Top Mississippi River Tours & Cruises in 2027

Discover the Mighty Mississippi on a 23-day cruise covering 10 states aboard American Melody. Immerse in history, culture, and cuisine from New Orleans to Minneapolis, exploring charming ports along the way.

Experience a 9-day cruise aboard American Melody from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

Set sail on a 12-day Mississippi river cruise aboard the American Symphony, from New Orleans to Memphis, visiting Southern landmarks like Oak Alley, Houmas House, and Vicksburg National Military Park. Explore Baton Rouge's history, Natchez's antebellum homes, and Cleveland's musical heritage.

Take an 8-day Viking Mississippi cruise through Memphis, Cape Girardeau, Paducah, Clarksville, and Nashville. Visit key cultural and historical sites, from music landmarks to Civil War history and regional museums.

Embark on a 9-day cruise from New Orleans to Memphis aboard American Melody, exploring Southern culture and history with local guides. Enjoy enriching excursions, gourmet meals, daily cocktails, and captivating shows at historic sites like Vicksburg and Natchez.

The American Melody hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.

Embark on a 12-day Mississippi River cruise from New Orleans to Louisville aboard American Heritage. Explore iconic sites like Oak Alley, Vicksburg, and Memphis. Enjoy enriching excursions, Civil War history, live music, and Southern cuisine.

Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.

Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Symphony. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.