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Top Mississippi River Trips & Tours

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View the iconic arch when you visit St. Louis, gateway to the west
from $9,920
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Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody
  • Explore historic Marietta, Ohio
  • Explore Maysville’s Railroad
  • Visit Louisville’s Churchill Downs
  • Tour Paducah’s wall murals
Starts / Ends
Pittsburgh / St. Louis
Activity Level
Variable
Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.
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Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $5,635
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Upper Mississippi River

St. Paul, MN - St. Louis, MO - 9 Day Itinerary aboard American Serenade
  • Tour historic Summit Avenue
  • Explore Dubuque River Museum
  • Experience John Deere Pavilion
  • Visit Mark Twain’s boyhood home
Starts / Ends
St. Paul / St. Louis
Activities
Urban Exploration, Wine Tasting, Biking
Activity Level
Variable
Set sail for 9 days aboard American Serenade from St. Paul to St. Louis. Walk through historic Summit Avenue, admire La Crosse from Grandad’s Bluff, explore Dubuque’s River Museum, and discover Mark Twain’s legacy in Hannibal. Experience curated onboard programs, live music, and the beauty of the Upper Mississippi’s diverse wildlife.
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Enjoy the colorful architecture of New Orleans
from $5,275
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Lower Mississippi River Cruise

New Orleans - Memphis - 9 Day Itinerary aboard American Melody
  • Explore New Orleans lively culture
  • Discover Oak Alley with landscapes
  • Discover Baton Rouge
  • Visit Graceland Memphis
Starts / Ends
New Orleans / Memphis
Activities
Wildlife Viewing, Village Visits, Archaeological Site Visits, Cooking Classes
Activity Level
Variable
Embark on a 9-day cruise from New Orleans to Memphis aboard American Melody, exploring Southern culture and history with local guides. Enjoy enriching excursions, gourmet meals, daily cocktails, and captivating shows at historic sites like Vicksburg and Natchez.
Cruise Details
0
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New Orleans paddlewheel steamer in New Orleans, Lousiana
Mississippi River

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TrustScore 4.9 | 1010 reviews
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3 months ago
It is a pleasure to work with efficient and pleasant people who make booking easy.
Jody Jordan
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11 months ago
Tilly and Alvin are great. There is so much that goes into planning a cruise, esp if you're a novice and getting guidance was so helpful. Tilly was so responsive and helpful. They both were.
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1 year ago
This is a very professional organization. They got back to me immediately over a question I had around booking insurance and made the issue very easy to resolve.
Gordon Peters
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1 year ago
Betty was extremely helpful and friendly! I have never traveled by long boat and was nervous about the options and the experience. Betty listened carefully to my wants and needs and presented exactly what my sister and I hoped for! I couldn’t have asked a more pleasant experience - I am so excited about our trip!!
Jan Struck
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1 year ago
Angie was patient and very pleasant
Elizabeth Traxler

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