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La Crosse, Wisconsin River Cruises

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Experience the natural beauty and charm of La Crosse on one of Adventure Life's 2 invigorating river cruises in 2025. Nestled along the Mississippi River, La Crosse offers a unique blend of outdoor adventures and cultural experiences. Sail through picturesque landscapes, explore quaint villages, and indulge in delicious local cuisine. Discover the region's rich history, vibrant wildlife, and stunning scenery during your 15 to 16 days river cruise. Whether you're interested in wildlife viewing, hiking, or simply relaxing on deck, La Crosse has something for everyone. Join us on a trip to La Crosse and contact one of our award-winning river cruise experts for help planning your next seamless adventure.
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    • La Crosse
Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
from $12,620
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Grand Heartland Cruise

Minnesota - Louisiana - 16 Day Itinerary aboard American Serenade
Starts / Ends
St. Paul / New Orleans
Activities
Village Visits, Archaeological Site Visits, Wine Tasting, Urban Exploration, Wildlife Viewing, Local Market Visits, Biking
Activity Level
Variable
Embark on a 16-day Mississippi River cruise from Minnesota to Louisiana aboard American Serenade, exploring St. Paul to New Orleans with stops in La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, and Natchez. Enjoy onboard activities, stunning scenery, and experiences like the Mark Twain Boyhood Home and more.
  • Visit mansions and art galleries
  • See the Gateway Arch and St. Louis
  • Visit Natchez’s antebellum homes
  • Experience Memphis' musical legacy
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View the iconic arch when you visit St. Louis, gateway to the west
from $12,999
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America’s Great River

St. Paul to New Orleans - 15 Day Itinerary aboard Viking Mississippi
Starts / Ends
St. Paul / New Orleans
Activity Level
Variable
Cruise America's great river on this 15-day itinerary aboard Viking Mississippi. Journey from St. Paul, Minnesota to New Orleans, Louisiana and explore highlights of the mighty Mississippi River. Along the way, visit historic ports such as St. Louis, Memphis, Baton Rouge, and more.
  • Explore St. Louis' arts scene
  • Enjoy American music styles
  • Learn Civil War history
  • Experience New Orleans' culture
  • Visit the Quad Cities
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