Top Mississippi River Trips & Tours

from $3,630

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Historic Mississippi River Cruise

New Orleans Roundtrip - 8 Day Itinerary aboard American Heritage

• Experience Natchez’s beauty
• Visit historic Civil War sites
• Discover Oak Alley's historic charm
• Visit charming ports and cities

Starts / Ends

New Orleans / New Orleans

Activity Level

Variable

The American Heritage hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.

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from $5,275

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Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Symphony

• Admire the diversity of New Orleans
• Discover the cultures of the delta
• Learn the history of Vicksburg
• Enjoy the music of Memphis

Starts / Ends

Memphis / New Orleans

Activity Level

Variable

Experience a 9-day cruise aboard American Symphony from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

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from $4,915

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Music Cities Cruise

Memphis, TN to Nashville, TN - 9 Day Itinerary aboard American Symphony

• Discover Memphis live music scene
• Witness scenic cliffs
• See Nashville’s iconic Hall of Fame
• Walk at Clarksville’s streets

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Memphis / Nashville

Activity Level

Variable

Travel from Memphis to Nashville on a 9-day river cruise aboard American Symphony. Enjoy live onboard music, explore cities like Paducah and Clarksville, and visit landmarks such as Fort Donelson and the Grand Ole Opry. Experience music, history, and river scenery through curated excursions and onboard activities.

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from $5,635

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Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Melody

• Explore the culture of St. Louis
• See Mark Twain's hometown, Hannibal
• Experience wildlife and nature
• Admire local artwork in Red Wing

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St. Louis / Red Wing

Activity Level

Variable

Explore the Upper Mississippi River on this 9-day cruise from St. Louis to Minneapolis aboard the American Melody. Begin in St. Louis, Missouri, and travel through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.

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from $4,610

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Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Heritage

• Explore the culture of St. Louis
• See Mark Twain's hometown, Hannibal
• Witness wildlife and nature
• Admire local artwork in Red Wing

Starts / Ends

St. Louis / St. Paul

Activity Level

Variable

Explore the Upper Mississippi River aboard the American Heritage on this 9-day cruise from St. Louis to Minneapolis. Begin in St. Louis, Missouri, and travel through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns and take in the diverse scenery.

Cruise Details

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from $5,635

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Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Symphony

• Explore Mark Twain’s hometown
• Cruise through historic towns
• Explore St. Paul's grand mansions
• Visit National River Museum

Starts / Ends

St. Louis / Red Wing

Activity Level

Variable

Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Symphony. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.

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from $15,890

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Complete Mississippi River

New Orleans - St. Paul - 23 Day Itinerary aboard American Melody

• Explore Natchez's Grand Homes
• Visit Oak Alley
• Delve into Baton Rouge's history
• Unravel Vicksburg's Civil War

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New Orleans / St. Paul

Activity Level

Variable

Discover the Mighty Mississippi on a 23-day cruise covering 10 states aboard American Melody. Immerse in history, culture, and cuisine from New Orleans to Minneapolis, exploring charming ports along the way.

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from $4,610

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Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Heritage

• Admire the diversity of New Orleans
• Discover the cultures of the delta
• Learn the history of Vicksburg
• Enjoy the music of Memphis

Starts / Ends

Memphis / New Orleans

Activity Level

Variable

Experience a 9-day cruise aboard American Heritage from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

Cruise Details

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from $5,275

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EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Melody

• Admire the diversity of New Orleans
• Visit Myrtles' haunted estate
• Learn the history of Vicksburg
• Enjoy the music of Memphis

Starts / Ends

Memphis / New Orleans

Activities

Cooking Classes

Activity Level

Variable

Experience a 9-day cruise aboard American Melody from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

Cruise Details

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from $4,255

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Historic Mississippi River Cruise

New Orleans Roundtrip - 8 Day Itinerary aboard American Melody

• Explore the antebellum of Natchez
• Visit historic Civil War sites
• Discover Oak Alley's historic charm
• Visit charming ports and cities

Starts / Ends

New Orleans / New Orleans

Activity Level

Variable

The American Melody hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.

Cruise Details

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from $4,610

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EXPLORE

Lower Mississippi River Cruise

New Orleans - Memphis - 9 Day Itinerary aboard American Heritage

• Admire the diversity of New Orleans
• Discover the cultures of the delta
• Learn the history of Vicksburg
• Enjoy the music of Memphis

Starts / Ends

New Orleans / Memphis

Activity Level

Variable

Experience a 9-day cruise aboard American Heritage from New Orleans to Memphis, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

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from $12,620

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Grand Heartland Cruise

Minnesota - Louisiana - 16 Day Itinerary aboard American Serenade

• Visit mansions and art galleries
• See the Gateway Arch and St. Louis
• Visit Natchez’s antebellum homes
• Experience Memphis' musical legacy

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St. Paul / New Orleans

Activity Level

Variable

Embark on a 16-day Mississippi River cruise from Minnesota to Louisiana aboard American Serenade, exploring St. Paul to New Orleans with stops in La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, and Natchez. Enjoy onboard activities, stunning scenery, and experiences like the Mark Twain Boyhood Home and more.

Cruise Details

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from $4,295

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Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Splendor

• Admire the diversity of New Orleans
• Discover the cultures of the delta
• Learn the history of Vicksburg
• Enjoy the music of Memphis

Starts / Ends

Memphis / New Orleans

Activity Level

Variable

Experience a 9-day cruise aboard American Heritage from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

Cruise Details

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from $7,275

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Mississippi Explorer

New Orleans - Memphis - 12 Day Itinerary aboard American Symphony

• Explore Natchez's Grand Homes
• Visit Oak Alley
• Delve into Baton Rouge's history
• Unravel Vicksburg's Civil War

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New Orleans / Memphis

Activity Level

Variable

Set sail on a 12-day Mississippi river cruise aboard the American Symphony, from New Orleans to Memphis, visiting Southern landmarks like Oak Alley, Houmas House, and Vicksburg National Military Park. Explore Baton Rouge's history, Natchez's antebellum homes, and Cleveland's musical heritage.

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from $9,240

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Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody

• Explore historic Marietta, Ohio
• Explore Maysville’s Railroad
• Visit Louisville’s Churchill Downs
• Tour Paducah’s wall murals

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Pittsburgh / St. Louis

Activity Level

Variable

Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.

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from $6,360

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Mississippi River Gateway Cruise

New Orleans to Louisville - 12 Day Itinerary aboard American Heritage

• Explore Oak Alley Plantation
• See Paducah wall murals
• Explore Sun Studio
• Visit Elvis Presley’s estate

Starts / Ends

New Orleans / Louisville

Activity Level

Variable

Embark on a 12-day Mississippi River cruise from New Orleans to Louisville aboard American Heritage. Explore iconic sites like Oak Alley, Vicksburg, and Memphis. Enjoy enriching excursions, Civil War history, live music, and Southern cuisine.

Cruise Details

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from $5,635

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Upper Mississippi River

St. Paul, MN - St. Louis, MO - 9 Day Itinerary aboard American Serenade

• Tour historic Summit Avenue
• Explore Dubuque River Museum
• Experience John Deere Pavilion
• Visit Mark Twain’s boyhood home

Starts / Ends

St. Paul / St. Louis

Activities

Wine Tasting, Biking, Wildlife Viewing

Activity Level

Variable

Set sail for 9 days aboard American Serenade from St. Paul to St. Louis. Walk through historic Summit Avenue, admire La Crosse from Grandad’s Bluff, explore Dubuque’s River Museum, and discover Mark Twain’s legacy in Hannibal. Experience curated onboard programs, live music, and the beauty of the Upper Mississippi’s diverse wildlife.

Cruise Details

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from $5,275

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Lower Mississippi River Cruise

New Orleans - Memphis - 9 Day Itinerary aboard American Melody

• Explore New Orleans lively culture
• Discover Oak Alley with landscapes
• Uncover St Francisville stories
• Engage Cleveland music heritage

Starts / Ends

New Orleans / Memphis

Activities

Urban Exploration, Archaeological Site Visits, Village Visits, Local Market Visits

Activity Level

Variable

Embark on a 9-day cruise from New Orleans to Memphis aboard American Melody, exploring Southern culture and history with local guides. Enjoy enriching excursions, gourmet meals, daily cocktails, and captivating shows at historic sites like Vicksburg and Natchez.

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