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Panama's turquoise waters

San Blas Islands

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Explore the stunning San Blas Islands on one of Adventure Life's 15 exclusive tours for 2026-2027. These pristine islands, located off the coast of Panama, offer a unique opportunity to experience a tropical paradise with crystal-clear waters and white sandy beaches. On these tours, you can enjoy activities such as snorkeling, kayaking, and wildlife viewing, immersing yourself in the beauty of the natural surroundings. Over 8 to 15 days, you'll have the chance to visit local villages, learn about the indigenous Guna culture, and relax on secluded beaches. With prices starting at $3,150 to $69,990, now is the perfect time to plan your escape to the San Blas Islands. To start your journey to this idyllic destination, contact one of Adventure Life's travel specialists for assistance in creating your dream tropical getaway.
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Ruins in Colon, Panama
from $13,300
EXPLORE

Costa Rica & Panama Coastal Expedition Cruise

Liberia Airport to Panama City - 15 Day Itinerary aboard Safari Voyager
  • Explore Santa Rosa Wilderness
  • Visit Embera Cultural Village
  • Cross Panama Canal
  • Discover Guna Yala Islands
Starts / Ends
Liberia / Panama City
Activities
Snorkeling, Wildlife Viewing, Village Visits, Hiking, Archaeological Site Visits, Kayaking, Rainforest Exploration, Whale Watching
Activity Level
Variable
Experience a 15-day expedition cruise from Liberia, Costa Rica, to Panama City, Panama, aboard Safari Voyager. Explore remote national parks, tropical islands, vibrant reefs, and Indigenous communities while kayaking, snorkeling, hiking, and crossing the iconic Panama Canal on an unforgettable small-ship adventure.
Cruise Details
0
Ocean view of the edge of Manuel Antonio National Park, Costa Rica
from $6,450
EXPLORE

The Natural Wonders of Central America – with Smithsonian Journeys

Colon to Puntarenas - 8 Day Itinerary aboard Le Bougainville
  • Visit San Blas Islands
  • Cross Panama Canal locks
  • Discover Balboa waterfront district
  • Reach Puntarenas Pacific coast
Starts / Ends
Colon / Puntarenas
Activities
Local Market Visits
Activity Level
Variable
Explore Panama and Costa Rica on an 8-day voyage aboard Le Bougainville. Visit Colon, Portobelo, the San Blas Islands, Balboa, Quepos, and Puntarenas. Cross the Panama Canal, discover Afro-Caribbean heritage, meet Indigenous communities, relax at sea, and experience rainforest-lined Pacific shores.
Cruise Details
0
Clear waters of the Caribbean sea
from $7,170
EXPLORE

Panama and Costa Rica by Sea - with Smithsonian Journeys

Puntarenas to Colon - 8 Day Itinerary aboard Le Laperouse
  • Explore Darien National Park
  • Embera village visit
  • See Miraflores Locks view
  • Experience Guna community encounter
Starts / Ends
Puntarenas / Colon
Activity Level
Variable
Set sail on an 8-day cruise from Puntarenas to Colon aboard Le Laperouse. Explore Quepos, Darien National Park, Flamenco Island, the San Blas Islands, and complete the full Panama Canal crossing with cultural encounters and wildlife viewing.
Cruise Details
0
Keel-billed Toucan
from $6,230
EXPLORE

Central America Jewels & Panama Canal

Colon to Puntarenas - 8 Day Itinerary aboard Le Laperouse
  • Explore San Blas Islands
  • Discover Historic Portobelo
  • Transit Panama Canal
  • Encounter Costa Rica Wildlife
Starts / Ends
Colon / Puntarenas
Activities
Spa Relaxation
Activity Level
Variable
Explore Panama and Costa Rica on this 8-day voyage from Colón to Puntarenas aboard Le Laperouse. Travel through the Panama Canal, visit the San Blas Islands, Portobelo and Darién National Park, and discover local communities, coastal landscapes and wildlife. The journey also includes time at sea and excursions in Costa Rica’s Osa Peninsula region.
Cruise Details
0
Boats Moored to the Quay at Bridgetown Harbour
from $4,450
EXPLORE

Barbados to Panama

15 Day Itinerary aboard Royal Clipper
  • Explore Bridgetown, Barbados
  • Enjoy Grenada's unique aromas
  • Discover Dutch colonial Curacao
  • Transit the historic Panama Canal
Starts / Ends
Bridgetown / Balboa
Activity Level
Variable
Starting at the Caribbean port of Bridgetown, this 15-day cruise aboard the Royal Clipper sails through the turquoise Caribbean waters en route to the Panama Canal, visiting Grenada, Bonaire, Curacao, Aruba, and Colombia along the way. Explore the tropical jungles, snorkel in vibrant reefs, immerse yourself in tribal culture, and marvel at the Panama Canal.
Cruise Details
0
San Blas
from $7,790
EXPLORE

Secrets of Central America

Colon - Puntarenas - 11 Day Itinerary aboard Le Bellot
  • Learn Fort San Lorenzo's history
  • See San Blas Islands' marine life
  • Experience Coiba Island adventure
  • Witness Drake Bay rainforest
Starts / Ends
Colon / Puntarenas
Activity Level
Variable
Explore Panama and Costa Rica aboard Le Bellot on an 11-day cruise. Sail through the Panama Canal, visit Fort San Lorenzo, the San Blas Islands, Pearl Islands, Darién National Park, Coiba Island, Rio Esquinas, Drake Bay, and Curú Wildlife Refuge. Experience wildlife viewing, Zodiac landings, and cultural encounters with indigenous communities.
Cruise Details
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Balboa
from $3,150
EXPLORE

Panama to Aruba

12 Day Itinerary aboard Star Clipper
  • Transit the Panama Canal locks
  • Walk colonial Balboa streets
  • Explore forts in Portobelo
  • Visit San Blas and Guna villages
  • See Cartagena and Santa Marta
Starts / Ends
Balboa / Oranjestad
Activities
Small Ship Sailing
Activity Level
Variable
Sail the Panama Canal on a 10-day Star Clippers cruise through Central America. Begin in Balboa, then transit the Panama Canal and see the locks in action. Explore Spanish forts in Portobelo, meet the Guna people in the San Blas Islands, and discover Colombia’s coastal cities of Cartagena and Santa Marta. Enjoy scenic days under sail.
Cruise Details
0
Paradise Tropical Island - Bocas del Toro archipelago - Island Colon
from $24,990
EXPLORE

Pristine Islands of the Bahamas & the Panama Canal

Nassau - Panama City - 11 Day Itinerary aboard Scenic Eclipse
  • Explore Nassau’s colonial streets
  • Visit Staniel Cay’s beaches
  • Discover San Salvador’s coral reefs
  • Meet Cabo de La Vela’s Wayuu people
Starts / Ends
Nassau / Panama City
Activity Level
Variable
Join an 11-day cruise from Nassau to Panama City on the Scenic Eclipse, exploring the Bahamas' clear waters and vibrant island cultures. Experience highlights like Pig Beach and the Panama Canal, blending leisure with cultural discovery.
Cruise Details
0
Snorkeling
from $7,910
No SS
EXPLORE

Panama, Colombia & Caribbean Islands

Colon - Fort-de-France - 11 Day Itinerary aboard Le Bellot
  • Cartagena colonial old town
  • Visit Santa Marta and Sierra Nevada
  • Visit Bonaire reef marine park
  • Visit Fort-de-France landmarks
Starts / Ends
Colon / Fort de France
Activities
Scuba Diving
Activity Level
Variable
Set sail on an 11-day cruise through Panaman, Colombia and Caribbean Islands aboard Le Bellot. Visit Cartagena and Santa Marta with guided historic and cultural excursions. Explore the San Blas Islands for beaches, snorkeling, and Kuna culture. The voyage combines nature, culture, and Caribbean island experiences.
Cruise Details
0
Sunset over Cartagena, Colombia
from $6,450
HALF DEP
EXPLORE

Panama and Colombia: Exploring the Caribbean Coast

Panama to Cartagena - 8 Day Itinerary aboard National Geographic Quest
  • Transit the Panama Canal
  • Meet Indigenous people of Guna Yala
  • Look for unique tropical wildlife
  • See colonial architecture
Starts / Ends
Panama City / Cartagena
Activities
Stand Up Paddle Boarding
Activity Level
Variable
Discover an astonishing trove of natural and cultural treasures as you navigate the Caribbean coasts of Panama and Colombia on this 8-day cruise aboard the National Geographic Quest. Sail from Panama City to Cartagena, with stops in Portobelo, Guna Yala, Archipelago, and more.
Cruise Details
0
Relax on the shores of the Caribbean
from $12,295
EXPLORE

Grenadines, Colombia & Panama Canal Transit

Bridgetown - Panama City - 12 Day Itinerary aboard Emerald Azzurra
  • Explore Bequia Caribbean lifestyle
  • Admire Cartagena Old Town
  • See San Blas Islands nature
  • Navigate the Panama Canal
Starts / Ends
Bridgetown / Panama City
Activity Level
Variable
Set sail on a 12-day Caribbean cruise from Bridgetown aboard the Emerald Azzurra, exploring islands like Bequia and Mayreau. Conclude your journey in Panama City after traversing the historic Panama Canal and enjoying vibrant local cultures and stunning coastal views.
Cruise Details
0
Sunset over Cartagena, Colombia
from $12,295
EXPLORE

Panama Canal Transit, Colombia & the Grenadines

Panama City - Bridgetown - 12 Day Itinerary aboard Emerald Azzurra
  • Explore Cartagena walled Old Town
  • Discover Santa Marta oldest city
  • Tour Willemstad Queen Emma Bridge
  • See Mayreau Island Station Hill
Starts / Ends
Panama City / Bridgetown
Activities
Urban Exploration
Activity Level
Variable
Set sail on a 12-day Caribbean cruise from Bridgetown aboard the Emerald Azzurra, exploring islands like Bequia and Mayreau. Conclude your journey in Panama City after traversing the historic Panama Canal and enjoying vibrant local cultures and stunning coastal views.
Cruise Details
0
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Franny F.
Panama's turquoise waters
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