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La Crosse

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Explore Mississippi River with a trip to La Crosse. Find your ideal La Crosse vacation for 2025-2026. Choose from trips that range from 15 to 16 days. Spend you time on excursions including Archaeological Site Visits, Village Visits, Biking, Local Market Visits, and Urban Exploration. Our La Crosse packages range in price from $12,620 to $30,999. Contact us and our team will help you start planning to make it a reality.
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    • La Crosse
Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $12,620
Savings
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Grand Heartland Cruise

Minnesota - Louisiana - 16 Day Itinerary aboard American Serenade
Starts / Ends
St. Paul / New Orleans
Activities
Village Visits, Archaeological Site Visits, Wine Tasting, Urban Exploration, Wildlife Viewing, Local Market Visits, Biking
Activity Level
Variable
Embark on a 16-day Mississippi River cruise from Minnesota to Louisiana aboard American Serenade, exploring St. Paul to New Orleans with stops in La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, and Natchez. Enjoy onboard activities, stunning scenery, and experiences like the Mark Twain Boyhood Home and more.
  • Visit mansions and art galleries
  • See the Gateway Arch and St. Louis
  • Visit Natchez’s antebellum homes
  • Experience Memphis' musical legacy
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View the iconic arch when you visit St. Louis, gateway to the west
from $12,999
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America’s Great River

St. Paul to New Orleans - 15 Day Itinerary aboard Viking Mississippi
Starts / Ends
St. Paul / New Orleans
Activity Level
Variable
Cruise America's great river on this 15-day itinerary aboard Viking Mississippi. Journey from St. Paul, Minnesota to New Orleans, Louisiana and explore highlights of the mighty Mississippi River. Along the way, visit historic ports such as St. Louis, Memphis, Baton Rouge, and more.
  • Explore St. Louis' arts scene
  • Enjoy American music styles
  • Learn Civil War history
  • Experience New Orleans' culture
  • Visit the Quad Cities
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