Have questions? We're here.
Mississippi River, St. Paul Minnesota

Best Mississippi River Trips & Vacation Packages

Travel made your way ™
Talk with an expert
Build your ideal Mississippi River trip. Call 800.344.6118
Start Planning My Trip
Talk with an expert
Filter (27 Results)
  • Start Date
    Months
    Years
  • Length
    to
  • Price
    to
  • Activity Levels
  • Experiences
  • Activities
  • Ships
  • Destinations
    • Mississippi River
View the iconic arch when you visit St. Louis, gateway to the west
from $9,920
Savings
EXPLORE

Grand Ohio River Cruise

Pittsburgh to St. Louis - 16 Day Itinerary aboard American Melody
  • Explore historic Marietta, Ohio
  • Explore Maysville’s Railroad
  • Visit Louisville’s Churchill Downs
  • Tour Paducah’s wall murals
Starts / Ends
Pittsburgh / St. Louis
Activity Level
Variable
Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.
Cruise Details
0
Visit historic and hilly Pittsburgh
from $9,920
Savings
EXPLORE

Grand Ohio River Cruise

St. Louis to Pittsburgh - 16 Day Itinerary aboard American Melody
  • Explore St. Louis history
  • Discover Paducah river heritage
  • Explore Louisville traditions
  • Discover Cincinnati heritage
Starts / Ends
St. Louis / Pittsburgh
Activities
Archaeological Site Visits, Urban Exploration, Village Visits, Wildlife Viewing
Activity Level
Variable
Explore a 16-day Mississippi and Ohio River cruise from St. Louis to Pittsburgh aboard American Melody. Visit Paducah, Henderson, Evansville, Louisville, Madison, Cincinnati, Maysville, and Marietta, with time for museums, historic districts, Underground Railroad sites, regional art, river heritage, and American history. Discover local history.
Cruise Details
0
Mississippi River, St. Paul Minnesota
from $5,635
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Symphony
  • Explore Mark Twain’s hometown
  • Cruise through historic towns
  • Explore St. Paul's grand mansions
  • Visit National River Museum
Starts / Ends
St. Louis / Red Wing
Activities
Cooking Classes, Wine Tasting
Activity Level
Variable
Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Symphony. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
Cruise Details
0
25-27 of 27 Results

Plan smarter. Spend better.

Talk with an expert trip planner 800.344.6118

Plan My Trip
Erin Correia
Erin C.
New Orleans paddlewheel steamer in New Orleans, Lousiana
Mississippi River

Chat Mississippi River with a specialist

Our team is waiting and ready to talk with you about your next adventure. So go ahead and book an appointment with one of our specialized trip planners.

Let's Chat
800.344.6118

Where is your next adventure?

Contact Chat Call
TrustScore 4.9 | 1047 reviews
TrustScore 4.9 of 5
total score
Based on 1047 reviews on
review score
5 months ago
It is a pleasure to work with efficient and pleasant people who make booking easy.
Jody Jordan
review score
1 year ago
Tilly and Alvin are great. There is so much that goes into planning a cruise, esp if you're a novice and getting guidance was so helpful. Tilly was so responsive and helpful. They both were.
Robin
review score
1 year ago
This is a very professional organization. They got back to me immediately over a question I had around booking insurance and made the issue very easy to resolve.
Gordon Peters
review score
1 year ago
Betty was extremely helpful and friendly! I have never traveled by long boat and was nervous about the options and the experience. Betty listened carefully to my wants and needs and presented exactly what my sister and I hoped for! I couldn’t have asked a more pleasant experience - I am so excited about our trip!!
Jan Struck
review score
1 year ago
Angie was patient and very pleasant
Elizabeth Traxler

Why Travel With Us?

Seamless Trip Planning

We guide you through every detail beyond the cruise—from flights to pre- and post-trip stays—so your journey feels effortless.

Advocacy That Matters

You're backed by a team that knows the industry and has strong relationships—helping ensure you're prioritized and well taken care of every step of the way.

Rewards That Go Further

Secure your 5% Past Traveler Rewards across a wide range of ships and destinations - not a single brand and not just cruises.

As Featured In

USA Today
Los Angeles Times
Travel Weekly
Outside
National Geographic Traveler
The New York Times
Travel + Leisure
Condé Nast Traveler
National Geographic

How it Works

Connect

No cost, no commitment. Talk with our experts about your dream trip.

Plan

Share your travel style—we match you with the right itinerary or create one just for you.

Book

Lock in knowing every detail is handled and you’re fully supported.

Travel

Enjoy a seamless journey—and unlock 5% off your next adventure.

Erin Correia
Erin C
Plan My Trip
We love travel, talk with an expert 800.344.6118