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Top Mekong River Trips & Tours in October 2025

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Discover Mekong River in October 2025 on one of these 37 tours hand-selected by the travel experts at Adventure Life. Explore the best of during October 2025 as you enjoy Village Visits, Local Market Visits, Archaeological Site Visits, Biking, and Wildlife Viewing. Prices for trips in October 2025 range from $990 to $23,290 for a vacation of 5 to 16 days. Choose any of the below 37 itineraries in October 2025 and customize it when you contact one of Adventure Life's expert Mekong River trip planners.
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    • Mekong River
Phnom Penh Royal Palace complex
from $2,124
EXPLORE

Mekong River - Upstream

Saigon to Phnom Penh - 4 Day Itinerary aboard The Jahan
  • Observed locals along the river
  • See the floating market in Cai Be
  • Visit Phnom Penh cultural sites
  • Visit Tan Chau floating fish farm
Starts / Ends
Ho Chi Minh City / Phnom Penh
Activity Level
Variable
On this 4-day journey from Saigon to Phnom Penh, cruise the lower Mekong River in majestic style aboard the Jahan. Discover the culture and history of the various towns along the mighty Mekong while exploring the river.
Cruise Details
0
Sunset over the Mekong River
from $3,358
EXPLORE

Classic Mekong

Upstream - 8 Day Itinerary aboard RV Bassac Pandaw
  • Explore the floating fish farms
  • Discover Ben Tre orchards
  • See Phnom Penh's National Museum
  • Tour local pottery village
Starts / Ends
Ho Chi Minh City / Siem Reap
Activities
Fishing
Activity Level
Variable
Explore both Vietnam's and Cambodia's striking cultural contrast in this 8-day Upstream Classic Mekong Cruise from Saigon to Siem Reap aboard RV Bassac Pandaw. Navigate the Mekong and Tonle Sap Rivers, visit historic temples, rural villages, floating fish farms, and bustling markets.
Cruise Details
0
Everyday life in Vietnam
from $3,439
EXPLORE

Charms of the Mekong - Cruise Only

Ho Chi Minh - Siem Reap - 8 Day Itinerary aboard MS Amadara
  • Explore Cai Be’s vibrant workshops
  • Discover Sa Dec history
  • Visit Phnom Penh landmarks
  • Experience Oknhatey, silk weaving
Starts / Ends
Ho Chi Minh City / Siem Reap
Activity Level
Variable
Embark on an 8-day river cruise aboard the MS Amadara, starting in Ho Chi Minh City, a vibrant blend of history and modernity. Cruise the Mekong River, exploring villages, pagodas, and markets and experiencing local traditions, including a monk’s blessing and artisan crafts.
Cruise Details
0
Boat floating along the Mekong River
EXPLORE

Experience the Mekong by Cruise

1 Day Itinerary
  • Visit a candy mill
  • Visit a coconut workshop
  • Enjoy biking or ride on a rickshaw
Starts / Ends
Mekong River / Mekong River
Activity Level
Relaxed
This one-day Vietnam tour extension includes a cruise along the Mekong River and visits to other scenic locations. Visit Ben Tre, My Long, a coconut workshop, a bee garden, a candy mill, and a farmer's house, and ride a rickshaw past coconut trees and vegetable farms.
Tour Details
0
Royal Palace and Silver Pagoda
from $1,956
EXPLORE

Mekong River - Downstream

Phnom Penh to Saigon - 4 Day Itinerary aboard Jayavarman
  • Observed locals along the river
  • Aboard a luxury riverboat in Mekong
  • Visit Phnom Penh cultural sites
  • Visit Tan Chau floating fish farm
Starts / Ends
Phnom Penh / Ho Chi Minh City
Activity Level
Variable
Cruise downstream on the Mekong River in majestic style aboard the Jayavarman on this 4-day journey from Phnom Penh to Saigon. Learn about the culture and heritage with visits to rural villages, historic pagodas, and colorful markets
Cruise Details
0
Traditional mat-making
from $2,124
EXPLORE

Mekong River - Downstream

Phnom Penh to Saigon - 4 Day Itinerary aboard The Jahan
  • Experience Binh Thanh Island
  • Explore My An Hung Village
  • Discover Tan Chau
  • Experience Cao Dai
Starts / Ends
Phnom Penh / My Tho
Activities
Biking
Activity Level
Variable
On this 4-day journey from Phnom Penh to Saigon, cruise downstream on the lower Mekong River in majestic style aboard the Jahan. See the stunning scenery and discover the culture and history of the various towns along the mighty Mekong.
Cruise Details
0
Phnom Penh Royal Palace complex
from $1,956
EXPLORE

Mekong River - Upstream

Saigon to Phnom Penh - 4 Day Itinerary aboard Jayavarman
  • Observed locals along the river
  • See the floating market in Cai Be
  • Visit Phnom Penh cultural sites
  • Visit Tan Chau floating fish farm
Starts / Ends
Ho Chi Minh City / Phnom Penh
Activity Level
Variable
On this 4-day journey from Saigon to Phnom Penh, cruise the lower Mekong River in majestic style aboard the Jayavarman. Discover the culture and history of the various towns along the mighty Mekong while exploring the river.
Cruise Details
0
The Vinh Trang Temple in My Tho, Vietnam
from $3,529
EXPLORE

From the Angkor Temples to the Mekong Delta

Siem Reap - Ho Chi Minh - 11 Day Itinerary aboard RV Indochine
  • Visit the Banteay Srei temple
  • Explore the terrace of Elephants
  • Discover Kampong Chhnang
  • Tour Phnom Penh's National Museum
Starts / Ends
Siem Reap / Ho Chi Minh City
Activity Level
Variable
Experience an 11-day cruise on the RV Indochine from Siem Reap to Ho Chi Minh City, navigating over 2,700 miles of the Mekong River. Explore cultural landmarks like Angkor and Phnom Penh, all while enjoying colonial-inspired comfort aboard your vessel.
Cruise Details
0
Woman on a boat in Vietnam
from $3,055
EXPLORE

From the Mekong Delta to Siem Reap

Ho Chi Minh City - Siem Reap - 9 Day Itinerary aboard RV Indochine II
  • Join a tour of Ho Ci Minh City
  • Observe Chau Doc´s vibrant market
  • Experience a trip in a “tuk tuk”
  • See Kampong Chhnang´s fish farms
Activity Level
Variable
Discover the culture and history of Vietnam & Cambodia on this 9-day cruise from Ho Chi Minh City to Siem Reap aboard the RV Indochine II, departing from Vietnam's Ho Chi Minh City towards Cambodia's Siem Reap, with stops in My Tho & Phnom Penh along the way.
Cruise Details
0
Vietnam's bird sanctuary
from $10,290
NO SS
EXPLORE

Mekong Expedition - Ho Chi Minh to Siem Reap

High water - 8 Day Itinerary aboard Aqua Mekong
  • Experience vibrant markets
  • Enjoy touring Cambodia's capital
  • Visit Long Son Pagoda
  • Explore Prek Toal Core Bird Reserve
Starts / Ends
Ho Chi Minh City / Siem Reap
Activity Level
Variable
Board the Aqua Mekong for an unforgettable 8-day cruise up the Mekong River from Saigon, Vietnam, to Siem Reap, Cambodia, with stops in Phnom Penh and Tonle Sap Lake, among other highlights of the Indochina peninsula. Biking, hiking, cultural immersion, market visits, and cooking classes highlight the cruise.
Cruise Details
0
Sanctuary Spa
from $990
EXPLORE

Farm House Resort and Spa Extension

4 Day Itinerary
  • Discover Kampong Chhnang
  • Relax at the Farmhouse Resort & Spa
  • Support local Cambodians
Starts / Ends
Phnom Penh / Kampong Chhnang
Activities
Village Visits, Spa Relaxation
Activity Level
Relaxed
This 4-day tour starts in Phnom Penh or Battambang. Drive about 1 hour and 30 minutes from Phnom Penh or 4 hours from Battambang. Upon arrival, settle into the Smiling Gecko Farmhouse. Relax and enjoy the natural surroundings and delicious meals provided throughout your stay.
Tour Details
0
Kampong Chhnang
from $3,439
EXPLORE

Riches of the Mekong - Cruise Only

8 Day Itinerary aboard MS Amadara
  • Explore Angkor Ban village
  • Visit Oknhatey, Silk Island
  • Tour Phnom Penh highlights
  • Discover Oudong, royal capital
Starts / Ends
Siem Reap / Ho Chi Minh City
Activities
Wildlife Viewing, Land & Sea Exploration
Activity Level
Variable
Embark on an 8-day river cruise from Siem Reap to Ho Chi Minh aboard the MS Amadara, exploring rural villages, bustling markets, and historic sites. Experience Cambodia and Vietnam’s rich culture through artisan crafts, temple visits, and unique rides by oxcart, tuk-tuk, and trishaw.
Cruise Details
0
The floating village of Tonle Sap, Cambodia
from $6,200
NO SS
EXPLORE

Mekong Explorer - Ho Chi Minh to Siem Reap (Extension)

5 Day Itinerary aboard Aqua Mekong
  • Enjoy a visit to a local's home
  • Walk through verdant plantations
  • Meet & interact with Buddhist Monks
  • Bike through Long Khanh
Starts / Ends
Ho Chi Minh City / Phnom Penh
Activity Level
Variable
Board the Aqua Mekong in My Tho for a 5-day Mekong River cruise of Cambodia & Vietnam, including stops in Ho Chi Minh City, Phnom Penh, and Long Son Pagoda atop Sam Mountain. Travel back in time as you cruise upriver through the thriving Mekong Delta past floating villages, colonial vestiges, and gilded pagodas.
Cruise Details
0
Floating Market in Cai Be
from $4,299
EXPLORE

Mekong River - Downstream - High water

Siem Reap to Saigon - 8 Day Itinerary aboard The Jahan
  • Aboard a luxury riverboat in Mekong
  • See the floating market in Cai Be
  • Observed locals along the river
  • Visit Tan Chau floating fish farm
  • Visit Phnom Penh cultural sites
Starts / Ends
Siem Reap / Ho Chi Minh City
Activity Level
Variable
Join this 8-day Mekong River cruise during the high water season from Siem Reap to Saigon. Get an inside look at the southern cultures of Vietnam and Cambodia as you travel across the mighty Mekong delta. Stop in charming port towns and immerse yourself in the city's culture and history.
Cruise Details
0
Flower farms in Sa Dec, Vietnam
from $3,788
EXPLORE

Mekong River - Upstream - High water

Saigon to Siem Reap - 8 Day Itinerary aboard Jayavarman
  • Explore rural villages
  • Discover skilled craftsmanship
  • Experience scenic views at Delta
  • Explore floating markets
  • Discover cultures of Mekong Delta
Starts / Ends
Ho Chi Minh City / Siem Reap
Activities
Local Market Visits, Archaeological Site Visits
Activity Level
Variable
Embark on this 8-day high river expedition on the Jayavarman and experience the Mekong River as it flows from Saigon to Siem Reap. Explore the lower Mekong and discover the diverse cultures and historical significance of the towns along its course.
Cruise Details
0
Sunset over the Mekong River
from $3,788
EXPLORE

Mekong River - Downstream - High water

Siem Reap to Saigon - 8 Day Itinerary aboard Jayavarman
  • Aboard a luxury riverboat in Mekong
  • See the floating market in Cai Be
  • Observed locals along the river
  • Visit Tan Chau floating fish farm
  • Visit Phnom Penh cultural sites
Starts / Ends
Siem Reap / Ho Chi Minh City
Activities
Cooking Classes
Activity Level
Variable
Explore the Mekong on this 8-day high-water Mekong River cruise from Siem Reap to Saigon. Get an inside look at the southern cultures of Vietnam and Cambodia as you travel across the mighty Mekong Delta. Stop in charming port towns and immerse yourself in the city's culture and history.
Cruise Details
0
Local moving cattle through the fields
from $5,098
EXPLORE

From the Temples of Angkor to the Mekong Delta & Hanoi and Halong Bay

14 Day Itinerary aboard RV Indochine
  • Discover 3 historical cities
  • Cross through the Cho Gao canal
  • Visit 4 major temples in Angkor
  • Meet locals and learn their culture
Starts / Ends
Siem Reap / Hanoi
Activities
Urban Exploration
Activity Level
Variable
This 14-day Mekong River cruise through Cambodia and Vietnam aboard the RV Indochine travels from Siem Reap in Cambodia to Hanoi, Vietnam observing imposing monuments, examples of finest architecture, and extraordinary landscapes, like those of famous Angkor Wat. Also visit Chau Doc, Ho Chi Minh City, Kampong Tralach, Koh Chen, My Tho, Sa Dec, & Tonle Sap Lake.
Cruise Details
0
Beautiful architecture in Tonle Sap
from $4,650
NO SS
EXPLORE

Mekong Discovery - Phnom Penh to Siem Reap

High water - 4 Day Itinerary aboard Aqua Mekong
  • Experience an indigenous tradition
  • Discover Koh Chen´s pottery
  • Explore the Moat Khla village
  • Kayak near the Tonle Sap Lake
Activities
Kayaking
Activity Level
Variable
Experience the colorful culture of Vietnam and Cambodia as you embark on this 4-day Mekong River Discovery Cruise from Phnom Penh to Siem Reap, and experience a richly-rewarding adventure by heading upriver in Cambodia and exploring the Tonle Sap Lake.
Cruise Details
0
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