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Ohio River Urban Exploration Cruises

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Discover the vibrant urban landscapes of the Ohio River on our 2 urban exploration tours for 2025. Join us on a journey that seamlessly blends history, culture, and architecture, providing an in-depth understanding of this remarkable destination. Over 9 days, you will explore the heart of the American Midwest, starting from cities like Louisville and Nashville, known for their music and small-town charm. Taste famous Kentucky bourbon, enjoy live music, and admire historic handicrafts along the way. Experience the laid-back hospitality of the region as you cruise through picturesque villages and vibrant cities like St. Louis. To embark on a journey that unveils the magic of the Ohio River's diverse landscapes and urban environments, contact one of Adventure Life's tour specialists for help planning your next seamless trip.
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    • Ohio River
Explore Pittsburgh
from $5,275
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Ohio River Cruise

Pittsburgh - Louisville - 9 Day Itinerary aboard American Melody
  • Explore Pittsburgh’s rich history
  • Visit historic Marietta, OH
  • Tour Cincinnati’s top sites
  • Experience Louisville Derby legacy
Starts / Ends
Pittsburgh / Louisville
Activities
Small Ship Sailing, Wine Tasting, Village Visits
Activity Level
Variable
Embark on a 9-day cruise along the Ohio River aboard the American Melody from Pittsburgh to Louisville. Discover historic towns and cultural landmarks while enjoying guided tours, historic excursions, and breathtaking river views as you cruise through America’s heartland.
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Explore beautiful Nashville
from $4,915
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Tennessee Rivers Cruise

Nashville to Chattanooga - 9 Day Itinerary aboard American Symphony
  • Explore Nashville’s music landmarks
  • Visit Paducah’s Quilt Museum
  • Walk historic Shiloh battlefield
  • Cruise through Appalachian scenery
Starts / Ends
Nashville / Chattanooga
Activities
Urban Exploration, Local Market Visits, Archaeological Site Visits
Activity Level
Variable
Set sail on a 9-day Tennessee Rivers Cruise from Nashville to Chattanooga aboard American Symphony. Relax with expert talks, regional cuisine, and comfortable accommodation while exploring the history, culture, and natural beauty of America’s heartland.
Cruise Details
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