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Panama Wildlife & Safari Trips

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Select one of these 5 wildlife experiences to Panama in 2026 or 2027. Custom plan your Panama nature adventure with our expert trip planners, including visits to Colon, Panama Canal, San Blas Islands, Isla Coiba, and Panama City. Wildlife and safari trips to Panama start at $6,801 for a 8 to 13 days adventure in nature. Contact one of our Panama wildlife and nature travel experts for help planning your next trip.
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San Blas
from $7,790
EXPLORE

Secrets of Central America

Colon - Puntarenas - 11 Day Itinerary aboard Le Bellot
  • Learn Fort San Lorenzo's history
  • See San Blas Islands' marine life
  • Experience Coiba Island adventure
  • Witness Drake Bay rainforest
Starts / Ends
Colon / Puntarenas
Activity Level
Variable
Explore Panama and Costa Rica aboard Bellot on an 11-day cruise. Sail through the Panama Canal, visit Fort San Lorenzo, the San Blas Islands, Pearl Islands, Darién National Park, Coiba Island, Rio Esquinas, Drake Bay, and Curú Wildlife Refuge. Experience wildlife viewing, Zodiac landings, and cultural encounters with indigenous communities.
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Clear waters of the Caribbean sea
from $7,170
EXPLORE

Panama and Costa Rica by Sea - with Smithsonian Journeys

Puntarenas to Colon - 8 Day Itinerary aboard Le Laperouse
  • Explore Darien National Park
  • Embera village visit
  • See Miraflores Locks view
  • Experience Guna community encounter
Starts / Ends
Puntarenas / Colon
Activities
Village Visits
Activity Level
Variable
Set sail on an 8-day cruise from Puntarenas to Colon aboard Le Laperouse. Explore Quepos, Darien National Park, Flamenco Island, the San Blas Islands, and complete the full Panama Canal crossing with cultural encounters and wildlife viewing.
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Explore beautiful Costa Rica
from $6,801
HALF DEP
EXPLORE

Exploring Arenal Volcano, Pearl Islands and the Panama Canal

San Jose to Panama - 9 Day Itinerary aboard National Geographic Quest
  • Arenal Volcano exploration
  • Relax in Ecotermales hot springs
  • Pearl Islands snorkeling
  • Navigate the Panama Canal
Starts / Ends
San Jose / Panama City
Activities
Wildlife Viewing, Rainforest Exploration, Archaeological Site Visits, Hiking, Land & Sea Exploration, Snorkeling, Stand Up Paddle Boarding, Kayaking
Activity Level
Variable
Arrive in San Jose, transfer to La Fortuna and start the 9-day land and sea adventure. Explore Arenal Volcano and rainforest trails. Fly to Panama City and embark National Geographic Quest. Kayak, hike, and cruise the Panama Canal, Gatun Lake, and Pearl Islands while snorkeling, exploring fortresses, and discovering tropical wildlife.
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Panama Canal
from $14,495
EBD
EXPLORE

Costa Rica and The Panama Canal

San Jose - Panama - 12 Day Itinerary aboard Sylvia Earle
  • Cross Panama Canal
  • Explore biodiverse rainforests
  • Visit Coiba National Park
  • Enjoy Manuel Antonio National Park
Starts / Ends
San Jose / Panama City
Activity Level
Variable
Embark on a 12-day cruise aboard the Sylvia Earle to explore Central America's rich ecosystems, from Costa Rica's diverse wildlife to Panama's vibrant coral reefs. Experience a memorable daylight transit through the historic Panama Canal, witnessing this engineering marvel firsthand.
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Look for unique birds and other wildlife in the rain forest!
from $12,965
EBD 30%
EXPLORE

Natural Wonders, Engineering Marvels

Puntarenas - Colon - 13 Day Itinerary aboard Sea Cloud Spirit
  • Explore Nicoya Peninsula beaches
  • Visit Pearl Islands Discover Pea
  • Discover Marina Flamingo
  • Relax at Playa Panama
  • Sail through the Panama Canal
Starts / Ends
Puntarenas / Colon
Activities
Small Ship Sailing, Fishing
Activity Level
Variable
Experience the essence of “Pura Vida” on a 13-day Panama cruise from Puntarenas to Colon. Visit Punta Leona, Marina Flamingo, Playa Panama, Quepos, Puerto Jimenez, the Pearl Islands, and the San Blas Archipelago, exploring rainforests, beaches, & marinas while encountering diverse wildlife and witnessing the engineering marvel of the Panama Canal.
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