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Missouri Cultural Cruises

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Explore the heart of Missouri's vibrant culture with Adventure Life's 4 meticulously designed cultural tours for 2025. From the music of Memphis to the historic handicrafts of St. Louis, set off on a journey that promises a wealth of eye-opening experiences and memories. Discover the seismic wonders of New Madrid, admire the arts scene of St. Louis, and delve into the Civil War history along the mighty Mississippi River. With activities ranging from urban exploration to village visits, these tours offer a relaxed yet immersive way to experience the soul of the American Midwest. Join us on a trip filled with artistic inspiration, cultural discoveries, and warm hospitality. Contact one of Adventure Life's tour specialists for help planning your next seamless trip.
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View the iconic arch when you visit St. Louis, gateway to the west
from $12,999
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America’s Great River

St. Paul to New Orleans - 15 Day Itinerary aboard Viking Mississippi
  • Explore St. Louis' arts scene
  • Enjoy American music styles
  • Learn Civil War history
  • Experience New Orleans' culture
  • Visit the Quad Cities
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St. Paul / New Orleans
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Cruise America's great river on this 15-day itinerary aboard Viking Mississippi. Journey from St. Paul, Minnesota to New Orleans, Louisiana and explore highlights of the mighty Mississippi River. Along the way, visit historic ports such as St. Louis, Memphis, Baton Rouge, and more.
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Mississippi River, St. Paul Minnesota
from $5,545
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Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Melody
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Witness wildlife and nature
  • Admire local artwork in Red Wing
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St. Louis / Red Wing
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Variable
Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Melody. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
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Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $11,755
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Grand Heartland Cruise

Minnesota - Louisiana - 16 Day Itinerary aboard American Serenade
  • Visit mansions and art galleries
  • See the Gateway Arch and St. Louis
  • Visit Natchez’s antebellum homes
  • Experience Memphis' musical legacy
Starts / Ends
St. Paul / New Orleans
Activities
Village Visits
Activity Level
Variable
Embark on a 16-day Mississippi River cruise from Minnesota to Louisiana aboard American Serenade, exploring St. Paul to New Orleans with stops in La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, and Natchez. Enjoy onboard activities, stunning scenery, and experiences like the Mark Twain Boyhood Home and more.
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Mississippi River, St. Paul Minnesota
from $4,530
Savings
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Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Heritage
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Witness wildlife and nature
  • Admire local artwork in Red Wing
Starts / Ends
St. Louis / Red Wing
Activities
Archaeological Site Visits, Urban Exploration
Activity Level
Variable
Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Heritage. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
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