Arrive in St. Louis and check in to your deluxe hotel, which is adjacent to the city’s attractions. Wonder at the St. Louis Arch, an unequaled architectural statement that defines this storied town, then continue your architectural tour at the imposing Cathedral of St. Louis. Indulge a less lofty American pastime at the Anheuser-Busch brewery, an American classic.

Your fare includes breakfast this morning at your hotel as well as a transfer to the Louisiane and all porterage. Settle into your stateroom or suite, head to The Veranda for a light snack, and then bid St. Louis farewell as the Louisiane departs and you immerse yourself in the joys of life on the river. Bon voyage!

Get tickled by the Popeye Museum and the beloved sailor's statue, found here in the hometown of his creator, E. C. Segar. Journey to Ste. Genevieve and admire the preserved French Colonial architecture.

Engage with history at this battle site where Union and Confederate soldiers clashed in a fierce barrage of artillery. Study the illuminating murals peppering the town, and visit the lovingly restored Glenn House, a reminder of a more genteel time.

Picture 42,000 Union soldiers boarding 185 ships on their way upriver, and you can get a sense of the rich local history that is captured at the Floodwall Murals. See the Wacinton Sculpture honoring the Chickasaw Indians and tour the enchanting National Quilt Museum.

Seek inspiration in Henderson, as did both the unequalled naturalist John James Audubon and blues legend W. C. Handy. Visit the John James Audubon Museum, which displays the world's largest collection of Audubon art and artifacts.

Discover captivating Louisville, named after King Louis XVI of France, as you sip a mint julep and stroll the waterfront. Be sure to head to the Louisville Slugger Museum and Factory, Churchill Downs, or learn about a boxing legend at the Muhammad Ali Center.

Bid adieu to the Louisiane and begin your journey home.