Top Mississippi River Tours & Cruises in 2027

The American Melody hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.

Embark on a 12-day Mississippi River cruise from New Orleans to Louisville aboard American Heritage. Explore iconic sites like Oak Alley, Vicksburg, and Memphis. Enjoy enriching excursions, Civil War history, live music, and Southern cuisine.

Explore the Upper Mississippi River aboard the American Heritage on this 9-day cruise from St. Louis to Minneapolis. Begin in St. Louis, Missouri, and travel through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns and take in the diverse scenery.

Sail from Pittsburgh to St. Louis on a 16-day Ohio River cruise aboard American Melody. Visit historic towns like Marietta, Cincinnati, Louisville, and Paducah. Discover museums, landmark sites, and cultural excursions while enjoying daily enrichment programs and scenic cruising.

Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Symphony. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.