Have questions? We're here.

Ohio River Cruises

Travel made your way ™
Talk with an expert
Build your ideal United States trip. Call 1.406.541.2677
Start Planning My Trip
Talk with an expert
Experience the charm and beauty of the Ohio River with Adventure Life's selection of 3 diverse cruises for 2025. Join us on a cruise journey through the heartland of America, where you can immerse yourself in the rich cultural tapestry and picturesque landscapes of the region. From historic river towns to scenic countryside views, each moment offers a unique opportunity to discover the hidden gems along the Ohio River. Engage in cultural excursions, wildlife viewing, and local market visits, all while enjoying the comfort of small ship cruises. With activities like village visits and biking, this adventure offers a relaxed pace suitable for all travelers. Don't miss this chance to explore the historic waterway that played a vital role in shaping the Midwest. Contact one of Adventure Life's tour specialists for help planning your next seamless trip.
Filter (3 Results)
  • Start Date
    OR, More specific start
  • Length
    to
  • Price
    to
  • Activity Levels
  • Experiences
  • Activities
  • Ships
  • Destinations
    • Ohio River
Explore Pittsburgh
from $5,275
Savings
EXPLORE

Ohio River Cruise

Pittsburgh - Louisville - 9 Day Itinerary aboard American Melody
  • Explore Pittsburgh’s rich history
  • Visit historic Marietta, OH
  • Tour Cincinnati’s top sites
  • Experience Louisville Derby legacy
Starts / Ends
Pittsburgh / Louisville
Activities
Small Ship Sailing, Wine Tasting, Village Visits
Activity Level
Variable
Embark on a 9-day cruise along the Ohio River aboard the American Melody from Pittsburgh to Louisville. Discover historic towns and cultural landmarks while enjoying guided tours, historic excursions, and breathtaking river views as you cruise through America’s heartland.
Cruise Details
0
Explore beautiful Nashville
from $4,915
Savings
EXPLORE

Music Cities Cruise

Memphis, TN to Nashville, TN - 9 Day Itinerary aboard American Symphony
  • Explore Memphis
  • Discover Paducah
  • Experience Lake Barkley
  • Enjoy Nashville
Starts / Ends
Memphis / Nashville
Activity Level
Variable
Set sail on a 9-day cruise on the American Symphony from Memphis to Nashville, traversing the Mississippi, Ohio, and Cumberland rivers—Immerse in local music, nightly entertainment, and Southern cuisine amid America's heartland's scenic beauty.
Cruise Details
0
Explore beautiful Nashville
from $4,915
Savings
EXPLORE

Tennessee Rivers Cruise

Nashville to Chattanooga - 9 Day Itinerary aboard American Symphony
  • Explore Nashville’s music landmarks
  • Visit Paducah’s Quilt Museum
  • Walk historic Shiloh battlefield
  • Cruise through Appalachian scenery
Starts / Ends
Nashville / Chattanooga
Activities
Urban Exploration, Archaeological Site Visits, Local Market Visits
Activity Level
Variable
Set sail on a 9-day Tennessee Rivers Cruise from Nashville to Chattanooga aboard American Symphony. Relax with expert talks, regional cuisine, and comfortable accommodation while exploring the history, culture, and natural beauty of America’s heartland.
Cruise Details
0
1-3 of 3 Results
  • 1

United States Travel Guide

Top United States Travel Destinations

United States Trips by Departure Date

Top Experiences in United States

United States Trips by Duration

United States Trips by Activity

More Reasons

Why Travel With Adventure Life

All News

Recognized By

Rachel Brouwer employee head shot
Rachel B
Plan My Trip
We love travel, talk with an expert 1.800.344.6118