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Explore these 13 top Louisville cruises for 2022 and 2023. Some of the most popular activities on our Louisville trips include river cruises, cruises, cultural, village visits, and classic. Discover Louisville with your expert local English-speaking guides who will show you the hot spots and the off-the-beaten-path hidden gems. We work with only the best small ships that carry under 500 fortunate guests, and we can give you unbiased advice to match you with the perfect ship and perfect cruise for your next vacation. Our Louisville cruises start from $1,999 for cruises of 9 days. Contact one of Adventure Life's Louisville cruise specialists for help planning a seamless trip.
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    • Louisville
$2,299
EXPLORE

Louisville to St. Louis

9 Day Itinerary aboard American Countess
  • Taste famous Kentucky bourbon
  • Enjoy the music of Owensboro
  • Admire historic handicrafts
  • Explore vibrant St. Louis
Starts / Ends:
Louisville / St. Louis
Activities:
River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Board the American Countess riverboat and cruise through the heart of the American Midwest on this 9-day journey from Louisville, Kentucky to St. Louis, Missouri on the Ohio and Mississippi Rivers. Experience the laid-back, small-town hospitality of Kentucky ports such as Owensboro, where …
Cruise Details
0
$2,499
EXPLORE

Memphis to Louisville

9 Day Itinerary aboard American Duchess
  • Taste authentic local bourbon
  • Enjoy small-town hospitality
  • Listen to the music of Memphis
  • Explore artsy Louisville
Starts / Ends:
Memphis / Louisville
Activities:
River Cruises, Village Visits
Activity Level:
Relaxed
Board the American Duchess and join this delightful 9-day journey from Memphis, Tennessee to Louisville, Kentucky. Cruise the Mississippi and Ohio rivers and explore the cultural highlights of this region, from the musical traditions of Memphis and Owensboro to the artistic communities of Henderson …
Cruise Details
0
Sunset over the Cincinnati skyline
$2,799
EXPLORE

Louisville to Pittsburgh

9 Day Itinerary aboard American Duchess
  • Taste locally-distilled bourbon
  • Explore Cincinnati's lovely parks
  • Enjoy Maysville's opera scene
  • Learn the history of Point Pleasant
Starts / Ends:
Louisville / Pittsburgh
Activities:
Archaeological Site Visits, River Cruises, Village Visits
Activity Level:
Relaxed
Immerse yourself in the charm of small-town Americana culture on this 9-day Ohio River cruise aboard American Duchess. Set off from Louisville, Kentucky after experiencing the city's local culture, tasting locally-made bourbon, and wandering its quirky streets. Stroll through Cincinnati, Ohio, …
Cruise Details
0
Explore Pittsburgh
$2,299
EXPLORE

Louisville to Pittsburgh

9 Day Itinerary aboard American Countess
  • Taste locally-distilled bourbon
  • Explore Cincinnati's lovely parks
  • Enjoy Maysville's opera scene
  • Learn the history of Point Pleasant
Starts / Ends:
Louisville / Pittsburgh
Activities:
Archaeological Site Visits, River Cruises, Village Visits
Activity Level:
Relaxed
Immerse yourself in the charm of small-town Americana culture on this 9-day Ohio River cruise aboard American Countess. Set off from Louisville, Kentucky after experiencing the city's local culture, tasting locally-made bourbon, and wandering its quirky streets. Stroll through Cincinnati, Ohio, …
Cruise Details
0
$2,499
EXPLORE

American Culinary Experience

9 Day Itinerary aboard American Duchess
  • Explore vibrant St. Louis
  • Admire historic handicrafts
  • Enjoy the music of Owensboro
  • Taste famous Kentucky bourbon
Starts / Ends:
Louisville / St. Louis
Activities:
River Cruises, Village Visits
Activity Level:
Relaxed
Board the American Duchess riverboat and sail through the heart of the American Midwest on this 9-day adventure along the Ohio and Mississippi rivers from Louisville, Kentucky to St. Louis, Missouri. Discover the laid-back, small-town friendliness of Kentucky ports such as Owensboro, where …
Cruise Details
0
Explore beautiful Nashville
$2,499
Savings
EXPLORE

Nashville to Louisville

9 Day Itinerary aboard American Countess
  • Explore Nashville, Tennessee
  • Learn Civil War history in Dover
  • Visit the National Quilt Museum
  • Enjoy Henderson's art and cuisine
Starts / Ends:
Nashville / Louisville
Activities:
River Cruises
Activity Level:
Relaxed
Immerse yourself in the history, music, and culture of this unique part of the United States on a 9-day voyage along the Ohio and Cumberland rivers. Set sail from Nashville, which is widely regarded as the country music capital of the world. Discover Dover, Tennessee's laid-back small-town …
Cruise Details
0
Visit Cincinnati, Ohio
$2,499
EXPLORE

Cincinnati to Nashville

9 Day Itinerary aboard American Countess
  • Enjoy Cincinnati's cuisine
  • Admire Madison's architecture
  • Enjoy Louisville's art scene
  • Taste locally-distilled bourbon
Starts / Ends:
Cincinnati / Louisville
Activities:
River Cruises, Urban Exploration
Activity Level:
Relaxed
Join this 9-day cruise aboard American Countess. Cruise from Cincinnati to Nashville to experience the best of the Ohio River, exploring the scenic landscapes and exciting port cities along the way. The air practically crackles with excitement surrounding Kentucky’s favorite event, spilling …
Cruise Details
0
Sunset over the Cincinnati skyline
$2,399
EXPLORE

Pittsburgh to Louisville

9 Day Itinerary aboard American Countess
  • Experience unique Louisville
  • Explore Cincinnati's chili recipe
  • Enjoy art & live music in Maysville
  • Tour Marietta's museums
Starts / Ends:
Louisville / Pittsburgh
Activities:
Archaeological Site Visits, River Cruises, Village Visits
Activity Level:
Relaxed
Get to know the heart of the Ohio River on this 9-day voyage on the American Countess from Pittsburgh, Pennsylvania, to Louisville, Kentucky. Discover the history and culture of the small port cities that dot the river as you cruise. Visit Cincinnati, baseball's birthplace, and sample some of …
Cruise Details
0
$2,499
EXPLORE

Louisville to Clarksville

9 Day Itinerary aboard American Countess
  • Explore artsy Louisville
  • Enjoy authentic local bourbon
  • Learn about the region's history
  • Enjoy small-town hospitality
Starts / Ends:
Louisville / Clarksville
Activities:
River Cruises, Village Visits
Activity Level:
Relaxed
Board the American Countess and join this delightful 9-day journey from Louisville, Kentucky to Clarksville, Tennessee. Cruise the Ohio and Cumberland rivers and discover the region's cultural gems, from Brandenburg and Owensboro's musical traditions to Henderson and Paducah's artistic …
Cruise Details
0
$2,499
EXPLORE

Memphis to Louisville

9 Day Itinerary aboard American Countess
  • Taste authentic local bourbon.
  • Enjoy small-town hospitality
  • Listen to the music of Memphis
  • Explore artsy Louisville
Starts / Ends:
Memphis / Louisville
Activities:
River Cruises, Village Visits
Activity Level:
Relaxed
Board the American Countess and join this delightful 9-day journey from Memphis, Tennessee to Louisville, Kentucky. Cruise the Mississippi and Ohio rivers and explore the cultural highlights of this region, from the musical traditions of Memphis and Owensboro,to the artistic communities of …
Cruise Details
0
$2,299
EXPLORE

American Culinary Experience

Louisville to St. Louis - 9 Day Itinerary aboard American Countess
  • Explore vibrant St. Louis
  • Admire historic handicrafts
  • Enjoy the music of Owensboro
  • Taste famous Kentucky bourbon
Starts / Ends:
Louisville / St. Louis
Activities:
River Cruises, Village Visits
Activity Level:
Relaxed
On this 9-day voyage from Louisville, Kentucky to St. Louis, Missouri through the Ohio and Mississippi rivers, board the American Countess riverboat and travel through the heart of the American Midwest. Experience the laid-back, small-town hospitality of Kentucky ports such as Owensboro, where …
Cruise Details
0
Visit historic Memphis, Tennessee
$2,099
EXPLORE

Louisville to Memphis

9 Day Itinerary aboard American Countess
  • Experience the music of Memphis
  • Enjoy the music of Owensboro
  • Taste locally produced bourbon
  • Relax into a laid-back lifestyle
Starts / Ends:
Louisville / Memphis
Activities:
Adventure Options, River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Cruise the Mississippi and Ohio rivers aboard the American Countess on this 9-day cruise with a particular focus on the musical history and culture of this unique region. Board your ship in Louisville, Kentucky, where you can also get a taste of the famous locally-produced Kentucky bourbon. Visit a …
Cruise Details
0
Legendary Sun Studios in Memphis, TN
$1,999
EXPLORE

Louisville to Memphis

9 Day Itinerary aboard American Duchess
  • Experience the music of Memphis
  • Enjoy the music of Owensboro
  • Taste locally produced bourbon
  • Relax into a laid-back lifestyle
Starts / Ends:
Louisville / Memphis
Activities:
Adventure Options, River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Cruise the Mississippi and Ohio rivers aboard the American Duchess on this 9-day cruise with a particular focus on the musical history and culture of this unique region. Board your ship in Louisville, Kentucky, where you can also get a taste of famous locally-produced Kentucky bourbon. Visit a …
Cruise Details
0
1-13 of 13 Results

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