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Hannibal, Missouri River Cruises

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Discover the magic of 2025 with a river cruise in Hannibal, Missouri. Join us on a trip to this charming destination, known for its rich history as the hometown of Mark Twain. Navigate the mighty Mississippi River and immerse yourself in the cultural heritage of this iconic region. Discover the beauty of the surrounding landscapes and indulge in the local cuisine and wines. From wildlife viewing to historical sites, there is something for everyone on these river cruises. Don't miss out on this unforgettable experience - contact one of our river cruise experts for help planning your next seamless trip.
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    • Hannibal
View the iconic arch when you visit St. Louis, gateway to the west
from $12,999
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America’s Great River

St. Paul to New Orleans - 15 Day Itinerary aboard Viking Mississippi
  • Explore St. Louis' arts scene
  • Enjoy American music styles
  • Learn Civil War history
  • Experience New Orleans' culture
  • Visit the Quad Cities
Starts / Ends
St. Paul / New Orleans
Activity Level
Variable
Cruise America's great river on this 15-day itinerary aboard Viking Mississippi. Journey from St. Paul, Minnesota to New Orleans, Louisiana and explore highlights of the mighty Mississippi River. Along the way, visit historic ports such as St. Louis, Memphis, Baton Rouge, and more.
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Mississippi River, St. Paul Minnesota
from $5,635
Savings
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Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Melody
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Witness wildlife and nature
  • Admire local artwork in Red Wing
Starts / Ends
St. Louis / Red Wing
Activity Level
Variable
Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Melody. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
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0
Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $12,620
Savings
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Grand Heartland Cruise

Minnesota - Louisiana - 16 Day Itinerary aboard American Serenade
  • Visit mansions and art galleries
  • See the Gateway Arch and St. Louis
  • Visit Natchez’s antebellum homes
  • Experience Memphis' musical legacy
Starts / Ends
St. Paul / New Orleans
Activities
Village Visits, Archaeological Site Visits, Urban Exploration, Wine Tasting, Local Market Visits, Wildlife Viewing, Biking
Activity Level
Variable
Embark on a 16-day Mississippi River cruise from Minnesota to Louisiana aboard American Serenade, exploring St. Paul to New Orleans with stops in La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, and Natchez. Enjoy onboard activities, stunning scenery, and experiences like the Mark Twain Boyhood Home and more.
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Mississippi River, St. Paul Minnesota
from $4,610
Savings
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Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Heritage
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Witness wildlife and nature
  • Admire local artwork in Red Wing
Starts / Ends
St. Louis / St. Paul
Activity Level
Variable
Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Heritage. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
Cruise Details
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Visit historic Minneapolis
from $15,890
Savings
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Complete Mississippi River

New Orleans - St. Paul - 23 Day Itinerary aboard American Melody
  • Explore Natchez's Grand Homes
  • Visit Oak Alley
  • Delve into Baton Rouge's history
  • Unravel Vicksburg's Civil War
Starts / Ends
New Orleans / St. Paul
Activity Level
Variable
Discover the Mighty Mississippi on a 23-day cruise covering 10 states aboard American Melody. Immerse in history, culture, and cuisine from New Orleans to Minneapolis, exploring charming ports along the way.
Cruise Details
0
Mississippi River, St. Paul Minnesota
from $5,635
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Symphony
  • Explore Mark Twain’s hometown
  • Cruise through historic towns
  • Explore St. Paul's grand mansions
  • Visit National River Museum
Starts / Ends
St. Louis / Red Wing
Activities
Cooking Classes
Activity Level
Variable
Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Symphony. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
Cruise Details
0
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