Top Mississippi River Tours & Cruises in 2028

Discover America’s heartland on an 8-day Viking Mississippi cruise from Alton to Red Wing, exploring St. Louis, Hannibal, Burlington, the Quad Cities, Dubuque, and La Crosse. From Mark Twain’s hometown to the Mississippi River Museum, each stop offers a direct look into the nation’s past.

Set sail for 9 days aboard American Serenade from St. Paul to St. Louis. Walk through historic Summit Avenue, admire La Crosse from Grandad’s Bluff, explore Dubuque’s River Museum, and discover Mark Twain’s legacy in Hannibal. Experience curated onboard programs, live music, and the beauty of the Upper Mississippi’s diverse wildlife.

Cruise America's great river on this 15-day itinerary aboard Viking Mississippi. Journey from St. Paul, Minnesota to New Orleans, Louisiana and explore highlights of the mighty Mississippi River. Along the way, visit historic ports such as St. Louis, Memphis, Baton Rouge, and more.

Sail the Mississippi River from St. Paul to New Orleans on a 16-day cruise aboard American Melody. Visit La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, Natchez, and Baton Rouge while exploring river history, Native heritage, Civil War sites, music, architecture, museums, agriculture, and regional culture.

The American Heritage hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.

Discover early 19th-century life and Civil War history on a 15-day cruise aboard the Viking Mississippi. Visit grand plantations, memorials, and key sites of the Civil Rights Movement while enjoying regional traditions along the iconic river.

Cruise the Mississippi River on a 16-day voyage aboard American Serenade. Visit La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Tunica, Vicksburg, Natchez, and Baton Rouge while exploring museums, riverfronts, historic landmarks, Civil War sites, and music destinations. Enjoy scenic cruising through the Upper and Lower Mississippi.

On this 8-day Mississippi Delta Explorer from New Orleans to Memphis aboard the Viking Mississippi, visit historic towns like Darrow, Natchez, and Vicksburg. Enjoy Cajun and Creole cuisine, Memphis barbecue, and explore the South’s rich history, culture, and music.

Explore the highlights of the Mississippi River on this 8-day cruise roundtrip from New Orleans aboard Viking Mississippi. Discover port cities such as St. Francisville, Darrow, Baton Rouge, Natchez, and Vicksburg to experience the diverse culture and rich history of the lower Mississippi region.

Explore the Upper Mississippi River on this 9-day cruise from St. Louis to Minneapolis aboard the American Melody. Begin in St. Louis, Missouri, and travel through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.

Embark on a 9-day cruise from New Orleans to Memphis aboard American Melody, exploring Southern culture and history with local guides. Enjoy enriching excursions, gourmet meals, daily cocktails, and captivating shows at historic sites like Vicksburg and Natchez.

Cruise aboard American Heritage on a 9-day cruise from New Orleans to Memphis along the Mississippi River. Visit Oak Alley, Baton Rouge, Natchez, Vicksburg, and Cleveland. Explore historic plantations, Civil War sites, blues landmarks, museums, and riverfront towns while experiencing the culture and history of the American South.