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Bridge and city lights in Ohio River

Ohio River Wildlife Viewing Trips & Safaris

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Explore the amazing wildlife of Ohio River on one of these 5 tours to Paducah, Cincinnati, Henderson, Louisville, and Madison in 2026-2027. Prices for a wildlife viewing trip in Ohio River range from $5,499 to $19,795 for a trip of 8 to 16 days. Choose one of the below 5 Ohio River wildlife safari tours and make it your own unique experience with the help of one of Adventure Life's expert Ohio River trip planners.
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    • Ohio River
View the iconic arch when you visit St. Louis, gateway to the west
from $9,920
Savings
EXPLORE

Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody
  • Explore historic Marietta, Ohio
  • Explore Maysville’s Railroad
  • Visit Louisville’s Churchill Downs
  • Tour Paducah’s wall murals
Starts / Ends
Pittsburgh / St. Louis
Activities
Village Visits
Activity Level
Variable
Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.
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Visit historic and hilly Pittsburgh
from $9,920
Savings
EXPLORE

Grand Ohio River Cruise

St. Louis to Pittsburgh - 16 Day Itinerary aboard American Melody
  • Explore St. Louis history
  • Discover Paducah river heritage
  • Explore Louisville traditions
  • Discover Cincinnati heritage
Starts / Ends
St. Louis / Pittsburgh
Activities
Urban Exploration, Wildlife Viewing, Archaeological Site Visits
Activity Level
Variable
Explore a 16-day Mississippi and Ohio River cruise from St. Louis to Pittsburgh aboard American Melody. Visit Paducah, Henderson, Evansville, Louisville, Madison, Cincinnati, Maysville, and Marietta, with time for museums, historic districts, Underground Railroad sites, regional art, river heritage, and American history. Discover local history.
Cruise Details
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Explore beautiful Nashville
from $5,499
EXPLORE

Nashville, Memphis & the Cumberland

Memphis to Nashville - 8 Day Itinerary aboard Viking Mississippi
  • Discover Memphis blues roots
  • See Paducah murals
  • Walk historic Clarksville streets
  • Cruise Tennessee River scenery
Starts / Ends
Memphis / Nashville
Activities
Wine Tasting
Activity Level
Variable
Take an 8-day Viking Mississippi cruise through Memphis, Cape Girardeau, Paducah, Clarksville, and Nashville. Visit key cultural and historical sites, from music landmarks to Civil War history and regional museums.
Cruise Details
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View monuments from the Civil War in Mississippi
from $9,850
EXPLORE

Mississippi & Tennessee Rivers Cruise

Huntsville - New Orleans - 16 Day Itinerary aboard American Heritage
  • Explore Huntsville Space History
  • Discover Florence Music Heritage
  • Explore Vicksburg Civil War Sites
  • Discover New Orleans Culture
Starts / Ends
Florence / New Orleans
Activities
Cooking Classes
Activity Level
Variable
Explore a 16-day river cruise from Huntsville to New Orleans aboard American Heritage, following the Tennessee and Mississippi Rivers through Florence, Savannah, Paducah, Memphis, Vicksburg, Natchez, St. Francisville, Baton Rouge and Oak Alley, with historic sites, museums, music, Civil War history and Southern culture and historic cultural sites.
Cruise Details
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Visit Louisiana's capital city of Baton Rouge
from $8,670
Savings
EXPLORE

Mississippi & Tennessee Rivers Cruise

New Orleans to Huntsville - 16 Day Itinerary aboard American Heritage
  • Explore New Orleans History
  • Visit Oak Alley Estate
  • Explore Vicksburg Civil War
  • Explore Memphis Music Heritage
Starts / Ends
New Orleans / Florence
Activity Level
Variable
Explore New Orleans to Huntsville on a 16-day Mississippi River cruise aboard American Heritage. Visit historic estates, Civil War sites, music landmarks, museums, arts districts, and river towns while following the Mississippi and Tennessee rivers through Louisiana, Mississippi, Tennessee, Kentucky, and Alabama. Experience local traditions.
Cruise Details
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Bridge and city lights in Ohio River
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