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La Crosse Wisconsin River Cruises

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Experience the charming city of La Crosse in Wisconsin with Adventure Life's 2 exciting Cruises for 2025. Join us on a cruise journey through the beautiful Mississippi River, where you can immerse yourself in the region's rich cultural heritage and stunning natural landscapes. Explore the picturesque riverfront, indulge in delicious local cuisine, and discover the vibrant history of this hidden gem. With activities like wildlife viewing and village visits, this adventure offers a perfect blend of relaxation and exploration for all travelers. Don't miss the chance to sail through the heart of the Midwest and create unforgettable memories in La Crosse. Contact one of Adventure Life's La Crosse specialists for help planning your next seamless trip.
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    • La Crosse
Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $12,620
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Grand Heartland Cruise

Minnesota - Louisiana - 16 Day Itinerary aboard American Serenade
Starts / Ends
St. Paul / New Orleans
Activities
Village Visits, Archaeological Site Visits, Wine Tasting, Urban Exploration, Wildlife Viewing, Local Market Visits, Biking
Activity Level
Variable
Embark on a 16-day Mississippi River cruise from Minnesota to Louisiana aboard American Serenade, exploring St. Paul to New Orleans with stops in La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, and Natchez. Enjoy onboard activities, stunning scenery, and experiences like the Mark Twain Boyhood Home and more.
  • Visit mansions and art galleries
  • See the Gateway Arch and St. Louis
  • Visit Natchez’s antebellum homes
  • Experience Memphis' musical legacy
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View the iconic arch when you visit St. Louis, gateway to the west
from $12,999
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America’s Great River

St. Paul to New Orleans - 15 Day Itinerary aboard Viking Mississippi
Starts / Ends
St. Paul / New Orleans
Activity Level
Variable
Cruise America's great river on this 15-day itinerary aboard Viking Mississippi. Journey from St. Paul, Minnesota to New Orleans, Louisiana and explore highlights of the mighty Mississippi River. Along the way, visit historic ports such as St. Louis, Memphis, Baton Rouge, and more.
  • Explore St. Louis' arts scene
  • Enjoy American music styles
  • Learn Civil War history
  • Experience New Orleans' culture
  • Visit the Quad Cities
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