Top Mississippi River Tours & Cruises in 2027

Take an 8-day Viking Mississippi cruise through Memphis, Cape Girardeau, Paducah, Clarksville, and Nashville. Visit key cultural and historical sites, from music landmarks to Civil War history and regional museums.

Experience a 9-day cruise aboard American Symphony from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

Experience a 9-day cruise aboard American Splendor from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

Cruise on a 9-day voyage aboard American Melody along the Mississippi River. Visit Cleveland, Vicksburg, Natchez, Baton Rouge, and Oak Alley through included excursions featuring museums, Civil War sites, historic homes, and music heritage. This itinerary combines Mississippi River scenery with Southern history and culture.

The American Melody hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.

Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.

Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Symphony. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.