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Madison, Indiana River Cruises

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Experience the charm and beauty of Madison on a river cruise with Adventure Life in 2025. With 1 unique river cruises available ranging from 16 days in length, you'll have the opportunity to sail through the heart of Indiana, immersing yourself in the local culture and history. Navigating the river, you'll discover quaint villages, historic landmarks, and stunning natural landscapes along the way. Explore the rich cultural heritage of Madison, indulge in delicious local cuisine, and witness the diverse wildlife that calls the area home. Whether you're interested in historical sites, wildlife viewing, or simply relaxing on deck and taking in the picturesque surroundings, a river cruise in Madison offers something for everyone. Don't miss the chance to join us on an unforgettable journey through this charming destination. Contact one of our award-winning river cruise experts for help planning your next seamless trip.
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View the iconic arch when you visit St. Louis, gateway to the west
from $9,240
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Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody
  • Explore historic Marietta, Ohio
  • Explore Maysville’s Railroad
  • Visit Louisville’s Churchill Downs
  • Tour Paducah’s wall murals
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Pittsburgh / St. Louis
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Wildlife Viewing, Village Visits, Urban Exploration, Archaeological Site Visits
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Variable
Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.
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