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Mississippi River, St. Paul Minnesota

Top Mississippi River Tours & Cruises in 2027

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Discover the best the world has to offer with Adventure Life’s expert-curated Mississippi River tours 2027. From New Orleans, Memphis, Natchez, Vicksburg, and Baton Rouge to hidden gems off the beaten path, our 23 top-rated itineraries take you deep into Mississippi River’s breathtaking landscapes. Guided by bilingual experts, these immersive experiences cater to adventurers seeking unique journeys in small groups or customizable private tours.

Choose from a variety of 8 to 23 days itineraries starting at $3,630 to $33,999. You’ll find options that suit your travel style. Whether you’re passionate about Archaeological Site Visits, Urban Exploration, Village Visits, Wine Tasting, and Local Market Visits or eager to explore Mississippi River’s rich culture and natural beauty, our Mississippi River tours 2027 deliver unforgettable moments. Each itinerary blends awe-inspiring exploration with a commitment to sustainability to ensure your adventure supports the preservation of our planet.

Adventure Life’s dedication to personalized travel promises your Mississippi River tour 2027 is seamless from start to finish. From arranging transportation to selecting accommodations tailored to your preferences, we’ll take care of every detail. Our expert recommendations and insider tips make your journey even more enriching.

Contact our specialists today to start planning your Mississippi River tour 2027. Whether you’re a solo traveler, a couple, or part of a group, Adventure Life will create a transformative experience you’ll treasure forever.
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    • Mississippi River
Tennessee
from $5,275
Savings
EXPLORE

Music Cities Cruise

Memphis, TN to Nashville, TN - 9 Day Itinerary aboard American Symphony
  • Discover Memphis live music scene
  • Witness scenic cliffs
  • See Nashville’s iconic Hall of Fame
  • Walk at Clarksville’s streets
Starts / Ends
Memphis / Nashville
Activity Level
Variable
Travel from Memphis to Nashville on a 9-day river cruise aboard American Symphony. Enjoy live onboard music, explore cities like Paducah and Clarksville, and visit landmarks such as Fort Donelson and the Grand Ole Opry. Experience music, history, and river scenery through curated excursions and onboard activities.
Cruise Details
0
Visit historic St. Louis
from $5,999
EXPLORE

Heartland of America

Missouri to Minnesota - 8 Day Itinerary aboard Viking Mississippi
  • Walk Mark Twain’s Hannibal
  • Explore John Deere innovations
  • Explore historic Burlington charm
  • Explore ancient mound builders
Starts / Ends
St. Louis / St. Paul
Activities
Hiking
Activity Level
Variable
Discover America’s heartland on an 8-day Viking Mississippi cruise from Alton to Red Wing, exploring St. Louis, Hannibal, Burlington, the Quad Cities, Dubuque, and La Crosse. From Mark Twain’s hometown to the Mississippi River Museum, each stop offers a direct look into the nation’s past.
Cruise Details
0
View the iconic arch when you visit St. Louis, gateway to the west
from $12,999
EXPLORE

America’s Great River

St. Paul to New Orleans - 15 Day Itinerary aboard Viking Mississippi
  • Explore St. Louis' arts scene
  • Enjoy American music styles
  • Learn Civil War history
  • Experience New Orleans' culture
  • Visit the Quad Cities
Starts / Ends
St. Paul / New Orleans
Activity Level
Variable
Cruise America's great river on this 15-day itinerary aboard Viking Mississippi. Journey from St. Paul, Minnesota to New Orleans, Louisiana and explore highlights of the mighty Mississippi River. Along the way, visit historic ports such as St. Louis, Memphis, Baton Rouge, and more.
Cruise Details
0
Bridge across the Mississippi at Cape Girardeau
from $5,275
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Symphony
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Starts / Ends
Memphis / New Orleans
Activity Level
Variable
Experience a 9-day cruise aboard American Symphony from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.
Cruise Details
0
Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $5,635
Savings
EXPLORE

Upper Mississippi River

St. Paul, MN - St. Louis, MO - 9 Day Itinerary aboard American Serenade
  • Tour historic Summit Avenue
  • Explore Dubuque River Museum
  • Experience John Deere Pavilion
  • Visit Mark Twain’s boyhood home
Starts / Ends
St. Paul / St. Louis
Activities
Wine Tasting, Biking, Wildlife Viewing
Activity Level
Variable
Set sail for 9 days aboard American Serenade from St. Paul to St. Louis. Walk through historic Summit Avenue, admire La Crosse from Grandad’s Bluff, explore Dubuque’s River Museum, and discover Mark Twain’s legacy in Hannibal. Experience curated onboard programs, live music, and the beauty of the Upper Mississippi’s diverse wildlife.
Cruise Details
0
Visit Louisiana's capital city of Baton Rouge
from $3,630
Savings
EXPLORE

Historic Mississippi River Cruise

New Orleans Roundtrip - 8 Day Itinerary aboard American Heritage
  • Experience Natchez’s beauty
  • Visit historic Civil War sites
  • Discover Oak Alley's historic charm
  • Visit charming ports and cities
Starts / Ends
New Orleans / New Orleans
Activity Level
Variable
The American Heritage hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.
Cruise Details
0
Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $12,620
Savings
EXPLORE

Grand Heartland Cruise

Minnesota - Louisiana - 16 Day Itinerary aboard American Serenade
  • Visit mansions and art galleries
  • See the Gateway Arch and St. Louis
  • Visit Natchez’s antebellum homes
  • Experience Memphis' musical legacy
Starts / Ends
St. Paul / New Orleans
Activity Level
Variable
Embark on a 16-day Mississippi River cruise from Minnesota to Louisiana aboard American Serenade, exploring St. Paul to New Orleans with stops in La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, and Natchez. Enjoy onboard activities, stunning scenery, and experiences like the Mark Twain Boyhood Home and more.
Cruise Details
0
Wander through the historic French Quarter
from $3,999
EXPLORE

New Orleans & Southern Charms

Roundtrip New Orleans - 8 Day Itinerary aboard Viking Mississippi
  • Enjoy Cajun and Creole cuisine
  • Indulge in New Orleans' music
  • Learn the history of Vicksburg
  • See the historic homes of Natchez
Starts / Ends
New Orleans / New Orleans
Activities
Festival Visits
Activity Level
Variable
Explore the highlights of the Mississippi River on this 8-day cruise roundtrip from New Orleans aboard Viking Mississippi. Discover port cities such as St. Francisville, Darrow, Baton Rouge, Natchez, and Vicksburg to experience the diverse culture and rich history of the lower Mississippi region.
Cruise Details
0
Natchez
from $4,299
EXPLORE

Mississippi Delta Explorer

New Orleans - Memphis - 8 Day Itinerary aboard Viking Mississippi
  • Explore Darrow
  • Visit Natchez historic sites
  • Learn the history of Vicksburg
  • Culinary adventure of Mississippi
  • Know the history of rock 'n' roll
  • American South's Cultural Heritage
Starts / Ends
New Orleans / Memphis
Activity Level
Variable
On this 8-day Mississippi Delta Explorer from New Orleans to Memphis aboard the Viking Mississippi, visit historic towns like Darrow, Natchez, and Vicksburg. Enjoy Cajun and Creole cuisine, Memphis barbecue, and explore the South’s rich history, culture, and music.
Cruise Details
0
Visit the Quad cities, including Davenport, Iowa
from $5,635
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Melody
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Experience wildlife and nature
  • Admire local artwork in Red Wing
Starts / Ends
St. Louis / Red Wing
Activity Level
Variable
Explore the Upper Mississippi River on this 9-day cruise from St. Louis to Minneapolis aboard the American Melody. Begin in St. Louis, Missouri, and travel through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
Cruise Details
0
View monuments from the Civil War in Mississippi
from $4,610
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Heritage
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Starts / Ends
Memphis / New Orleans
Activity Level
Variable
Experience a 9-day cruise aboard American Heritage from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.
Cruise Details
0
Visit Louisiana's capital city of Baton Rouge
from $4,295
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Splendor
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Starts / Ends
Memphis / New Orleans
Activity Level
Variable
Experience a 9-day cruise aboard American Heritage from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.
Cruise Details
0
Visit historic Minneapolis
from $15,890
Savings
EXPLORE

Complete Mississippi River

New Orleans - St. Paul - 23 Day Itinerary aboard American Melody
  • Explore Natchez's Grand Homes
  • Visit Oak Alley
  • Delve into Baton Rouge's history
  • Unravel Vicksburg's Civil War
Starts / Ends
New Orleans / St. Paul
Activity Level
Variable
Discover the Mighty Mississippi on a 23-day cruise covering 10 states aboard American Melody. Immerse in history, culture, and cuisine from New Orleans to Minneapolis, exploring charming ports along the way.
Cruise Details
0
Explore the rivers of America
from $5,275
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Melody
  • Admire the diversity of New Orleans
  • Visit Myrtles' haunted estate
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Starts / Ends
Memphis / New Orleans
Activities
Cooking Classes
Activity Level
Variable
Experience a 9-day cruise aboard American Melody from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.
Cruise Details
0
Vicksburg Battlefield overlooking the Mississippi River
from $4,610
Savings
EXPLORE

Lower Mississippi River Cruise

New Orleans - Memphis - 9 Day Itinerary aboard American Heritage
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Starts / Ends
New Orleans / Memphis
Activity Level
Variable
Experience a 9-day cruise aboard American Heritage from New Orleans to Memphis, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.
Cruise Details
0
Visit historic Memphis, Tennessee
from $7,275
Savings
EXPLORE

Mississippi Explorer

New Orleans - Memphis - 12 Day Itinerary aboard American Symphony
  • Explore Natchez's Grand Homes
  • Visit Oak Alley
  • Delve into Baton Rouge's history
  • Unravel Vicksburg's Civil War
Starts / Ends
New Orleans / Memphis
Activity Level
Variable
Set sail on a 12-day Mississippi river cruise aboard the American Symphony, from New Orleans to Memphis, visiting Southern landmarks like Oak Alley, Houmas House, and Vicksburg National Military Park. Explore Baton Rouge's history, Natchez's antebellum homes, and Cleveland's musical heritage.
Cruise Details
0
Explore beautiful Nashville
from $5,999
EXPLORE

Nashville, Memphis & the Cumberland

Memphis to Nashville - 8 Day Itinerary aboard Viking Mississippi
  • Discover Memphis blues roots
  • See Paducah murals
  • Walk historic Clarksville streets
  • Cruise Tennessee River scenery
Starts / Ends
Memphis / Nashville
Activity Level
Variable
Take an 8-day Viking Mississippi cruise through Memphis, Cape Girardeau, Paducah, Clarksville, and Nashville. Visit key cultural and historical sites, from music landmarks to Civil War history and regional museums.
Cruise Details
0
Enjoy the colorful architecture of New Orleans
from $5,275
Savings
EXPLORE

Lower Mississippi River Cruise

New Orleans - Memphis - 9 Day Itinerary aboard American Melody
  • Explore New Orleans lively culture
  • Discover Oak Alley with landscapes
  • Uncover St Francisville stories
  • Engage Cleveland music heritage
Starts / Ends
New Orleans / Memphis
Activities
Village Visits, Urban Exploration, Archaeological Site Visits, Local Market Visits
Activity Level
Variable
Embark on a 9-day cruise from New Orleans to Memphis aboard American Melody, exploring Southern culture and history with local guides. Enjoy enriching excursions, gourmet meals, daily cocktails, and captivating shows at historic sites like Vicksburg and Natchez.
Cruise Details
0
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