn, arboretum, and additional educational spaces for exploration and discovery.
Muscatine Art Center - Step back in time as you explore the charming period rooms of this historic 1908 home, a gift from lumber baron Peter Musser to his daughter and son-in-law. Discover original family belongings, historic furnishings, and artwork from the Mississippi River collection. The center also features rotating exhibits, decorative arts, a serene Japanese Garden, and globally recognized artworks.
The National Pearl Button Museum -  Learn the remarkable story of Muscatine’s pearl button industry, once the largest in the world. Discover how freshwater mussels from the Mississippi River gave rise to a thriving trade that shaped the city’s identity. This one-of-a-kind museum brings history to life through engaging exhibits and rare artifacts.
Activity Level: Low | ADA Accessible: Yes

Day 19: Dubuque, Iowa

Dubuque, Iowa, overlooks the Mississippi River and blends historic architecture with walkable streets. Stroll the revitalized riverwalk and wander the city’s quaint avenues, where preserved buildings bring Dubuque’s past to life.

Ride the Fenelon Place Elevator for a unique view of the steep terrain. Immerse yourself in the National Mississippi River Museum & Aquarium with hands-on exhibits, live wildlife displays, and interactive lessons on river navigation. Travel to the iconic Field of Dreams Movie Site to experience cinematic history, or observe local wildlife and plant life along the scenic waterway.

The Dubuque River Walk – Complimentary Excursion
Join your guide on a short walk along the banks of the Mississippi River on Dubuque’s River Walk. As you stroll along this picturesque path, take in sweeping views of the river’s vast waters and admire the diverse wildlife and native plants. Take to ask questions about the Mississippi River ecosystem and how it affects the cities that call its banks home. Your riverside walk will conclude at the National Mississippi River Museum & Aquarium, where your guide will leave you to explore at your own pace. Inside, learn even more about the Mississippi and other rivers of the world through hands-on exhibits, live animals, historic artifacts, and immersive multimedia experiences.  
Activity Level: Moderate | ADA Accessible: Yes

Day 20: Day of River Cruising

As you sail from Dubuque to Winona, notice the shift into the Driftless Area, a unique geographic region where the river narrows and steep, wooded hills rise along the shoreline. The passage includes more locks and dams, making elevation changes along the Mississippi more visible and adding interest to the journey.

Quiet stretches of river allow for wildlife sightings and a sense of calm, with fewer industrial areas than on the lower river. This segment is one of the most scenic of the itinerary, offering a chance to appreciate the natural beauty and subtle changes of the landscape. 

Day 21: Winona, Minnesota

Framed by towering bluffs and striking limestone cliffs, Winona is a picturesque river town where a charming downtown and scenic riverfront paths invite easy, unhurried exploration.

Explore the Winona County History Center to see exhibits that highlight the area’s cultural heritage and community life over the decades. Drive to Garvin Heights Lookout for breathtaking views that reveal the convergence of the Mississippi River, towns, and surrounding farmland. Visit the Minnesota Marine Art Museum, home to a remarkable collection of European and American marine and fine art.

Take a narrated boat exploration to learn about the interesting past of Winona and its relation to the river. Bring your camera and binoculars to observe local wildlife like eagles, deer, and turtles.

Discover Winona - Complimentary Excursion
Enjoy a guided, in-depth exploration of the historic and intriguing sites around greater Winona. Stops include the Winona County History Center, Minnesota Marine Art Museum, Garvin Heights lookout with amazing views of this stretch of the Mississippi River Valley, and more.
Activity Level: Low | ADA Accessibility: Yes

Downtown Winona Walking Experience - Complimentary Excursion
Take a guided walk through Winona's historic downtown to admire great architecture, hear surprising stories, and play a fun game or two. 
Activity Level: Low | ADA Accessibility: Yes

Winona Local Loop - Complimentary Excursion
Running on a continuous loop, this guided exploration shuttle takes you from the ship to Winona's hot spots including history and art museums, historic places with beautiful architecture and stained glass, and to the heart of Downtown so you can shop, eat, and stroll at your leisure.
Activity Level: Low | ADA Accessible: Yes

Day 22: Red Wing, Minnesota

Overlooking the northern riverbanks, Red Wing has inspired artisans for over 150 years, its striking cliffs and sweeping river views fueling generations of artistic creativity.

Visit the Red Wing Pottery Museum to admire beautifully preserved stoneware and regional folk art that reflect the town’s rich craftsmanship. Take in a performance at the Sheldon Theatre, one of Minnesota’s oldest venues, known for hosting national tours, international artists, and local productions. At the National Eagle Center, get an up-close look at bald eagles in an immersive setting. Finally, stop by the Red Wing Shoe Company flagship store to see the world’s largest boot, standing over 20 feet tall, it’s a true local icon.

National Eagle Center - Complimentary Excursion
Visit the National Eagle Center, offering additional up-close viewing of non-releasable bald and golden eagles. Learn about the ecology, biology, and natural history of these magnificent creatures.
Activity Level: Low | ADA ACCESSIBLE: Yes

Red Wing City Exploration - Complimentary Excursion
Travel back in time as you explore the beautiful city of Red Wing. Led by the local expert guide, view some of the most impressive Victorian homes of the period as well as the historic St. James Hotel. Visit the Pottery Museum of Red Wing and admire the numerous true vintage pieces on site such as stoneware, dinnerware, folk art, and more! Stop at the Sheldon Theatre, among the oldest operating theatres in Minnesota, and host thousands of large national touring acts, international artists, and local performers alike.
 Activity Level: Low | ADA Accessibility: Yes

Red Wing Local Loop – Complimentary Excursion
Explore the highlights of Red Wing on this convenient shuttle to:

Red Wing Marine Museum - Located along the river near the site of the original factory where Red Wing boats and motors were once made and launched. Explore their many exhibits which depict one of oldest of the city’s manufacturing industries. Restored Red Wing Thorobred engines are on display at the museum, along with outboard motors, fishing tackle, other river-related objects, and photographs. 
Goodhue County History Center - Established in 1869, this museum is home to the first county historical society in Minnesota. Learn about Goodhue County’s rich and vibrant history spanning centuries. View two and three-dimensional exhibits that represent every decade of the county’s history, including rare examples of Mississippian and Woodland pottery, as well as terracotta and stoneware products from the pottery companies of Red Wing.
Shopping Area - Stroll around and enjoy the quaint downtown shops. This area is home to the world’s largest boot (over 20 feet tall!) at Red Wing Shoe Flagship store.
Red Wing Arts - Visit this creative art center and gift store, in the historic Red Wing Depot, which celebrates community and creativity and features local art and exhibits.Activity Level: Low | ADA Accessible: Yes

Day 23: St. Paul, Minnesota | Disembark

  • 1 Breakfast
Disembark in this dynamic capital city with convenient access to the Minneapolis/St. Paul airport or extend your stay to explore the region more fully. 
Discover Summit Avenue highlights, including Landmark Center and the historic Rice Park. Stop by the Mississippi River Visitor Center and nearby riverfront parks to trace the upper course of the Mississippi, then continue to Mounds Park for views of the river valley and downtown skyline.

Ship/Hotel

American Melody

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Deals

Special Offers 23942
Promotional rates are available on select departures for a limited time. These offers cannot be combined with other discounts and are only valid on new bookings.  Please discuss with your trip planner about applicable dates and cabin types.
Applies to select departures

Per person starting at
$15,890 2-3 travelers
Rates are subject to change without notice. Book early to get the best rate.
Single Balcony
Queen-size bed, full-size private bathroom with a full set of amenities, sliding glass doors open to private balcony, satellite TV and DVD player, complimentary WiFi Size: 250 sq. ft., including balcony
Standard Balcony
King-size bed, full-size private bathroom with a full set of amenities, sliding glass doors open to a private balcony, sitting area, writing desk, satellite TV and DVD player, complimentary WiFi Size: 275 sq. ft., including balcony
Deluxe Balcony
King-size bed, full-size private bathroom with a full set of amenities, sliding glass doors open to private balcony, sitting area, writing desk, satellite TV and DVD player, complimentary WiFi, Size: 316 sq. ft., including balcony
Premium Balcony
King-size bed that can convert to two twin beds, full-size private bathroom with a full set of amenities, sliding glass doors open to private balcony, sitting area, writing desk, satellite TV and DVD player, complimentary WiFi. Located on the top deck, these spacious staterooms feature commanding views of the passing river landscapes. Size: 350 sq. ft., including balcony
Veranda Suite
King-size bed that can convert to two twin beds, full-size private bathroom with a full set of amenities, large living area, sliding glass doors open to private balcony, satellite TV and DVD player, complimentary WiFi. Size: 405 sq. ft., including balcony
Grand Suite
Grand Suite
King-size bed, floor-to-ceiling glass windows offering 270-degree panoramic views, large balcony, private dining area, full-size private bathroom with a full set of amenities, satellite TV and DVD player, complimentary WiFi, individual climate control. Each Grand Suite features a separate bedroom and living area, ideal for gathering with family and friends after an invigorating day of exploration. Size: 650 sq. ft., including balcony
Included
  • 22 Breakfasts, 20 Lunches, 21 Dinners
  • 22 Nights Accommodations
  • Accommodations as listed
  • Ground transportation as listed
  • Activities as listed
  • Meals as listed
  • Access to a 24-7 Emergency line while traveling
  • Snacks
  • Onboard Entertainment 
  • Onboard gratuities
  • Port charges and fees
  • Complimentary cocktail parties
  • Dining service
  • WiFi provided by Starlink
  • Wine and beer service each afternoon and evening
  • Resident historians and experts who lead discussions and enlighten as you sail
  • Personalized experiences with a dedicated guest programs staff
Excluded
  • Travel Insurance
  • Personal Expenses
  • Flight costs (please request a quote)
  • Additional excursions during free time
  • Fuel and transportation surcharges (when applicable)
  • Premium and Signature shore excursions

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The trip was terrific with great planning on your part. Most of the adventures were not mainstream and somewhat off the beaten path which made it especially enjoyable!! We felt taken care of and you all were readily available to respond to questions and issues. I would highly recommend your company and friends have already expressed interest based on our pictures and excitement.
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