Top Mekong River Trips & Tours in September 2025

Embark on an 8-day river cruise from Siem Reap to Ho Chi Minh aboard the MS Amadara, exploring rural villages, bustling markets, and historic sites. Experience Cambodia and Vietnam’s rich culture through artisan crafts, temple visits, and unique rides by oxcart, tuk-tuk, and trishaw.

This 14-day Mekong River cruise through Cambodia and Vietnam aboard the RV Indochine travels from Siem Reap in Cambodia to Hanoi, Vietnam observing imposing monuments, examples of finest architecture, and extraordinary landscapes, like those of famous Angkor Wat. Also visit Chau Doc, Ho Chi Minh City, Kampong Tralach, Koh Chen, My Tho, Sa Dec, & Tonle Sap Lake.

Experience an 11-day cruise on the RV Indochine from Siem Reap to Ho Chi Minh City, navigating over 2,700 miles of the Mekong River. Explore cultural landmarks like Angkor and Phnom Penh, all while enjoying colonial-inspired comfort aboard your vessel.

Experience the colorful culture of Vietnam and Cambodia as you embark on this 4-day Mekong River Discovery Cruise and experience a richly-rewarding adventure by heading upriver in Cambodia and exploring the Tonle Sap Lake.

Embark on a 16-day cruise aboard the MS Amadara, exploring Hanoi, Ha Long Bay, Siem Reap, and Ho Chi Minh City. Discover ancient temples, cruise the Mekong River, visit charming villages, and experience the vibrant blend of history and modern life in Vietnam and Cambodia.

Board the Aqua Mekong in My Tho for a 5-day Mekong River cruise of Cambodia & Vietnam, including stops in Ho Chi Minh City, Phnom Penh, and Long Son Pagoda atop Sam Mountain. Travel back in time as you cruise upriver through the thriving Mekong Delta past floating villages, colonial vestiges, and gilded pagodas.

Embark on a 5-day High Water river cruise aboard the Jayavarman from Phnom Penh to Siem Reap, and explore the captivating Cambodian culture while cruising the mighty Mekong Delta. Stop over at port towns and delve into the local culture and rich history of the cities.

Interact with the locals and visit colorful marketplaces and cultural attractions along the shorelines while on a tour of this beautiful region. Take a five-day cruise down the Mekong River aboard the Aqua Mekong.

Embark the luxurious Aqua Mekong in Phnom Pehn, Cambodia on this 4-day discovery cruise along the Mekong River all the way to Ho Chi Minh City, Vietnam. You'll peruse vibrant markets and visit typical Mekong Delta villages while getting to know local cultures and ways of life, with a visit to Vinh Trang Pagoda and opportunities to bike along the way.

Meander along the Mekong River as you cruise from Ho Chi Minh City to Siem Reap on this 10-day Vietnam & Cambodia cruise aboard Scenic Spirit. You'll enjoy an extensive lineup of included tours, large variety of land activities, visits to rural villages, historic pagodas, floating markets and a Buddhist monastery.

Board the Aqua Mekong for an excellent 4-day round-trip cruise from Phnom Penh along the Tonle Sap River. Along the way, you'll learn about a uniquely Buddhist practice at the Vipassana Dhura Mandala, enjoy a unique ox-cart ride, and see the Khmer Art Collection at the National Museum of Cambodia.

This one-day Vietnam tour extension includes a cruise along the Mekong River and visits to other scenic locations. Visit Ben Tre, My Long, a coconut workshop, a bee garden, a candy mill, and a farmer's house, and ride a rickshaw past coconut trees and vegetable farms.