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Bridge and city lights in Ohio River

Ohio River Trips with Village Visits

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Explore remote villages on one of the below 5 unique Ohio River cultural experiences for 2026 or 2027. Visit the local village, meet the people, experience local cuisine with a local English speaking guide on your own private tour or small group guided tour. Discover unique local cultures on trips that include activities like Urban Exploration, Archaeological Site Visits, Wildlife Viewing, Cooking Classes, and Local Market Visits and cost from $5,499 for experiences of 8 to 16 days. Tell us about your ideal Ohio River cultural trip and our Ohio River experts will help you plan every detail of your next trip.

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    • Ohio River
View the iconic arch when you visit St. Louis, gateway to the west
from $9,920
Savings
EXPLORE

Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody
  • Explore historic Marietta, Ohio
  • Explore Maysville’s Railroad
  • Visit Louisville’s Churchill Downs
  • Tour Paducah’s wall murals
Starts / Ends
Pittsburgh / St. Louis
Activity Level
Variable
Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.
Cruise Details
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Visit historic and hilly Pittsburgh
from $9,920
Savings
EXPLORE

Grand Ohio River Cruise

St. Louis to Pittsburgh - 16 Day Itinerary aboard American Melody
  • Explore St. Louis history
  • Discover Paducah river heritage
  • Explore Louisville traditions
  • Discover Cincinnati heritage
Starts / Ends
St. Louis / Pittsburgh
Activity Level
Variable
Explore a 16-day Mississippi and Ohio River cruise from St. Louis to Pittsburgh aboard American Melody. Visit Paducah, Henderson, Evansville, Louisville, Madison, Cincinnati, Maysville, and Marietta, with time for museums, historic districts, Underground Railroad sites, regional art, river heritage, and American history. Discover local history.
Cruise Details
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Explore beautiful Nashville
from $5,499
EXPLORE

Nashville, Memphis & the Cumberland

Memphis to Nashville - 8 Day Itinerary aboard Viking Mississippi
  • Discover Memphis blues roots
  • See Paducah murals
  • Walk historic Clarksville streets
  • Cruise Tennessee River scenery
Starts / Ends
Memphis / Nashville
Activities
Wine Tasting
Activity Level
Variable
Take an 8-day Viking Mississippi cruise through Memphis, Cape Girardeau, Paducah, Clarksville, and Nashville. Visit key cultural and historical sites, from music landmarks to Civil War history and regional museums.
Cruise Details
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Visit historic Memphis, Tennessee
from $9,999
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The Big Easy to the Gateway City

New Orleans - St. Louis - 15 Day Itinerary aboard Viking Mississippi
  • Explore New Orleans French Quarter
  • Tour Darrow spectacular gardens
  • Enjoy Memphis rich history
  • Discover Natchez historic estates
Starts / Ends
New Orleans / Alton
Activity Level
Variable
Discover early 19th-century life and Civil War history on a 15-day cruise aboard the Viking Mississippi. Visit grand plantations, memorials, and key sites of the Civil Rights Movement while enjoying regional traditions along the iconic river.
Cruise Details
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Explore Nashville
from $11,270
Savings
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Mississippi and Cumberland Rivers Cruise

New Orleans to Nashville - 16 Day Itinerary aboard American Symphony
  • Cruise Mississippi and Cumberland
  • Explore Vicksburg's battlefields
  • Trace jazz, blues & country roots
  • Wander at the Oak Alley Plantation
Starts / Ends
New Orleans / Nashville
Activities
Urban Exploration, Wildlife Viewing, Village Visits, Archaeological Site Visits, Local Market Visits, Cooking Classes
Activity Level
Variable
Embark on a 16-day cruise linking two rivers, the Mississippi and Cumberland, between New Orleans and Nashville aboard American Symphony. Visit Civil War battlefields, antebellum estates, and the birthplaces of jazz, blues, and country music.
Cruise Details
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Bridge and city lights in Ohio River
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