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Explore the coastlines of the Great Lakes

Ohio River Cruises

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Discover the enchanting beauty and charm of Ohio on a river cruise with Adventure Life. With 1 unique river cruises available in 2025, ranging from 16 days, you can sail through historic towns, lush landscapes, and vibrant cities. Navigate the waters of the Ohio River and its tributaries, immersing yourself in the rich cultural heritage of the region. Discover picturesque villages, indulge in delicious local cuisine, and witness diverse wildlife along the riverbanks. From wine tasting to wildlife viewing, there are plenty of activities to choose from on these river cruises. Join us on a trip to Ohio in 2025 and contact one of our river cruise experts for help planning your next seamless trip.
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View the iconic arch when you visit St. Louis, gateway to the west
from $9,240
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Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody
  • Explore historic Marietta, Ohio
  • Explore Maysville’s Railroad
  • Visit Louisville’s Churchill Downs
  • Tour Paducah’s wall murals
Starts / Ends
Pittsburgh / St. Louis
Activities
Wildlife Viewing, Village Visits, Urban Exploration, Archaeological Site Visits
Activity Level
Variable
Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.
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