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Mississippi River, St. Paul Minnesota

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Select one of the below 18 best Mississippi River trips for 2024 and 2025. Your local English-speaking guide will lead your small group or personalized private tour on an extraordinary adventure exploring New Orleans, Natchez, Vicksburg, Baton Rouge, and Memphis. Our Mississippi River trips for 2024 feature cruises, river cruises, cultural, village visits, and urban exploration, and start from $3,475 for trips of 8 to 23 days. Contact Adventure Life's Mississippi River trip planning experts to start planning your next seamless trip.
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    • Mississippi River
View the iconic arch when you visit St. Louis, gateway to the west
$12,999
EXPLORE

America’s Great River

St. Paul to New Orleans - 15 Day Itinerary aboard Viking Mississippi
  • Explore St. Louis' arts scene
  • Enjoy American music styles
  • Learn Civil War history
  • Experience New Orleans' culture
  • Visit the Quad Cities
Starts / Ends:
St. Paul / New Orleans
Activities:
Archaeological Site Visits, River Cruises, Village Visits
Activity Level:
Relaxed
Discover the history, natural beauty, and distinctive regional cultures of America's great river, the mighty Mississippi, on this 15-day cruise aboard Viking Mississippi. Set sail from St. Paul, Minnesota, and venture south toward New Orleans, Louisiana. Along the way, visit small towns and …
Cruise Details
0
Visit historic Memphis, Tennessee
$5,499
EXPLORE

Heart of the Delta

New Orleans to Memphis - 12 Day Itinerary aboard Viking Mississippi
  • Enjoy the music of Memphis
  • Get a taste of Cajun cuisine
  • Discover Civil War history
  • See the historic homes of Natchez
Starts / Ends:
New Orleans / Memphis
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
Immerse yourself in the history and heritage of the Mississippi River on this 12-day voyage from New Orleans to Memphis. Soak up the rich French and Acadian cultures that infuse the Lower Mississippi, and be inspired by the stories of famed musicians and Civil Rights heroes. Savor delicious Cajun …
Cruise Details
0
Wander through the historic French Quarter
$3,999
EXPLORE

New Orleans & Southern Charms

8 Day Itinerary aboard Viking Mississippi
  • Enjoy Cajun and Creole cuisine
  • Indulge in New Orleans' music
  • Learn the history of Vicksburg
  • See the historic homes of Natchez
Starts / Ends:
New Orleans / New Orleans
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Relaxed
The Lower Mississippi overflows with charm, history and hospitality. Wander historic estates, and visit notable Civil War sites. Explore the bustling French-influenced port cities of New Orleans and Baton Rouge. Sway to the tempos of Dixieland jazz, gospel and blues. Savor gourmet Cajun and Creole …
Cruise Details
0
The upper Mississippi region
$6,999
EXPLORE

America’s Heartland

St. Louis to St. Paul - 12 Day Itinerary aboard Viking Mississippi
  • Discover history of the Mississippi
  • Explore Dubuque, Iowa
  • Experience Mississippi river towns
  • Admire local artisan work
Starts / Ends:
St. Louis / St. Paul
Activities:
Archaeological Site Visits, River Cruises, Village Visits
Activity Level:
Relaxed
On this enlightening journey on the Upper Mississippi, hear stories of pioneers and the Lewis and Clark Expedition; walk in the footsteps of Mark Twain; and learn about the Norwegian migration. Enjoy the view as your ship navigates through the river’s intricate lock system. Experience the …
Cruise Details
0
Visit historic Memphis, Tennessee
$5,190
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Symphony
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Starts / Ends:
Memphis / New Orleans
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Variable
Embark on a captivating 9-day cruise aboard the American Symphonyfrom Memphis to New Orleans, navigating the mighty Mississippi River. Explore Memphis' musical legacy and vibrant culture before cruising through days of enchanting river views. Vicksburg unfolds its Civil War history, Natchez …
Cruise Details
0
Memphis, Tennesse, USA downtown cityscape at dusk over Beale Street
$5,190
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Melody
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Starts / Ends:
Memphis / New Orleans
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Variable
Embark on a captivating 9-day cruise aboard the American Melodyfrom Memphis to New Orleans, navigating the mighty Mississippi River. Explore Memphis' musical legacy and vibrant culture before cruising through days of enchanting river views. Vicksburg unfolds its Civil War history, Natchez …
Cruise Details
0
Visit Louisiana's capital city of Baton Rouge
$4,530
Savings
EXPLORE

Lower Mississippi River Cruise

Memphis - New Orleans - 9 Day Itinerary aboard American Heritage
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Starts / Ends:
Memphis / New Orleans
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Variable
Embark on a captivating 9-day cruise aboard the American Heritagefrom Memphis to New Orleans, navigating the mighty Mississippi River. Explore Memphis' musical legacy and vibrant culture before cruising through days of enchanting river views. Vicksburg unfolds its Civil War history, Natchez …
Cruise Details
0
Visit Louisiana's capital city of Baton Rouge
$3,475
Savings
EXPLORE

Historic Mississippi River Cruise

New Orleans Roundtrip - 8 Day Itinerary aboard American Heritage
  • Explore the antebellum of Natchez
  • Visit historic Civil War sites
  • Discover Oak Alley's historic charm
  • Visit charming ports and cities
Starts / Ends:
New Orleans / New Orleans
Activities:
River Cruises, Urban Exploration
Activity Level:
Variable
Board American Heritage for this 8-day cruise along the Mississippi River. Explore unique sites and attractions, admiring the beauty of the world on a roundtrip river cruise from New Orleans. Uncover the history of Oak Alley Plantation, Baton Rouge's dynamic blend of history and modernity, and …
Cruise Details
0
Mississippi River, St. Paul Minnesota
$5,545
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Melody
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Witness wildlife and nature
  • Admire local artwork in Red Wing
Starts / Ends:
St. Louis / Red Wing
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Variable
Embark on a cruise along the Upper Mississippi River, exploring St. Louis, Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's home, witness diverse landscapes, and enjoy expert-guided tours. Adapt to the river's character as you relax on lounges, decks, or …
Cruise Details
0
Visit Louisiana's capital city of Baton Rouge
$4,530
Savings
EXPLORE

Lower Mississippi River Cruise

New Orleans - Memphis - 9 Day Itinerary aboard American Heritage
  • Admire the diversity of New Orleans
  • Discover the cultures of the delta
  • Learn the history of Vicksburg
  • Enjoy the music of Memphis
Starts / Ends:
New Orleans / Memphis
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Variable
Embark on a 9-day cruise aboard the American Heritage from New Orleans to Memphis. Explore New Orleans with its culinary delights, music, and culture. Sail the Mississippi River, visit historic sites, and enjoy onboard entertainment. Explore plantations, museums, swamps, and antebellum homes. …
Cruise Details
0
Visit historic Memphis, Tennessee
$11,755
Savings
EXPLORE

Grand Heartland Cruise

Minnesota - Louisiana - 16 Day Itinerary aboard American Serenade
  • Visit mansions and art galleries
  • See the Gateway Arch and St. Louis
  • Visit Natchez’s antebellum homes
  • Experience Memphis' musical legacy
Starts / Ends:
St. Paul / New Orleans
Activities:
Village Visits
Activity Level:
Variable
Embark on a 16-day cruise aboard American Serenade and begin by exploring St. Paul's art galleries and historic Summit Avenue. In La Crosse, enjoy Riverside Park and panoramic views from Grand Dad’s Bluff. Discover Dubuque, with its Victorian mansions and the Mississippi River Museum …
Cruise Details
0
Explore historic New Orleans
$4,190
Savings
EXPLORE

Historic Mississippi River Cruise

New Orleans Roundtrip - 8 Day Itinerary aboard American Melody
  • Explore the antebellum of Natchez
  • Visit historic Civil War sites
  • Discover Oak Alley's historic charm
  • Visit charming ports and cities
Starts / Ends:
New Orleans / New Orleans
Activities:
River Cruises, Urban Exploration
Activity Level:
Variable
Board American Melody for this 8-day cruise along the Mississippi River. Explore unique sites and attractions, admiring the beauty of the world on a roundtrip river cruise from New Orleans. Uncover the history of Oak Alley Plantation, Baton Rouge's dynamic blend of history and modernity, and …
Cruise Details
0
Visit historic Minneapolis
$15,640
Savings
EXPLORE

Complete Mississippi River

New Orleans - St. Paul - 23 Day Itinerary aboard American Melody
  • Explore Natchez's Grand Homes
  • Visit Oak Alley
  • Delve into Baton Rouge's history
  • Unravel Vicksburg's Civil War
Starts / Ends:
New Orleans / St. Paul
Activity Level:
Variable
Embark on a 23-day Mississippi River cruise, spanning 10 states on the American Melody. Explore the cultural tapestry of the Mighty Mississippi, touching on history, charm, and scenic landscapes. From lively New Orleans to Minneapolis, discover Baton Rouge's history, St. Francisville's …
Cruise Details
0
Explore beautiful Nashville
$4,840
Savings
EXPLORE

Music Cities Cruise

Memphis, TN to Nashville, TN - 9 Day Itinerary aboard American Symphony
  • Explore Memphis
  • Discover Paducah
  • Experience Lake Barkley
  • Enjoy Nashville
Starts / Ends:
Memphis / Nashville
Activities:
Small Ship Cruises
Activity Level:
Variable
Embark on a 9-day cruise from Memphis to Nashville aboard the American Symphony. Traverse the mighty Mississippi, majestic Ohio, and scenic Cumberland rivers. Experience the charm of historic towns, immerse yourself in local music culture, and enjoy nightly entertainment onboard. Relax and take in …
Cruise Details
0
Visit historic Minneapolis
$15,640
Savings
EXPLORE

Complete Mississippi River

New Orleans, LA to St. Paul, M - 23 Day Itinerary aboard American Symphony
  • Explore Natchez's Grand Homes
  • Visit Oak Alley
  • Delve into Baton Rouge's history
  • Unravel Vicksburg's Civil War
Starts / Ends:
New Orleans / St. Paul
Activity Level:
Variable
Embark on a 23-day Mississippi River cruise, spanning 10 states on the American Symphony. Explore the cultural tapestry of the Mighty Mississippi, touching on history, charm, and scenic landscapes. From lively New Orleans to Minneapolis, discover Baton Rouge's history, St. Francisville's …
Cruise Details
0
Mississippi River, St. Paul Minnesota
$6,530
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Symphony
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Witness wildlife and nature
  • Admire local artwork in Red Wing
Starts / Ends:
St. Louis / Red Wing
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Variable
Embark on a cruise along the Upper Mississippi River, exploring St. Louis, Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's home, witness diverse landscapes, and enjoy expert-guided tours. Adapt to the river's character as you relax on lounges, decks, or …
Cruise Details
0
Explore beautiful Nashville
$4,840
Savings
EXPLORE

Music Cities Cruise

Memphis, TN to Nashville, TN - 9 Day Itinerary aboard American Melody
  • Explore Memphis
  • Discover Paducah
  • Experience Lake Barkley
  • Enjoy Nashville
Starts / Ends:
Memphis / Nashville
Activities:
Small Ship Cruises
Activity Level:
Variable
Embark on a 9-day cruise from Memphis to Nashville aboard the American Melody. Traverse the mighty Mississippi, majestic Ohio, and scenic Cumberland rivers. Experience the charm of historic towns, immerse yourself in local music culture, and enjoy nightly entertainment onboard. Relax and take in …
Cruise Details
0
Mississippi River, St. Paul Minnesota
$4,530
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Heritage
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Witness wildlife and nature
  • Admire local artwork in Red Wing
Starts / Ends:
St. Louis / Red Wing
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Variable
Embark on a cruise along the Upper Mississippi River, exploring St. Louis, Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's home, witness diverse landscapes, and enjoy expert-guided tours. Adapt to the river's character as you relax on lounges, decks, or …
Cruise Details
0
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