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Sloth in the rainforest canopy

Panama Wildlife & Safari Trips

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Select one of these 3 wildlife experiences to Panama in 2025 or 2026. Custom plan your Panama nature adventure with our expert trip planners, including visits to Colon, Panama Canal, Isla Coiba, Panama City, and Barro Colorado. Wildlife and safari trips to Panama start at $6,320 for a 8 to 13 days adventure in nature. Contact one of our Panama wildlife and nature travel experts for help planning your next trip.
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Panama Canal
from $6,320
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Costa Rica and the Panama Canal

Eastbound - 8 Day Itinerary aboard National Geographic Quest
  • Observe animals in their habitat
  • Kayak through magical mangroves
  • Transit the historical Panama Canal
  • Explore Gulf of Panama beaches
Activities
Land & Sea Exploration, Snorkeling, Kayaking, Horseback Riding, Stand Up Paddle Boarding
Activity Level
Variable
Discover Costa Rica & Panama on this wonderful 8-day expedition cruise aboard the National Geographic Quest. Venture into remote wilderness and hike among monkeys, sloths, and tropical birds, explore idyllic islands, snorkel over a vibrant coral reef, and take an expedition landing craft cruise through mangroves.
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Panama Canal
from $12,795
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Costa Rica and The Panama Canal

San Jose - Panama - 12 Day Itinerary aboard Sylvia Earle
  • Cross Panama Canal
  • Explore biodiverse rainforests
  • Visit Coiba National Park
  • Enjoy Manuel Antonio National Park
Starts / Ends
San Jose / Panama City
Activities
Village Visits
Activity Level
Variable
Embark on a 12-day cruise aboard the Sylvia Earle to explore Central America's rich ecosystems, from Costa Rica's diverse wildlife to Panama's vibrant coral reefs. Experience a memorable daylight transit through the historic Panama Canal, witnessing this engineering marvel firsthand.
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Look for unique birds and other wildlife in the rain forest!
from $12,955
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Natural Wonders, Engineering Marvels

Puntarenas - Colon - 13 Day Itinerary aboard Sea Cloud Spirit
  • Explore Nicoya Peninsula beaches
  • Visit Pearl Islands Discover Pea
  • Discover Marina Flamingo
  • Relax at Playa Panama
  • Sail through the Panama Canal
Starts / Ends
Puntarenas / Colon
Activities
Hiking, Wildlife Viewing, Rainforest Exploration, Small Ship Sailing, Fishing
Activity Level
Variable
Experience the essence of “Pura Vida” on a 13-day Panama cruise from Puntarenas to Colon. Visit Punta Leona, Marina Flamingo, Playa Panama, Quepos, Puerto Jimenez, the Pearl Islands, and the San Blas Archipelago, exploring rainforests, beaches, & marinas while encountering diverse wildlife and witnessing the engineering marvel of the Panama Canal.
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