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Maysville, Kentucky River Cruises

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Experience the charm of Maysville, Kentucky, on one of Adventure Life's River Cruises. With 1 unique tours available in 2025, ranging from 16 days in length, you can sail along the picturesque Ohio River, immersing yourself in the rich history and culture of this quaint river town. Discover the beauty of the rolling hills, explore local markets, and indulge in delicious food and wine offerings. From wildlife viewing to village visits, hiking to wine tasting, there is something for every type of traveler. Join us on a cruise to Maysville and let the serene waters guide you through an unforgettable journey. Contact one of our award-winning river cruise experts for help planning your next seamless trip.
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View the iconic arch when you visit St. Louis, gateway to the west
from $9,240
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Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody
  • Explore historic Marietta, Ohio
  • Explore Maysville’s Railroad
  • Visit Louisville’s Churchill Downs
  • Tour Paducah’s wall murals
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Pittsburgh / St. Louis
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Wildlife Viewing, Village Visits, Urban Exploration, Archaeological Site Visits
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Variable
Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.
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