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Ohio River Cruises

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Experience the majestic beauty of the Ohio River on one of Adventure Life's 5 river cruises available for 2025. Navigating through the heart of the United States, these cruises offer a unique blend of history, culture, and natural wonders along the Ohio River. Sail past charming villages, lush landscapes, and iconic landmarks, immersing yourself in the rich heritage of the region. Explore quaint towns, partake in local food & wine experiences, and witness diverse wildlife while cruising this historic waterway. Whether you're interested in cultural excursions, wildlife viewing, or simply relaxing on deck, a river cruise along the Ohio River provides a perfect blend of activities for travelers of all interests. Don't miss the opportunity to discover the hidden gems of the Ohio River on an unforgettable journey with Adventure Life. Contact one of our award-winning river cruise experts for help planning your next seamless trip.
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    • Ohio River
View the iconic arch when you visit St. Louis, gateway to the west
from $9,240
Savings
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Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody
  • Explore historic Marietta, Ohio
  • Explore Maysville’s Railroad
  • Visit Louisville’s Churchill Downs
  • Tour Paducah’s wall murals
Starts / Ends
Pittsburgh / St. Louis
Activity Level
Variable
Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.
Cruise Details
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Visit historic Memphis, Tennessee
from $6,360
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Mississippi River Gateway Cruise

New Orleans to Louisville - 12 Day Itinerary aboard American Heritage
  • Explore Oak Alley Plantation
  • See Paducah wall murals
  • Explore Sun Studio
  • Visit Elvis Presley’s estate
Starts / Ends
New Orleans / Louisville
Activities
Archaeological Site Visits, Urban Exploration, Wildlife Viewing, Village Visits
Activity Level
Variable
Embark on a 12-day Mississippi River cruise from New Orleans to Louisville aboard American Heritage. Explore iconic sites like Oak Alley, Vicksburg, and Memphis. Enjoy enriching excursions, Civil War history, live music, and Southern cuisine.
Cruise Details
0
Explore beautiful Nashville
from $5,499
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Nashville, Memphis & the Cumberland

Memphis to Nashville - 8 Day Itinerary aboard Viking Mississippi
  • Discover Memphis blues roots
  • See Paducah murals
  • Walk historic Clarksville streets
  • Cruise Tennessee River scenery
Starts / Ends
Memphis / Nashville
Activities
Wine Tasting
Activity Level
Variable
Take an 8-day Viking Mississippi cruise through Memphis, Cape Girardeau, Paducah, Clarksville, and Nashville. Visit key cultural and historical sites, from music landmarks to Civil War history and regional museums.
Cruise Details
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Tennessee
from $4,915
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Music Cities Cruise

Memphis, TN to Nashville, TN - 9 Day Itinerary aboard American Symphony
  • Discover Memphis live music scene
  • Witness scenic cliffs
  • See Nashville’s iconic Hall of Fame
  • Walk at Clarksville’s streets
Starts / Ends
Memphis / Nashville
Activity Level
Variable
Travel from Memphis to Nashville on a 9-day river cruise aboard American Symphony. Enjoy live onboard music, explore cities like Paducah and Clarksville, and visit landmarks such as Fort Donelson and the Grand Ole Opry. Experience music, history, and river scenery through curated excursions and onboard activities.
Cruise Details
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A scenery in Tennessee
from $4,915
Savings
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Tennessee Rivers Cruise

Nashville to Chattanooga - 9 Day Itinerary aboard American Symphony
  • Explore Nashville’s music landmarks
  • Visit Paducah’s Quilt Museum
  • Walk historic Shiloh battlefield
  • Cruise through Appalachian scenery
Starts / Ends
Nashville / Chattanooga
Activities
Local Market Visits
Activity Level
Variable
Set sail on a 9-day Tennessee Rivers Cruise from Nashville to Chattanooga aboard American Symphony. Relax with expert talks, regional cuisine, and comfortable accommodation while exploring the history, culture, and natural beauty of America’s heartland.
Cruise Details
0
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