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Mississippi River Cruises

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Mississippi River
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Experience the mighty Mississippi River on one of Adventure Life's 16 River Cruises for 2025. Navigate through the heart of America on cruises ranging from 8 to 23 days days, immersing yourself in the cultural tapestry of the region. From the vibrant music scene in New Orleans to the historic charm of Natchez, these cruises offer a blend of luxury and Southern hospitality that will leave you enchanted. Explore charming river towns, indulge in delicious Southern cuisine, and witness the diverse wildlife along the riverbanks. Join us on a trip to discover the iconic Mississippi River and its unparalleled beauty. Contact one of our award-winning river cruise experts for help planning your next seamless trip.
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    • Mississippi River
Visit historic Memphis, Tennessee
from $5,275
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Symphony
Starts / Ends
Memphis / New Orleans
Activity Level
Variable
Experience a 9-day cruise aboard American Symphony from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Cruise Details
0
Visit Louisiana's capital city of Baton Rouge
from $3,630
Savings
EXPLORE

Historic Mississippi River Cruise

New Orleans Roundtrip - 8 Day Itinerary aboard American Heritage
Starts / Ends
New Orleans / New Orleans
Activity Level
Variable
The American Heritage hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.
  • Experience Natchez’s beauty
  • Visit historic Civil War sites
  • Discover Oak Alley's historic charm
  • Visit charming ports and cities
Cruise Details
0
Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $12,620
Savings
EXPLORE

Grand Heartland Cruise

Minnesota - Louisiana - 16 Day Itinerary aboard American Serenade
Starts / Ends
St. Paul / New Orleans
Activities
Wine Tasting, Wildlife Viewing, Biking
Activity Level
Variable
Embark on a 16-day Mississippi River cruise from Minnesota to Louisiana aboard American Serenade, exploring St. Paul to New Orleans with stops in La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, and Natchez. Enjoy onboard activities, stunning scenery, and experiences like the Mark Twain Boyhood Home and more.
  • Visit mansions and art galleries
  • See the Gateway Arch and St. Louis
  • Visit Natchez’s antebellum homes
  • Experience Memphis' musical legacy
Cruise Details
0
Wander through the historic French Quarter
from $3,499
EXPLORE

New Orleans & Southern Charms

8 Day Itinerary aboard Viking Mississippi
Starts / Ends
New Orleans / New Orleans
Activities
Festival Visits
Activity Level
Variable
Explore the highlights of the Mississippi River on this 8-day cruise roundtrip from New Orleans aboard Viking Mississippi. Discover port cities such as St. Francisville, Darrow, Baton Rouge, Natchez, and Vicksburg to experience the diverse culture and rich history of the lower Mississippi region.
  • Enjoy Cajun and Creole cuisine
  • Indulge in New Orleans' music
  • Learn the history of Vicksburg
  • See the historic homes of Natchez
Cruise Details
0
View the iconic arch when you visit St. Louis, gateway to the west
from $12,999
EXPLORE

America’s Great River

St. Paul to New Orleans - 15 Day Itinerary aboard Viking Mississippi
Starts / Ends
St. Paul / New Orleans
Activity Level
Variable
Cruise America's great river on this 15-day itinerary aboard Viking Mississippi. Journey from St. Paul, Minnesota to New Orleans, Louisiana and explore highlights of the mighty Mississippi River. Along the way, visit historic ports such as St. Louis, Memphis, Baton Rouge, and more.
  • Explore St. Louis' arts scene
  • Enjoy American music styles
  • Learn Civil War history
  • Experience New Orleans' culture
  • Visit the Quad Cities
Cruise Details
0
Vicksburg Battlefield overlooking the Mississippi River
from $3,999
EXPLORE

Mississippi Delta Explorer

New Orleans - Memphis - 8 Day Itinerary aboard Viking Mississippi
Starts / Ends
New Orleans / Memphis
Activities
Urban Exploration, Archaeological Site Visits, Village Visits
Activity Level
Variable
On this 8-day Mississippi Delta Explorer from New Orleans to Memphis aboard the Viking Mississippi, visit historic towns like Darrow, Natchez, and Vicksburg. Enjoy Cajun and Creole cuisine, Memphis barbecue, and explore the South’s rich history, culture, and music.
  • Explore Darrow
  • Visit Natchez historic sites
  • Learn the history of Vicksburg
  • Culinary adventure of Mississippi
  • Know the history of rock 'n' roll
  • American South's Cultural Heritage
Cruise Details
0
Mississippi River, St. Paul Minnesota
from $5,635
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Melody
Starts / Ends
St. Louis / Red Wing
Activity Level
Variable
Explore the Upper Mississippi River on this 9-day cruise from St. Louis to Minneapolis aboard the American Melody. Begin in St. Louis, Missouri, and travel through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Experience wildlife and nature
  • Admire local artwork in Red Wing
Cruise Details
0
Mississippi River, St. Paul Minnesota
from $4,610
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Heritage
Starts / Ends
St. Louis / St. Paul
Activity Level
Variable
Explore the Upper Mississippi River aboard the American Heritage on this 9-day cruise from St. Louis to Minneapolis. Begin in St. Louis, Missouri, and travel through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns and take in the diverse scenery.
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Witness wildlife and nature
  • Admire local artwork in Red Wing
Cruise Details
0
Visit Louisiana's capital city of Baton Rouge
from $4,295
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Splendor
Starts / Ends
Memphis / New Orleans
Activities
Local Market Visits
Activity Level
Variable
Experience a 9-day cruise aboard American Heritage from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Cruise Details
0
Visit historic Minneapolis
from $15,890
Savings
EXPLORE

Complete Mississippi River

New Orleans - St. Paul - 23 Day Itinerary aboard American Melody
Starts / Ends
New Orleans / St. Paul
Activity Level
Variable
Discover the Mighty Mississippi on a 23-day cruise covering 10 states aboard American Melody. Immerse in history, culture, and cuisine from New Orleans to Minneapolis, exploring charming ports along the way.
  • Explore Natchez's Grand Homes
  • Visit Oak Alley
  • Delve into Baton Rouge's history
  • Unravel Vicksburg's Civil War
Cruise Details
0
Memphis, Tennesse, USA downtown cityscape at dusk over Beale Street
from $5,275
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Melody
Starts / Ends
Memphis / New Orleans
Activities
Cooking Classes
Activity Level
Variable
Experience a 9-day cruise aboard American Melody from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.
  • Admire the diversity of New Orleans
  • Visit Myrtles' haunted estate
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Cruise Details
0
View monuments from the Civil War in Mississippi
from $4,610
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Heritage
Starts / Ends
Memphis / New Orleans
Activity Level
Variable
Experience a 9-day cruise aboard American Heritage from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Cruise Details
0
Vicksburg Battlefield overlooking the Mississippi River
from $4,610
Savings
EXPLORE

Lower Mississippi River Cruise

New Orleans - Memphis - 9 Day Itinerary aboard American Heritage
Starts / Ends
New Orleans / Memphis
Activity Level
Variable
Experience a 9-day cruise aboard American Heritage from New Orleans to Memphis, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Cruise Details
0
Explore historic New Orleans
from $4,255
Savings
EXPLORE

Historic Mississippi River Cruise

New Orleans Roundtrip - 8 Day Itinerary aboard American Melody
Starts / Ends
New Orleans / New Orleans
Activity Level
Variable
The American Melody hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.
  • Explore the antebellum of Natchez
  • Visit historic Civil War sites
  • Discover Oak Alley's historic charm
  • Visit charming ports and cities
Cruise Details
0
Explore beautiful Nashville
from $4,915
Savings
EXPLORE

Music Cities Cruise

Memphis, TN to Nashville, TN - 9 Day Itinerary aboard American Symphony
Starts / Ends
Memphis / Nashville
Activity Level
Variable
Set sail on a 9-day cruise on the American Symphony from Memphis to Nashville, traversing the Mississippi, Ohio, and Cumberland rivers—Immerse in local music, nightly entertainment, and Southern cuisine amid America's heartland's scenic beauty.
  • Explore Memphis
  • Discover Paducah
  • Experience Lake Barkley
  • Enjoy Nashville
Cruise Details
0
Mississippi River, St. Paul Minnesota
from $5,635
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Symphony
Starts / Ends
St. Louis / Red Wing
Activity Level
Variable
Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Symphony. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
  • Explore Mark Twain’s hometown
  • Cruise through historic towns
  • Explore St. Paul's grand mansions
  • Visit National River Museum
Cruise Details
0
1-16 of 16 Results
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TrustScore 4.8 | 544 reviews
TrustScore 4.8 of 5
total score
Based on 544 reviews on
review score
2 months ago
Betty was extremely helpful and friendly! I have never traveled by long boat and was nervous about the options and the experience. Betty listened carefully to my wants and needs and presented exactly what my sister and I hoped for! I couldn’t have asked a more pleasant experience - I am so excited about our trip!!
Jan Struck

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