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Coast of Ortigia island at city of Syracuse

Syracuse Mediterranean Cruises & Tours

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Board a small ship cruise from the gorgeous city of Syracuse, Italy. Located on the shore of the Southern Mediterranean Italy coast, this city has a population of more than 121,000 inhabitants. Contact our travel specialists to start planning your ideal trip with Adventure Life to Syracuse today!

10 Best Syracuse Mediterranean Cruises & Tours for 2025-2026

Coast of Ortigia island at city of Syracuse

Sicily & Greece

9 Days from $2,590
Set sail on a 9-day cruise with Star Clipper, exploring Greece, Sicily, and Malta. Discover ancient sites, stunning landscapes, and cultural gems from Athens to Valletta while enjoying the charm of your ship.
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Cruise into charming Sicily

Amalfi & Sicily

8 Days from $2,460
Set sail on an 8-day cruise aboard the Royal Clipper, exploring Italy and Sicily with stops in Civitavecchia, Sorrento, Amalfi, Taormina, and Syracuse. Enjoy volcanic views at the Aeolian Islands and optional excursions to Pompeii while experiencing Mediterranean beauty and history.
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View of Valletta

Sicily & Greece

6 Days from $1,710
Embark on a 6-day cruise from Valletta to Athens aboard the Star Flyer, exploring Sicily's archaeological wonders and Greece's historic sites. Experience relaxation at sea and visit ancient locales like Pilos and Monemvasia before concluding your journey in Piraeus.
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Explore Sibenik on the Dalmatian Coast

Italy, Montenegro & Croatia

12 Days from $3,870
Set sail on a 12-day Royal Clipper cruise through the Mediterranean, visiting stunning destinations like Venice, Dubrovnik, and Syracuse. Experience rich history and culture while enjoying scenic views and a relaxing day at sea before concluding in Civitavecchia, near Rome.
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Explore historic Bonifacio atop the cliffs of Corsica

Mediterranean Island Voyage: Sicily, Sardinia, Corsica, and Elba – with Smithsonian Journeys

8 Days from $7,790
Explore the heart of the Mediterranean on this 8-day Mediterranean Island Cruise with Smithsonian Journeys from Valletta to Nice aboard Le Bougainville. Discover Sicily, Sardinia, Corsica, and Elba's historical civilizations that left mark on these islands' language, cuisine, art, and architecture.
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Blue hour over the city in the shadow of Mount Etna

Mediterranean Serenade

8 Days from $3,699
Embark on an 8-day cruise to and from Malta aboard the Variety Voyager. Discover the UNESCO World Heritage Ggantija temples on Gozo Island and Lipari in Sicily. Ascend Mount Etna and explore iconic "The Godfather" filming locations.
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Tour the charming city of Valletta, Malta.

A Circumnavigation of Sicily with Smithsonian Journeys

9 Days from $9,450
During this 9-day cruise around Sicily aboard the new luxury expedition ship Le Bougainville, you'll be able to explore mythical places at the crossroads of Eastern and Western civilizations. Discover Sicily's most beautiful historic cities and ancient sites.
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Stop in beautiful Malta

Island Odyssey: Malta, Sicily & the Greek Isles

8 Days from $23,540
Embark on an 8-day cruise aboard Scenic Eclipse II, starting in Valletta, Malta, and visiting historic Syracuse, Nafplion, and Mykonos. Experience the cultural richness, history, and stunning coastal beauty of the Mediterranean in style and comfort.
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Blue hour over the city in the shadow of Mount Etna

Dreaming of Sicilian Sun

8 Days from $12,295
Sail away on Sea Cloud II for an 8-day cruise and discover a historically significant site with ancient temple complexes and UNESCO World Heritage status. Walk Valletta's streets lined with golden facades, then explore Trapani's medieval town and Palermo's vibrant mix of Arab, Swabian, and Norman influences.
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Coast of Ortigia island at city of Syracuse

Ancient Jewels of the Mediterranean

8 Days from $5,510
Embark on an 8-day adventure on L’Austral from Athens to the Maltese coast. Enjoy excursions at each port, including visits to Hydra's monuments, Paros, and Galaxidi. In southern Italy, discover Gallipoli's Greek heritage, Taormina's ancient theatre, and Ortygia's historic streets. The cruise concludes in Valletta, the capital of Malta.
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