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Coast of Ortigia island at city of Syracuse

Syracuse Sicily Cruises

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Experience the enchanting charm and rich history of Syracuse, Sicily, with Adventure Life's 17 diverse cruises for 2025. Join us on a cruise journey through this ancient city, where you can discover archaeological sites, indulge in delectable food & wine, and explore the vibrant culture of this Mediterranean gem. From wandering through charming villages to soaking up the sun on beautiful beaches, each moment offers a unique opportunity to immerse yourself in the wonders of this region. Engage in archaeological site visits, wildlife viewing, and urban exploration, all while surrounded by the natural beauty that has inspired artists for centuries. With prices starting at $2,460 to $35,480, begin your adventure to Syracuse, Sicily today and contact one of Adventure Life's tour specialists for help planning your next seamless trip.
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    • Syracuse
Explore Sibenik on the Dalmatian Coast
from $3,870
EXPLORE

Italy, Montenegro & Croatia

Venice - Civitavecchia - 12 Day Itinerary aboard Royal Clipper
  • Admire Venice’s domes
  • Wander Rovinj’s medieval streets
  • Discover Sibenik’s coastal lanes
  • Explore Kotor’s medieval town
Starts / Ends
Venice / Civitavecchia
Activities
Snorkeling
Activity Level
Variable
Set sail on a 12-day Royal Clipper cruise through the Mediterranean, visiting stunning destinations like Venice, Dubrovnik, and Syracuse. Experience rich history and culture while enjoying scenic views and a relaxing day at sea before concluding in Civitavecchia, near Rome.
Cruise Details
0
Coast of Ortigia island at city of Syracuse
from $2,590
EXPLORE

Sicily & Greece

Piraeus - Valletta - 9 Day Itinerary aboard Star Clipper
  • Explore Piraeus port city
  • Wander Nafplio charming town
  • Discover Monemvasia fortress
  • Visit Syracuse ruins
Starts / Ends
Piraeus / Valletta
Activities
Small Ship Sailing
Activity Level
Variable
Set sail on a 9-day cruise with Star Clipper, exploring Greece, Sicily, and Malta. Discover ancient sites, stunning landscapes, and cultural gems from Athens to Valletta while enjoying the charm of your ship.
Cruise Details
0
Cruise into charming Sicily
from $2,460
EXPLORE

Amalfi & Sicily

Civitavecchia Round-trip - 8 Day Itinerary aboard Royal Clipper
  • Gaze upon the Sistine Chapel
  • Snorkel at Palmarola
  • Visit historical Pompeii
  • Wander through the grand Duomo
Starts / Ends
Civitavecchia / Civitavecchia
Activity Level
Variable
Board the Royal Clipper on this 8-day cruise to Amalfi & Sicily of the Mediterranean. Admire the perfect architecture and magical landscapes that this region is famous for, visiting Sorrento, Taormina, Amalfi, Ponza, Palmarola, and more! Explore the Sistine Chapel, and the ancient ruins of Pompeii, and even wander through the Pontine Islands.
Cruise Details
0
Explore historic Bonifacio atop the cliffs of Corsica
from $7,790
EXPLORE

Mediterranean Island Voyage: Sicily, Sardinia, Corsica, and Elba – with Smithsonian Journeys

Valletta - Nice - 8 Day Itinerary aboard Le Bougainville
  • Discover Mediterranean islands
  • Experience ancient ruins
  • Admire Byzantine-Arab mosaics
  • Explore medieval towns
  • Discover local cuisine
Starts / Ends
Valletta / Nice
Activities
Land & Sea Exploration
Activity Level
Variable
Explore the heart of the Mediterranean on this 8-day Mediterranean Island Cruise with Smithsonian Journeys from Valletta to Nice aboard Le Bougainville. Discover Sicily, Sardinia, Corsica, and Elba's historical civilizations that left mark on these islands' language, cuisine, art, and architecture.
Cruise Details
0
Blue hour over the city in the shadow of Mount Etna
from $3,699
10% OFF
EXPLORE

Mediterranean Serenade

Roundtrip Malta - 8 Day Itinerary aboard Variety Voyager
  • Explore Gozo’s ancient temples
  • Discover Syracuse’s history
  • Taste Lipari’s finest wines
  • Swim in Malta’s waters
Starts / Ends
Valletta / Valletta
Activities
Wine Tasting
Activity Level
Variable
Embark on an 8-day cruise to and from Malta aboard the Variety Voyager. Discover the UNESCO World Heritage Ggantija temples on Gozo Island and Lipari in Sicily. Ascend Mount Etna and explore iconic "The Godfather" filming locations.
Cruise Details
0
Tour the charming city of Valletta, Malta.
from $9,450
EXPLORE

A Circumnavigation of Sicily with Smithsonian Journeys

Valletta - Valletta - 9 Day Itinerary aboard Le Bougainville
  • Take a loop around Sicily
  • Discover Sicily's beautiful cities
  • Visit Syracuse
  • Explore Palermo
Starts / Ends
Valletta / Valletta
Activity Level
Variable
During this 9-day cruise around Sicily aboard the new luxury expedition ship Le Bougainville, you'll be able to explore mythical places at the crossroads of Eastern and Western civilizations. Discover Sicily's most beautiful historic cities and ancient sites.
Cruise Details
0
Coast of Ortigia island at city of Syracuse
from $6,690
EXPLORE

Ancient Jewels of the Mediterranean

Valletta - Athens - 8 Day Itinerary aboard Le Dumont-d'Urville
  • Meet a famous puppeteer in Syracuse
  • Immerse in Southern Italy
  • Wander through the ancient streets
Starts / Ends
Valletta / Athens
Activity Level
Variable
Set sail on an 8-day Ancient Jewels of the Mediterranean cruise aboard Le Dumont-d'Urville! Explore Malta's coast and Greece's treasures. Discover Syracuse's puppetry, Paros' villages, and Taormina's ancient theatre. Experience Gallipoli, Galaxidi, Hydra, and Paros.
Cruise Details
0
Coast of Ortigia island at city of Syracuse
from $5,510
EXPLORE

Ancient Jewels of the Mediterranean

Athens - Valletta - 8 Day Itinerary aboard L'Austral
  • Meet a famous puppeteer in Syracuse
  • Discover Southern Italy's history
  • Cross the Corinth Canal to Galaxidi
  • Explore Paros and its white marbles
Starts / Ends
Athens / Valletta
Activity Level
Variable
Embark on an 8-day adventure on L’Austral from Athens to the Maltese coast. Enjoy excursions at each port, including visits to Hydra's monuments, Paros, and Galaxidi. In southern Italy, discover Gallipoli's Greek heritage, Taormina's ancient theatre, and Ortygia's historic streets. The cruise concludes in Valletta, the capital of Malta.
Cruise Details
0
Visit the Baroque Cathedral of Syracuse
from $8,220
EXPLORE

Cruising Southern Italy and Sicily – with Smithsonian Journeys

Valletta - Livorno - 9 Day Itinerary aboard Le Dumont-d'Urville
  • Explore Valletta's heritage
  • Discover Syracuse's history
  • Admire Taormina's scenic views
  • Experience Naples culture
Starts / Ends
Valletta / Livorno
Activity Level
Variable
Sail on this 9-day Southern Italy and Sicily cruise with Smithsonian Journeys aboard Le Dumont-d'Urville. Start in Valletta, Malta, exploring historic landmarks. Visit Syracuse's Greek and cultural sites and Taormina's scenic views and theater. Explore Reggio di Calabria's coast and museum. Visit Civitavecchia, and conclude in Livorno, Tuscany.
Cruise Details
0
Beautiful Taormina, Italy, with Mt. Etna in the background
from $9,920
EXPLORE

Epicurean Delights of Sicily and the Adriatic Coast of Italy

Valletta to Venice - 9 Day Itinerary aboard Le Bougainville
  • Visit Valletta's UNESCO sites
  • Explore ancient Syracuse ruins
  • Visit Taormina's Greek Theater
  • Savor Apulian wine and food
  • Discover Venice’s hidden gardens
  • Enjoy Ravenna's stunning mosaics
  • Mount Etna wine tasting
Starts / Ends
Valletta / Venice
Activity Level
Variable
Embark on a 9-day Le Bougainville trip through Sicily and Italy’s Adriatic coast, visiting UNESCO sites like Valletta, Syracuse, and Venice. Explore ancient ruins, Baroque cities, and medieval towns, while enjoying local wines, cheeses, and dishes prepared by chef Denny Imbroisi.
Cruise Details
0
from $14,158
EXPLORE

The Ancient Shores of Sicily and Malta

Roundtrip Malta - 10 Day Itinerary aboard Sea Cloud II
  • Explore stunning UNESCO-listed site
  • Step into the history of Sicily
  • Discover the charm of ancient Erice
  • Savor the authentic Sicily flavors
  • Explore historic Taormina and Sirac
Starts / Ends
Valletta / Valletta
Activity Level
Variable
Embark on a 10-day Ancient Shores of Sicily and Malta cruise, aboard Sea Cloud II. Explore ancient cities, UNESCO-listed temples, and landscapes shaped by the Romans, Greeks, and Carthaginians. Visit Agrigento’s Valley of the Temples, the Ggantija Temples, and Valletta, stroll medieval Erice, and tour The Godfather’s Castello degli Schiavi.
Cruise Details
0
from $9,540
EXPLORE

Culture and Islands of the Mediterranean

Barcelona - Valletta - 12 Day Itinerary aboard L'Austral
  • Visit Menorca
  • Explore Sardinia
  • Discover Sicily
  • Experience Catania
  • Discover Syracuse
  • Discover Malta
Starts / Ends
Barcelona / Valletta
Activities
Urban Exploration
Activity Level
Variable
Embark on a 12-day cruise from Barcelona to Malta aboard L’Austral. Enjoy culinary and cultural experiences with an included excursion per port. Highlights include Menorca, Alghero, Cagliari, Trapani, Palermo, Lipari, Catania, Syracuse, Gozo, and ending in Valletta.
Cruise Details
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Visit Rome's famed Colosseum
from $12,795
EXPLORE

The Amalfi, Sicily and Malta: The Godfather

Rome to Malta - 12 Day Itinerary aboard Douglas Mawson
  • Guided Tour of Rome
  • Vatican City Exploration
  • Sicilian Wine Tasting
  • Explore Pompeii Ruins
  • Discover Amalfi Coast
  • Stroll Baroque Town of Ragusa
  • Valletta’s Historical Sights
Starts / Ends
Rome / Valletta
Activity Level
Variable
Join a 12-day Douglas Mawson expedition through the Amalfi Coast, Sicily, and Malta to explore ancient cities, scenic resorts, and a history shaped by family feuds and political intrigue. Enjoy personalized experiences with guided tours, wine tastings, and visits to iconic sites, ending in Malta’s capital, Valletta, with its fortifications and historic landmarks.
Cruise Details
0
Visit beautiful Hydra
from $10,390
EXPLORE

Ancient Wonders of the Mediterranean

Athens - Valletta - 13 Day Itinerary aboard Le Dumont-d'Urville
  • Explore the rocky plateau of Athens
  • Explore Patmos
  • Admire volcanic beauty and ruins
  • Explore the Delphi Sanctuary
Starts / Ends
Athens / Valletta
Activity Level
Variable
Embark on a 13-day Mediterranean cruise aboard Le Dumont-d'Urville, exploring the enchanting destinations of Greece, Turkey, and Italy. Each destination offers unique experiences, from ancient ruins and historic monasteries to stunning beaches and charming villages.
Cruise Details
0
Explore ruins in Taormina within view of volcanic Mount Etna
from $6,170
EXPLORE

Grand Voyage: Rome to Lisbon

Civitavecchia - Lisbon - 21 Day Itinerary aboard Royal Clipper
  • Explore Sorrento’s coastal cliffs
  • Wander Amalfi’s medieval streets
  • Uncover Syracuse’s history
  • Admire Lipari’s vibrant marina
Starts / Ends
Civitavecchia / Lisbon
Activities
Wildlife Viewing, Archaeological Site Visits, Village Visits, Local Market Visits
Activity Level
Relaxed
Embark on a 21-day cruise aboard the Royal Clipper from Rome to Lisbon, exploring stunning cities like the Amalfi Coast, Sicily, and the Balearic Islands. Enjoy optional excursions to historic sites while relaxing onboard with sailing and adventure activities amidst breathtaking landscapes.
Cruise Details
0
Relax in beautiful Sicily
from $8,370
EXPLORE

A Circumnavigation of Sicily with Smithsonian Journeys

Valletta Roundtrip - 9 Day Itinerary aboard Le Dumont-d'Urville
  • Visit Valleta a UNESCO-listed city
  • Visit Valley of Temples
  • Witness a fiery volcano
  • Discover Trapani's diverse heritage
Starts / Ends
Valletta / Valletta
Activity Level
Variable
Set sail on a 9-day Sicily cruise aboard Le Dumont-d'Urville. Visit UNESCO sites like Valletta and the Valley of Temples, admire Stromboli’s volcanic activity, explore vibrant cities such as Palermo and Syracuse, and discover ancient ruins, diverse cultures, and beautiful coastal views.
Cruise Details
0
Beautiful Taormina, Italy, with Mt. Etna in the background
from $5,750
EXPLORE

Ancient Jewels of the Mediterranean

Valletta - Athens - 8 Day Itinerary aboard Le Bougainville
  • Meet a famous puppeteer in Syracuse
  • Immerse in Southern Italy
  • Wander through the ancient streets
  • Visit the Taormina in Sicily
Starts / Ends
Valletta / Athens
Activity Level
Variable
Set sail on an 8-day Ancient Jewels of the Mediterranean cruise aboard Le Bougainville. Explore Malta's coast and Greece's treasures. Discover Syracuse's puppetry, Paros' villages, and Taormina's ancient theatre. Experience Gallipoli, Galaxidi, Hydra, and Paros.
Cruise Details
0
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